Results 11 to 20 of about 28,304 (252)

An Unprecedented Triad: Simultaneous Acute Pancreatitis, Axonal Polyneuropathy, and Type 1 Diabetes Mellitus in a Catastrophic Juvenile Lupus Flare [PDF]

Clinical Case Reports
A 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D ...
Laiba Hashmi, Fazeela Bibi, Kishan Chand Lohana, Khalil El Abdi, Zonaira Mushahid, Muhammad Asad Asif, Mahnoor Ilyas, Osvani Leyva Matos, Ariba Munam, Muhammad Saad Sammi, Samaha Kanden Mohammed Shafi, Said Hamid Sadat   +11 more
doaj   +3 more sources

Juvenile-onset Systemic Lupus Erythematosus: Recent Advances in Pathogenesis and Treatment. [PDF]

Curr Rheumatol Rep
This review summarizes recent advances in understanding the pathogenesis and therapeutic landscape of juvenile-onset systemic lupus erythematosus (jSLE), with a focus on how emerging genetic and immunologic insights inform patient stratification ...
Natoli V, Charras A, Smith EM, Hedrich CM.   +3 more
europepmc   +2 more sources

Musculoskeletal symptoms in juvenile onset systemic lupus erythematosus

Современная ревматология, 2023
In juvenile onset systemic lupus erythematosus (SLE), musculoskeletal involvement is one of the most common manifestations. Musculoskeletal symptoms may be due to disease activity itself, organ damage due to SLE activity, drug exposure, or comorbidities.
M. I. Kaleda, A. N. Arefieva, I. P. Nikishina   +2 more
doaj   +2 more sources

OA21 Juvenile onset systemic lupus erythematosus: a pair of siblings [PDF]

Rheumatol Adv Pract
We present the cases of two siblings both of whom were born in Goa to non-consanguineous parents with juvenile onset systemic lupus erythematosus (jSLE) with differing clinical and laboratory features. Patient 1: Presented acutely in 2022 at
Rosemary Waller, Inga Turtsevich
europepmc   +2 more sources

Severe Juvenile-Onset Systemic Lupus Erythematosus: A Case Series-Based Review and Update

Children, 2023
Juvenile-onset systemic lupus erythematosus (jSLE) is a multisystemic disease diagnosed in young patients based on the clinical criteria of the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR).
Sergi Huerta-Calpe, Ignacio Del Castillo-Velilla, Aida Felipe-Villalobos, Iolanda Jordan, Lluïsa Hernández-Platero   +4 more
doaj   +2 more sources

Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients [PDF]

The Turkish Journal of Pediatrics, 2017
Juvenile-onset systemic lupus erythematosus (JSLE) is a complex autoimmune disease, characterized by multi-organ involvement. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene have been reported to
Arash Salmaninejad, Mahdi Mahmoudi, Saeed Aslani, Shiva Poursani, Vahid Ziaee, Nima Rezaei   +5 more
doaj   +3 more sources

Association of rs7574865 G/T polymorphism of STAT4 gene with juvenile onset of systemic lupus erythematosus

Современная ревматология, 2022
Systemic lupus erythematosus (SLE) with juvenile onset (jSLE) is a complex autoimmune disease involving many organs and systems. The single nucleotide polymorphism rs7574865 of the STAT4 (signal switch and transcription activator 4) gene is associated ...
M. Yu. Krylov, M. I. Kaleda, I. A. Guseva, N. V. Konovalova, D. A. Varlamov   +4 more
doaj   +3 more sources

OA08 Ocrelizumab in pregnancy in a patient with juvenile onset systemic lupus erythematosus

Rheumatology Advances in Practice
Abstract Introduction Juvenile-onset systemic lupus erythematosus (jSLE) is a multisystem autoimmune disease that results in increased disease activity compared to adult-onset SLE. jSLE in pregnancy results in a greater incidence of disease flares as well as adverse pregnancy outcomes.
Suleman-Raza, Yasir, Sen, Debajit, Fisher, Corinne, Mouyis, Maria   +3 more
openaire   +2 more sources

Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)

Molecular and Cellular Pediatrics, 2023
Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE).
Valentina Natoli, Amandine Charras, Gabriele Hahn, Christian M. Hedrich   +3 more
doaj   +2 more sources

Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement

Frontiers in Immunology
BackgroundLupus pathogenesis is mainly ascribed to increased production and/or impaired clearance of dead cell debris. Although self-reactive T and B lymphocytes are critically linked to lupus development, neutrophils, monocytes, and natural killer (NK ...
Bernadete L. Liphaus, Bernadete L. Liphaus, Simone C. Silva, Patrícia Palmeira, Clovis A. Silva, Clovis A. Silva, Claudia Goldenstein-Schainberg, Magda Carneiro-Sampaio   +7 more
doaj   +2 more sources