Results 1 to 10 of about 1,282,511 (265)
Italian Journal of Pediatrics, 2023 Background Pediatric Mastocytosis is a rare and heterogeneous disease, characterized by accumulation of mast cells in the skin (Cutaneous Mastocytosis) and/or, less frequently, in other organs, mainly liver, spleen, bone marrow, lymph nodes and ...
Grazia Bossi +9 more
doaj +2 more sources
Scientific Reports, 2022 Mastocytosis is a rare myeloproliferative disease, characterised by accumulation of neoplastic mast cells in one or several organs. It presents as cutaneous or systemic.
R. L. J. Graham +5 more
doaj +2 more sources
Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial
Nature Medicine, 2021 Advanced systemic mastocytosis (AdvSM) is a rare hematologic neoplasm driven by the KIT D816V mutation and associated with poor survival. This phase 1 study (NCT02561988) evaluated avapritinib (BLU-285), a selective KIT D816V inhibitor, in patients with ...
Daniel J Deangelo +2 more
exaly +2 more sources
Nature Medicine, 2021 Advanced systemic mastocytosis (AdvSM) is a rare, KIT D816V-driven hematologic neoplasm characterized by mast cell infiltration and shortened survival.
Jason Gotlib +2 more
exaly +2 more sources
Delayed Diagnosis of Indolent Systemic Mastocytosis as the Cause of Unexplained Skin Rash: A Case Report [PDF]
Case Reports in Oncology, 2023 Mastocytosis is a heterogeneous group of disorders in which mast cells exhibit clonal proliferation that infiltrates one or more organs. In cutaneous mastocytosis, the mast cells infiltrate the skin only, whereas systemic mastocytosis is diagnosed when ...
Awni Alshurafa +4 more
doaj +2 more sources
Phenotypic and genotypic characteristics of mastocytosis according to the age of onset. [PDF]
PLoS ONE, 2008 Adult's mastocytosis is usually associated with persistent systemic involvement and c-kit 816 mutation, while pediatrics disease is mostly limited to the skin and often resolves spontaneously.
Fanny Lanternier +26 more
doaj +9 more sources
Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management
American Journal of Hematology, 2021 Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in extra‐cutaneous organs.
Animesh D Pardanani
exaly +2 more sources
Adult mastocytosis: a review of the Santo António Hospital 's experience and an evaluation of World Health Organization criteria for the diagnosis of systemic disease [PDF]
Anais Brasileiros de Dermatologia, 2014 BACKGROUND: Mastocytosis is a clonal disorder characterized by the accumulation of abnormal mast cells in the skin and/or in extracutaneous organs. OBJECTIVES: To present all cases of mastocytosis seen in the Porto Hospital Center and evaluate the ...
Iolanda Conde Fernandes +5 more
doaj +4 more sources
Urticaria pigmentosa and systemic mastocytosis [PDF]
Clinical Case Reports, 2023 Key Clinical Message Additional investigations for systemic involvement should be initiated once the diagnosis of cutaneous mastocytosis has been established in an adult patient.
Jonathan Keow +3 more
doaj +2 more sources
Chronic Anaphylaxis With Indolent Systemic Mastocytosis: A Case Report [PDF]
Case Reports in HematologySystemic mastocytosis is a rare, clonal mast cell disease neoplasm driven by the KIT D816V mutation in greater than 95% of cases. The complex clinical presentation of systemic mastocytosis can make diagnosis challenging.
Sarah Worth +4 more
doaj +2 more sources