Results 131 to 140 of about 815,105 (301)

Towards Evidence-Based Sustainable Communities: Report on Survey of Urban Sustainability Centers in U.S. Universities [PDF]

, 2011
Provides an overview of characteristics of urban sustainability research centers, including organizational structure, personnel capacity, finances, current objectives, and recent research topics.
Genevieve Giuliano, Hilda Blanco
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dietary fiber consumption and outcomes of different cancers: an umbrella review

Food & Nutrition Research
Background: The relationship between dietary fiber intake and cancer outcomes, including incidence, recurrence, and mortality, is crucial for understanding cancer prevention strategies.
Xingyu He, Jiayi Hou, Lei Liu, Xin Chen, Lijie Zhang, Caojia Pang, Yu Tong, Hongling Li, Feng Chen, Rong Peng, Zheng Shi   +10 more
doaj   +1 more source

An AMSTAR assessment of the methodological quality of systematic reviews of oral healthcare interventions published in the Journal of Applied Oral Science (JAOS)

Journal of Applied Oral Science, 2011
BACKGROUND: Systematic reviews are not an assembly of anecdotes but a distillation of current best available evidence on a particular topic and as such have an important role to play in evidence-based healthcare.
Patrick Sequeira-Byron, Zbys Fedorowicz, Vanitha A. Jagannath, Mohammad Owaise Sharif   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The new rehabilitation definition for research purposes could improve rehabilitation description in Cochrane Systematic Reviews

Cochrane Evidence Synthesis and Methods
Introduction In 2022, Cochrane Rehabilitation developed a new definition of rehabilitation for research purposes with 80 global stakeholders, aiming to support and improve the production and reporting of primary and evidence‐synthesis rehabilitation ...
Irene Battel, Chiara Arienti, William Levack, Carlotte Kiekens, Stefano Negrini   +4 more
doaj   +1 more source

Baricitinib as monotherapy and with topical corticosteroids in moderate-to-severe atopic dermatitis: a systematic review and meta-analysis of dose-response

Frontiers in Allergy
IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disorder that affects millions worldwide, presenting challenges in managing symptoms and quality of life. Current treatments include topical corticosteroids (TCS), but novel approaches, such as Janus kinase (JAK) inhibitors, show promise. Baricitinib, a selective JAK1 and JAK2 inhibitor,
Ibrahim H. I. Almoghayer, Abdul Mateen Soomro, Shah Dev, Muskan Turesh, Ateesh Kumar, Ravi Kumar, Aashish Meghjiani, Syeda Lamiya Mir, Muhammad Hassaan, Rehan Qureshi, Vishal Kumar, Taimoor Ashraf, F. N. U. Deepak, Mohammad Arham Siddiq, Abdul Haseeb, Ayush Kumar   +15 more
openaire   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Knowledge and Attitudes of Dental Professionals and Students on MIH: A Scoping Review

Acta Stomatologica Croatica
Objective: This scoping review aimed to map the knowledge, perceptions, and attitudes of dental professionals and students regarding MIH. Materials and Methods: A systematic search was conducted in the electronic databases MEDLINE/PubMed, Scopus, Web of ...
Juan Sebastian Lara, Manuel Restrepo, Jose Luis Ureña-Cirett, Janina Rodrigues, Nathalia Araujo Bim, Bruna Bergamo Campoi, Esperanza Ángeles Martínez-Mier, Tamara Kerber Tedesco   +7 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source