Results 121 to 130 of about 2,603,757 (311)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Persistent high fever and systemic inflammation induced by percutaneous coronary intervention-related periaortitis

, 2009
Takamori Kakino, Tomohiro Nakayama, Hideo YamamotoDepartment of Cardiology and Radiology, Kyushu Kosei–Nenkin Hospital, Kitakyushi City, JapanAbstract: After coronary catheterization, fever sometimes occurs, usually transiently.
Takamori Kakino, Hideo Yamamoto, Tomohiro Nakayama   +2 more
core  

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation [Elektronisk resurs]

, 2015
Several organs in the body comprise cells coupled into networks. These cells have in common that they are excitable but do not express action potentials.
Sveriges lantbruksuniversitet., Skiöldebrand, Eva,   +1 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Histopathological and Immunohistochemical Investigation of the Effects of Methylprednisolone Administration on Some Pro-inflammatory Cytokine Levels in Mouse Kidney Tissue in a Systemic Chronic Inflammation Model

Systemic chronic inflammation may cause kidney injury as a result of an impaired immune response and pro-inflammatory cytokine overload due to various factors that prevent the resolution of inflammation.
Aykut ULUCAN
core   +1 more source

Use of electronic health records to investigate the role of acute inflammation and infection in vascular disease [PDF]

Previous studies have demonstrated that acute systemic inflammation after surgery or infection is associated with a transient increase in the risk of vascular events. This suggests that vascular risk is not stable but fluctuates within short periods in
Minassian, C
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

The grand escape – how pathogens outsmart the human complement system

Immunobiology
Infectious diseases remain a significant cause of mortality and morbidity worldwide. Complement is a critical component in the defense against pathogens and despite their great differences, viruses, bacteria, fungi, and protists have all developed ...
A.A. Nowacka, L. Sordo Vieira, V. Petr, B. Fageräng, R. Würzner, M. Ohms   +5 more
doaj   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source