Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney
Ferroptosis resistance is vital for B cell development, especially in inflammatory diseases, yet the underlying mechanism is still unclear. In this study, based on the scRNA-seq technique and flow cytometry, we discovered a proportion of neutrophils ...
Zechen Wang +9 more
doaj +1 more source
Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer
Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process.
Yanfei Ma +14 more
doaj +1 more source
Clinical Status of Cardiac Rehabilitation Manners and Models
Cardiac rehabilitation, which combines cardiology and preventive medicine, is an important part of treatment for cardiovascular diseases. Systematically, cardiac rehabilitation, including simultaneously inhibiting endothelial injury and promoting ...
Wei Wei +10 more
doaj +1 more source
IL-2-Agonist-Induced IFN-γ Exacerbates Systemic Anaphylaxis in Food Allergen-Sensitized Mice
Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of ...
Christopher W.M. Link +14 more
doaj +1 more source
Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases.
Zhengfang Liang +6 more
doaj +1 more source
Anaphylatoxins spark the flame in early autoimmunity
The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher +3 more
doaj +1 more source
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection
Toxoplasma gondii (T. gondii) is a parasite infecting animals and humans. In intermediate hosts, such as humans or rodents, rapidly replicating tachyzoites drive vigorous innate and adaptive immune responses resulting in bradyzoites that survive within ...
Daria Briukhovetska +8 more
doaj +1 more source
IL-10 revisited in systemic lupus erythematosus
IL-10 is a cytokine with pleiotropic functions, particularly known for its suppressive effects on various immune cells. Consequently, it can limit the pathogenesis of inflammatory diseases, such as multiple sclerosis (MS), inflammatory bowel disease ...
Swayanka Biswas +2 more
doaj +1 more source
Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis
Objectives. Sepsis is characterized as a dysregulated host immune response to infection and has been known to be closely associated with the gut microbiome.
Jieyang Yu +8 more
doaj +1 more source
The Melanocortin System in Control of Inflammation [PDF]
Melanocortin peptides, the collective term for α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient modulatory system. Natural melanocortins derive from the common precursor pro-opiomelanocortin (POMC). Five receptor subtypes for melanocortins (MC1-MC5) are widely distributed in
A. Catania +5 more
openaire +4 more sources

