Results 81 to 90 of about 2,406,544 (309)

Complement activation and cellular inflammation in Fabry disease patients despite enzyme replacement therapy

Frontiers in Immunology
Defective α-galactosidase A (AGAL/GLA) due to missense or nonsense mutations in the GLA gene results in accumulation of the glycosphingolipids globotriaosylceramide (Gb3) and its deacylated derivate globotriaosylsphingosine (lyso-Gb3) in cells and body ...
Björn Laffer, Malte Lenders, Elvira Ehlers-Jeske, Karin Heidenreich, Eva Brand, Jörg Köhl, Jörg Köhl   +6 more
doaj   +1 more source

Influence of moisture content, temperature, and time on free fatty acid in stored crude palm oil

Scientific Reports, 2022
Consequent to the importance of crude palm oil (CPO) to global food processing industries, and the need for quality assurance of CPO. A kinetic model that describes changes of free fatty acid (FFA) in industrially stored CPO has been developed.
Samuel Emebu, Omokaro Osaikhuiwuomwan, Aleksi Mankonen, Chinweike Udoye, Charity Okieimen, Dagmar Janáčová   +5 more
doaj   +1 more source

Skin Inflammation, Systemic Inflammation, and Cardiovascular Disease in Psoriasis

JAMA Dermatology
ImportancePsoriasis is associated with increased cardiovascular risk, but the underlying pathogenic mechanisms remain unclear. Elucidating these mechanisms can help develop treatment strategies and enhance understanding of the link between peripheral inflammation, such as psoriatic skin lesions, and cardiovascular disease (CVD).ObjectiveTo explore ...
Svedbom, Axel, Mallbris, Lotus, González-Cantero, Álvaro, Playford, Martin, Wu, Colin, Mehta, Nehal N., Ståhle, Mona   +6 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Exploring the role of CD8+ T cells in clear renal cell carcinoma metastasis

FEBS Open Bio
Clear cell renal cell carcinoma (ccRCC) accounts for approximately 75–80% of all patients with renal cell carcinoma. Despite its prevalence, little is known regarding the key components involved in ccRCC metastasis.
Yuanhong Chen, Jiajia Shen, Caixia Ling, Zhengfang Liang, Shaoang Huang, Wenxian Lin, Yujuan Qin, Lingzhang Meng, Yanhong Luo   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tocilizumab in treatment-naïve patients with Takayasu arteritis: TOCITAKA French prospective multicenter open-labeled trial

Arthritis Research & Therapy, 2020
Objectives To assess long-term efficacy of tocilizumab in treatment-naive patients with Takayasu arteritis (TAK). Methods Prospective open-labeled trial in naïve patients with TAK who received steroids at the dose of 0.7 mg/kg/day and 7 infusions of 8 mg/
Arsene Mekinian, David Saadoun, Eric Vicaut, Sara Thietart, Bertrand Lioger, Patrick Jego, Alexandre Bleibtreu, Nicolas Limal, Jerome Connault, Jacques-Eric Gottenberg, Pauline Lhorte, Jean Pierre Bertola, Juliette Delforge, Nicole Ferreira-Maldent, Antoinette Perlat, Zohra Talib, Matthieu Vautier, Léa Savey, Isabelle Quiere, Patrice Cacoub, Olivier Fain, for the French Takayasu network   +21 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Clinical value of systemic immune inflammation and pan-immune inflammation in adenoid hypertrophy [PDF]

Aim: This study aimed to investigate the relationship between adenoid hypertrophy, the most common cause of obstructive sleep apnea (OSA) in children, with the systemic immune inflammation index (SII) and the pan-immune inflammation value (PIV), and to ...
Tuğba Yemiş, Askeroğlu, Erdal Eren, Erdal Eren Askeroğlu, Yemiş, Tuğba, Mehmet Birinci, Gökçe Aydın Balaban, Birinci, Mehmet, Çeliker, Metin, Erdivanlı, Özlem Çelebi, Balaban, Gökçe Aydın, Metin Çeliker, Özlem Çelebi Erdivanlı   +11 more
core   +1 more source

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]

, 2015
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Davari, M, Yiannis Ioannou, Isenberg, D, Paul Bassett, Rahman, A, David Isenberg, Anisur Rahman, Maria Davari, Alber, KF, Ioannou, Y, Oliver Leach, Giles, I, Bassett, P, Karim Alber, Ian Giles, Leach, O, Sara Croca, Chambers, S, Croca, S, Sharon Chambers   +19 more
core   +1 more source