Results 111 to 120 of about 815,105 (301)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Honey as Topical Dressing in Chronic Wound: A Systematic Review

International Journal of Science and Research (IJSR), 2021
Komang Abdi Baskara Mayun, Ida Yustiana, IB Pramana Suaryasa, I Made Adipta Adiputra   +3 more
openaire   +1 more source

Assessment of a method to detect signals for updating systematic reviews. [PDF]

, 2014
BackgroundSystematic reviews are a cornerstone of evidence-based medicine but are useful only if up-to-date. Methods for detecting signals of when a systematic review needs updating have face validity, but no proposed method has had an assessment of ...
Johnsen, Breanne, Motala, Aneesa, Newberry, Sydne J, Shekelle, Paul G   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Topical insulin as a novel treatment for persistent epithelial defects and other ocular surface disorders: a systematic review

Graefe's Archive for Clinical and Experimental Ophthalmology
Through this systematic review, we evaluated the therapeutic potential of topical eye insulin in different concentrations to treat several surface ocular pathologies, including: persistent epithelial defects, diabetic keratopathy after a vitrectomy, neutrophic keratopathy and dry eye syndrome.
Raluca Bievel Radulescu, Stefano Ferrari, Horia T. Stanca, Diego Ponzin   +3 more
openaire   +3 more sources

Compliance of systematic reviews in veterinary journals with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) literature search reporting guidelines

Journal of the Medical Library Association, 2017
Objective: Complete, accurate reporting of systematic reviews facilitates assessment of how well reviews have been conducted. The primary objective of this study was to examine compliance of systematic reviews in veterinary journals with Preferred ...
Lorraine C. Toews
doaj   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. [PDF]

, 2011
BACKGROUND: Stroke is the major cause of adult disability. Selective serotonin reuptake inhibitors (SSRIs) have been used for many years to manage depression.
Anne Claxton, Cheng-Fang Hsieh, Gillian E Mead, Graeme J Hankey, Mansur A Kutlubaev, Maree L Hackett, Rebecca Lee   +6 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Delivering rapid, up-to-date, high-quality evidence is feasible during health emergencies: PAHO living systematic review of 305 COVID-19 potential therapeutics

Revista Panamericana de Salud Pública
Objective. To develop a living systematic review to deliver continuous, real-time evidence synthesis in the context of a rapidly evolving landscape of studies on potential therapeutic interventions during the COVID-19 pandemic. Methods.
Ariel Izcovich, Sasha Peiris, Gabriel Rada, Fernando Tortosa, Martín Ragusa, Ludovic Reveiz   +5 more
doaj   +1 more source

Systematic reviews: a cross-sectional study of location and citation counts

BMC Medicine, 2003
Background Systematic reviews summarize all pertinent evidence on a defined health question. They help clinical scientists to direct their research and clinicians to keep updated.
Morgan Douglas, Wilczynski Nancy L, Montori Victor M, Haynes R Brian   +3 more
doaj   +1 more source