Results 111 to 120 of about 56,728,962 (299)

The number of papers from the two systematic reviews included in the analysis by geographic location and topic.

, 2016
The number of papers from the two systematic reviews included in the analysis by geographic location and topic.
Gary J. Fooks (490319), Selda Ulucanlar (542541), Anna B. Gilmore (235468)   +2 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Quality of reporting in systematic reviews of adverse events: systematic review

, 2014
To examine the quality of reporting of harms in systematic reviews, and to determine the need for a reporting guideline specific for reviews of ...
Loke, Y., Oh, B., K. Pilkington, Joffe, Ari, Golder, Su, Hartling, L., Mullan, Barbara, S. Vohra, Pilkington, K., Davis, E., Vohra, S., S. Golder, Zorzela, Liliane, L. Hartling, L. Zorzela, Hartling, Lisa, Zorzela, L., A. Joffe, Loke, Yoon, Clarke, S., Liu, Y., Vohra, Sunita, Golder, S., Liu, Yali, Butow, P., Y. Loke, Joffe, A., Y. Liu, Pilkington, Karen   +28 more
core   +1 more source

Assessing quality in systematic reviews of the effectiveness of health promotion: areas of consensus and dissension

, 2009
Systematic reviews have played an increasingly important role in health promotion in recentyears. Yet there are debates about how they should be conducted, particularly about how thequality of evidence should be assessed.
Shepherd, Jonathan Paul
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Enhancing the quality of systematic reviews and meta-analyses

Systematic reviews and meta-analyses are often considered the highest level in evidence hierarchies, and therefore are often drawn upon when considering changes in policy. Despite journals implementing measures aiming to enhance the quality of systematic
Strawbridge, Rebecca, Cristea, Ioana A., Sharma, Deepika, Kisely, Steve, Kaufman, Kenneth R., Young, Allan H.   +5 more
core   +1 more source

Effects of metformin on head and neck cancer: an umbrella review

BMC Cancer
Background Metformin is a commonly used antihyperglycemic drug to treat type 2 diabetes mellitus worldwide. However, its effectiveness was recently documented beyond diabetic treatment, such as in the case of cancer.
Vini Mehta, Javier Flores Fraile, Ankita Mathur, Mahati Bhadania, Cosimo Galletti   +4 more
doaj   +1 more source

Delivering rapid, up-to-date, high-quality evidence is feasible during health emergencies: PAHO living systematic review of 305 COVID-19 potential therapeutics

Revista Panamericana de Salud Pública
Objective. To develop a living systematic review to deliver continuous, real-time evidence synthesis in the context of a rapidly evolving landscape of studies on potential therapeutic interventions during the COVID-19 pandemic. Methods.
Ariel Izcovich, Sasha Peiris, Gabriel Rada, Fernando Tortosa, Martín Ragusa, Ludovic Reveiz   +5 more
doaj   +1 more source

Compliance of systematic reviews in veterinary journals with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) literature search reporting guidelines

Journal of the Medical Library Association, 2017
Objective: Complete, accurate reporting of systematic reviews facilitates assessment of how well reviews have been conducted. The primary objective of this study was to examine compliance of systematic reviews in veterinary journals with Preferred ...
Lorraine C. Toews
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source