Results 121 to 130 of about 53,975,838 (284)

The new rehabilitation definition for research purposes could improve rehabilitation description in Cochrane Systematic Reviews

Cochrane Evidence Synthesis and Methods
Introduction In 2022, Cochrane Rehabilitation developed a new definition of rehabilitation for research purposes with 80 global stakeholders, aiming to support and improve the production and reporting of primary and evidence‐synthesis rehabilitation ...
Irene Battel, Chiara Arienti, William Levack, Carlotte Kiekens, Stefano Negrini   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Knowledge and Attitudes of Dental Professionals and Students on MIH: A Scoping Review

Acta Stomatologica Croatica
Objective: This scoping review aimed to map the knowledge, perceptions, and attitudes of dental professionals and students regarding MIH. Materials and Methods: A systematic search was conducted in the electronic databases MEDLINE/PubMed, Scopus, Web of ...
Juan Sebastian Lara, Manuel Restrepo, Jose Luis Ureña-Cirett, Janina Rodrigues, Nathalia Araujo Bim, Bruna Bergamo Campoi, Esperanza Ángeles Martínez-Mier, Tamara Kerber Tedesco   +7 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Wastewater-Based Epidemiology for Infectious Disease Surveillance: A Systematic Review and Meta-Analysis Focused on SARS-Cov-2, with Narrative Synthesis for Other Pathogens [PDF]

Journal of Environmental Health and Sustainable Development
Introduction: Wastewater-based epidemiology (WBE) has emerged as a valuable approach for environmental management and public health surveillance. By detecting viral RNA and biomarkers in wastewater, WBE provides community-level early warning signals that
Soleiman Forouzandeh, Amin Salehi-Abargouei, Ali Asghar Ebrahimi   +2 more
doaj  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Cognitive Deficits in Persons with Functional Pain Syndrome: A Systematic Review

Indian Journal of Pain
Background: Functional pain syndromes (FPSs) may have an incapacitating cognitive and psychological effect on daily life, with emerging and inconsistent evidence suggesting long-term pain may impact various cognitive domains.
Ashwini Tadpatrikar, Vrinda Marigowda, Manoj Kumar Sharma, Rashmi Arasappa, Binukumar Bhaskarapillai, Bindu M. Kutty, Santosh K. Chaturvedi, Geetha Desai   +7 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source