Results 61 to 70 of about 17,815 (220)

Metabolic Reprogramming and GM‐CSF Secretion in Areca Nut‐Activated Fibroblasts Drive Oral Precancer Progression

Oral Diseases, EarlyView.
ABSTRACT Objective Oral cancer, with a rising global incidence and poor prognosis, is associated with areca nut use in South and Southeast Asia. In this study, we addressed the effects of areca nut extract (ANE) on oral carcinogenesis by modulating fibroblast behavior in oral tissue.
Yen‐Yun Wang, Chang‐Wei Su, Chih‐Huang Tseng, Pang‐Yu Chen, Hieu D. H. Nguyen, Leong‐Perng Chan, Yuk‐Kwan Chen, Shih Sheng Jiang, Steven Lo, Shyng‐Shiou F. Yuan   +9 more
wiley   +1 more source

Review on the current status of Syrian hamsters as an animal model for COVID-19 transmission, pathogenesis, treatment and vaccine research

All Life
Animal models have historically played a crucial role in understanding emerging infectious diseases and developing preventive measures such as vaccines and therapeutics.
Biruh Mebratu Belay, Abebe Tesfaye Gessese, Mebrie Zemene Kinde, Gashaw Getaneh Dagnaw   +3 more
doaj   +1 more source

Assessment of the Pathogenicity of Candidatus Rickettsia Colombiensis in a Syrian Hamster Model and Serological Cross-Reactivity Between Spotted Fever Rickettsia Species

Pathogens
Candidatus Rickettsia colombiensis is a new candidate species of Rickettsiae spotted fever group that have been isolated only from ticks. The pathogenicity of Ca. R. colombiensis to human and animals is unknown.
Jorge Miranda, Alejandra García, Cristina Cervera-Acevedo, Sonia Santibañez, Aránzazu Portillo, José A. Oteo, Salim Mattar   +6 more
doaj   +1 more source

Using a Syrian (Golden) Hamster Biological Model for the Evaluation of Recombinant Anthrax Vaccines

Life, 2021
In this paper, we demonstrate that a Syrian hamster biological model can be applied to the study of recombinant anthrax vaccines. We show that double vaccination with recombinant proteins, such as protective antigen (PA) and fusion protein LF1PA4 ...
Tatiana Kravchenko, Galina Titareva, Irina Bakhteeva, Tatiana Kombarova, Alexander Borzilov, Raisa Mironova, Kseniya Khlopova, Vitalii Timofeev   +7 more
doaj   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

The H2S–Nrf2–Antioxidant Proteins Axis Protects Renal Tubular Epithelial Cells of the Native Hibernator Syrian Hamster from Reoxygenation-Induced Cell Death

Biology, 2019
During hibernation, repeated cycles of ischemia-reperfusion (I-R) leave vital organs without injury. Studying this phenomenon may reveal pathways applicable to improving outcomes in I-R injury-induced human diseases.
Theodoros Eleftheriadis, Georgios Pissas, Evdokia Nikolaou, Vassilios Liakopoulos, Ioannis Stefanidis   +4 more
doaj   +1 more source

Efficient gene targeting in golden Syrian hamsters by the CRISPR/Cas9 system. [PDF]

PLoS ONE, 2014
The golden Syrian hamster is the model of choice or the only rodent model for studying many human diseases. However, the lack of gene targeting tools in hamsters severely limits their use in biomedical research.
Zhiqiang Fan, Wei Li, Sang R Lee, Qinggang Meng, Bi Shi, Thomas D Bunch, Kenneth L White, Il-Keun Kong, Zhongde Wang   +8 more
doaj   +1 more source

Exacerbated Hepatic Stress and Systemic Metabolic Disruption Driven by SARS‐CoV‐2 P.1 Variant in K18‐hACE2 Mice

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Introduction While severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been extensively studied in the context of pulmonary disease, its impact on metabolic organs remains poorly understood, particularly across experimental models.
Monara Kaélle Sérvulo Cruz Angelim, Patrícia Brito Rodrigues, Antônio Thiago Pereira Campos, Giovanni Freitas Gome, Gabriela Fabiano Souza, Valquíria Aparecida Matheus, Carlos Lenz Cesar, José Luiz Proença‐Módena, Marco Aurélio R. Vinolo, Pedro M. Moraes‐Vieira   +9 more
wiley   +1 more source

Video_1_Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.mp4

, 2023
IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, but preclinical testing of hypotheses such as combination therapies has been complicated, in part due to species incompatibility issues.
Marjukka Anttila (39928), Camilla Heiniö (11175855), Saru Basnet (10817676), Akseli Hemminki (95128), Victor Arias (14563064), Víctor Cervera-Carrascon (14563058), Dafne C. A. Quixabeira (10817661), James H. A. Clubb (12203420), Lyna Haybout (14563055), Katri Aro (12203435), Suvi Sorsa (11175864), Tapani Viitala (450899), Mykhailo Girych (14563052), Annabrita Hemmes (14563061), Anna Kanerva (95120), Susanna Grönberg-Vähä-Koskela (759913), Abdullah Erikat (14563073), Shreyas Kaptan (14563070), Vincenzo Cerullo (48487), Firas Hamdan (11519483), Elise Jirovec (14563067), Santeri Pakola (12203423), João Manuel Santos (12203429), Joel Schwartz (18324), Tatiana V. Kudling (10817673), Riikka Havunen (10817670), Ilpo Vattulainen (188193)   +26 more
core   +1 more source