Results 81 to 90 of about 815,105 (301)

Risk of postoperative pulmonary complications in adult surgical patients with metabolic syndrome: a systematic review and meta-analysis protocol [PDF]

, 2019
Background: Metabolic syndrome (MetS) is defined as an accumulation of risk factors that include chronic hypertension, dyslipidaemia, insulin resistance and obesity and leads to an increased risk for diabetes, cardiovascular disease and stroke.
Gow, Jeffrey, Norris, Philip, Ralph, Nicholas, Silvey, Natalie, Viljoen, Bianca   +4 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Development and validation of high-sensitivity and high-specificity pubmed search filters for systematic and non-systematic reviews

BMC Medical Research Methodology
Objective To develop and compare the accuracy of different PubMed search strategies (filters) for systematic and non-systematic reviews in dental journals. Methods This validation study included articles published in 2019 in 15 dental journals.
Victor Nascimento Fontanive , Letícia Possebon Müller , Federico Riva, Mariana Seoane, Roger Keller Celeste   +4 more
doaj   +1 more source

The 2016 HIGh Heels: Health effects and psychosexual benefITS (HIGH HABITS) study : systematic review of reviews and additional primary studies [PDF]

, 2017
Acknowledgements We thank S.M. Barran (Guy’s and St Thomas NHS Foundation Trust) for general comments on the topic and its social context. We thank S. Reynolds for comments as a member of the public on the introduction and discussion, in particular with ...
Barnish, Jean, Barnish, Max, Morgan, Heather May   +2 more
core   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Mapping and systematic appraisal of umbrella reviews in epidemiological research: a protocol for a meta-epidemiological study

Systematic Reviews, 2023
Introduction Umbrella review is one of the terms used to describe an overview of systematic reviews. During the last years, a rapid increase in the number of umbrella reviews on epidemiological studies has been observed, but there is no systematic ...
Lazaros Belbasis, Robin D Brooker, Emmanuel Zavalis, Angelo Maria Pezzullo, Cathrine Axfors, John PA Ioannidis   +5 more
doaj   +1 more source

Novel Gel Techniques for Meloxicam Transdermal Administration as Topical Gel: A Systematic Review

International Journal of Pharmaceutical Research and Applications
A potential non-steroidal anti-inflammatory medication (NSAID) for the prevention and treatment of both acute and chronic pain is meloxicam. Meloxicam has limited therapeutic application because of its weak water solubility. Furthermore, it is challenging to develop a suitable NSAID-based delivery system that can pass through the skin barrier for ...
Deepak Kumar Pandey, Dr. Jai Narayan Mishra, Ashutosh Kushwaha, Dhaneshwar Kumar Vishwakarma   +3 more
openaire   +1 more source

Weight of evidence: a framework for the appraisal of the quality and relevance of evidence [PDF]

, 2007
Knowledge use and production is complex and so also are attempts to judge its quality. Research synthesis is a set of formal processes to determine what is known from research in relation to different research questions and this process requires ...
Gough, David
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Doing data analysis [PDF]

, 2010
'Research is about more than empirical evidence, but evidence is at the heart of finding out more about the social and education world. One way of marshalling evidence on a topic, or to answer a research question, is to use the findings of others as ...
Gorard, Stephen
core