Results 1 to 10 of about 28,304 (252)

Systemic lupus erythematosus with juvenile onset: current status of the problem (literature review)

Современная ревматология
Patients with juvenile-onset systemic lupus erythematosus (jSLE) account for up to 25% of all SLE patients. The main difference between jSLE and SLE in adults is the greater role of genetic factors in the pathogenesis, higher activity, earlier ...
M. I. Kaleda, I.  P. Nikishina
doaj   +3 more sources

Clinical variants of skin and mucous membrane lesions in systemic lupus erythematosus with juvenile onset

Современная ревматология, 2023
Skin and mucous membrane lesions are frequently seen in systemic lupus erythematosus (SLE) with the juvenile onset (juSLE), and they are extremely diverse.
M. I. Kaleda, S. O. Salugina, I. P. Nikishina, A. N. Arefieva   +3 more
doaj   +3 more sources

Risk factors for subsequent lupus nephritis in patients with juvenile-onset systemic lupus erythematosus: a retrospective cohort study

Pediatric Rheumatology Online Journal, 2023
Background Lupus nephritis (LN) is a crucial organ involvement in systemic lupus erythematosus (SLE). Patients with LN have higher morbidity and mortality rates than those without.
Tzu-Chuan Hsu, Yao-Hsu Yang, Li-Chieh Wang, Jyh-Hong Lee, Hsin-Hui Yu, Yu-Tsan Lin, Ya-Chiao Hu, Bor-Luen Chiang   +7 more
doaj   +4 more sources

Quality of life in patients with juvenile-onset systemic lupus erythematosus

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem, and potentially life-threatening autoimmune disease with significant comorbidities and the development of a chronic, debilitating condition for the patient.
L.F. Bohmat, N.S. Shevchenko, I.M. Bessonova, T.O. Holovko   +3 more
doaj   +3 more sources

Belimumab in a Patient with Systemic Lupus Erythematosus with Juvenile Onset and Steroid-induced Diabetes: Clinical Case

Вопросы современной педиатрии, 2023
Background. The management of children with systemic lupus erythematosus (SLE) is usually associated with lifelong systemic glucocorticoids administration and, thereby, high risk of serious side effects, including steroid-induced diabetes. The belimumab (
Maria I. Kaleda, Irina P. Nikishina, Alesya V. Firsa   +2 more
doaj   +3 more sources

Elevated serum interferon-α2 associates with activity and flare risk in juvenile-onset systemic lupus erythematosus. [PDF]

Rheumatology (Oxford)
Abstract Objectives This study investigated serum IFN-α2 as a putative marker of disease activity and predictor of disease flares in juvenile systemic lupus erythematosus (jSLE). Methods A total of 222 serum samples were analysed ...
Natoli V, Crow YJ, Hunt DPJ, Tharmaratnam K, Jorgensen AL, Beresford MW, Hedrich CM, Smith EMD.   +7 more
europepmc   +4 more sources

Associations of lymphocyte subpopulations with clinical phenotypes and long-term outcomes in juvenile-onset systemic lupus erythematosus.

PLoS ONE, 2022
ObjectiveJuvenile-onset systemic lupus erythematosus (JSLE) is a complex and heterogeneous immune-mediated disease. Cellular components have crucial roles in disease phenotypes and outcomes.
Butsabong Lerkvaleekul, Nopporn Apiwattanakul, Kanchana Tangnararatchakit, Nisa Jirapattananon, Supanart Srisala, Soamarat Vilaiyuk   +5 more
doaj   +5 more sources

Transition Readiness in Adolescents With Juvenile Idiopathic Arthritis and Childhood‐Onset Systemic Lupus Erythematosus [PDF]

ACR Open Rheumatology, 2021
Objective The transition from pediatric to adult rheumatology care represents a particularly vulnerable time for patients with juvenile idiopathic arthritis (JIA) and childhood‐onset systemic lupus erythematosus (cSLE).
Jeanine McColl, Teresa Semalulu, Karen A. Beattie, Arzoo Alam, Steffy Thomas, Julie Herrington, Jan Willem Gorter, Tania Cellucci, Stephanie Garner, Liane Heale, Mark Matsos, Michelle Batthish   +11 more
doaj   +3 more sources

Case Report: Novel UNC93B1 variant causes rheumatoid arthritis and interstitial pneumonia [PDF]

Frontiers in Immunology
BackgroundUNC93B1 is a transmembrane protein essential for regulating toll-like receptors (TLRs). Pathogenic variants in human UNC93B1 have recently been described in a limited number of patients with childhood systemic lupus erythematosus and chilblain ...
Tingyan He, Junbin Ou, Lijuan Huang, Xinyi Zhou, Linlin Wang, Xiaolin Li, Jun Yang   +6 more
doaj   +2 more sources

Belimumab in the treatment of systemic lupus erythematosus with juvenile onset: Results of a single-center retrospective study

Научно-практическая ревматология
The treatment of systemic lupus erythematosus with juvenile onset (jSLE) remains a difficult task, taking into account the more aggressive course of the disease, requiring the appointment of various therapy regimens, including mainly a combination of ...
Maria I. Kaleda, Irina P. Nikishina, Tamari N. Pachkoria, Anna N. Shapovalenko   +3 more
doaj   +2 more sources