Results 41 to 50 of about 1,282,511 (265)

Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. [PDF]

, 2018
Diffuse cutaneous mastocytosis (DCM) is a rare but potentially fatal condition when diagnosis and targeted treatments are delayed. This case illustrates the life-threatening complications in DCM and reviews the currently available treatments.
Akin, Alvarez-Twose, Bankova, Bodemer, Brockow, Brockow, Caughey, Chan, Edwards, Escribano, Escribano, Flageul, Fried, Galli, Garg, Hannaford, Hartmann, Has, Heide, Huang, Lange, Melo, Murphy, Orkin, Polk, Poterack, Prieto-García, Smith, Tolar, Valent, Wolff, Zhang, Álvarez-Twose   +32 more
core   +1 more source

Gastrointestinal Manifestations in Systemic Mastocytosis: The Need of a Multidisciplinary Approach

Cancers, 2021
Simple Summary Mastocytosis is a group of neoplastic mast cell disorders ranging from a skin-limited disease to a systemic form with multi-organ involvement, including gut involvement.
M. Zanelli, M. Pizzi, F. Sanguedolce, M. Zizzo, A. Palicelli, A. Soriano, A. Bisagni, Giovanni Martino, C. Caprera, M. Moretti, Francesco Masia, L. De Marco, E. Froio, M. Foroni, G. Bernardelli, M. I. Alvarez de Celis, Alessandro Giunta, F. Merli, S. Ascani   +18 more
semanticscholar   +1 more source

Target Therapies for Systemic Mastocytosis: An Update

Pharmaceuticals, 2022
Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MCs) in extra-cutaneous organs. It could be divided into indolent SM, smoldering SM, SM with an associated hematologic (non-MC lineage) neoplasm, aggressive SM, and ...
M. Sciumè, C. de Magistris, Nicole Galli, E. Ferretti, G. Milesi, P. De Roberto, S. Fabris, F. Grifoni   +7 more
semanticscholar   +1 more source

Biochemical markers predictive for bone marrow involvement in systemic mastocytosis

Haematologica, 2008
Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up. We questioned whether bone marrow involvement could be predicted using biochemical markers.
Marjolein L. Donker, Jasper J. van Doormaal, Frederiek F. van Doormaal, Philip M. Kluin, Eveline van der Veer, Jan G.R. de Monchy, Ido P. Kema, Hanneke C. Kluin-Nelemans   +7 more
doaj   +1 more source

Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]

, 2010
Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P., Sotlar, K., Valent, P.
core   +1 more source

Response Criteria in Advanced Systemic Mastocytosis: Evolution in the Era of KIT Inhibitors

International Journal of Molecular Sciences, 2021
Systemic mastocytosis (SM) is a rare clonal hematologic neoplasm, driven, in almost all cases, by the activating KIT D816V mutation that leads to the growth and accumulation of neoplastic mast cells.
William Shomali, J. Gotlib
semanticscholar   +1 more source

Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms [PDF]

, 1993
Mice were infected either with Trichinella spiralis (day 0), Heligmosomoides polygyrus (day -14) or concurrently with both species and were killed in groups, together with naive control mice, on 2 occasions (day 8 and 15 post infection with T.
Behnke, Jerzy M., Ben-Smith, A.W., Else, K.J., Goyal, P.K., Grencis, R.K., Wahid, F.N.   +5 more
core   +2 more sources

Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis

Theranostics, 2021
In systemic mastocytosis (SM), the clinical features and survival vary greatly. Patient-related factors determining the outcome in SM are largely unknown.
H. Kluin-Nelemans, M. Jawhar, A. Reiter, B. Anrooij, J. Gotlib, Karin, Hartmann, A. Illerhaus, H. Elberink, A. Górska, M. Niedoszytko, M. Lange, L. Scaffidi, R. Zanotti, P. Bonadonna, C. Perkins, C. Elena, Luca, Malcovati, Khalid Shoumariyeh, N. Bubnoff, S. Müller, M. Triggiani, Roberta, Parente, J. Schwaab, M. Kundi, A. B. Fortina, F. Caroppo, K. Brockow, A. Zink, D. Fuchs, I. Angelova-Fischer, A. Yavuz, M. Doubek, Mattias, Mattsson, H. Hagglund, J. Panse, Anne Simonowski, V. Sabato, T. Schug, M. Jentzsch, C. Breynaert, J. Várkonyi, Vanessa E. Kennedy, O. Hermine, J. Rossignol, Michel, Arock, P. Valent, W. Sperr   +51 more
semanticscholar   +1 more source

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal [PDF]

, 2011
Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis.
Akin C, Akin C, Akin C, Alberto Orfao, Alvarez-Twose I, Arock M, Arredondo AR, Austen KF, Awad JA, Bodemer C, Boguslaw Nedoszytko, Bonadonna P, Butterfield JH, Castells MC, Cem Akin, Chin KW, Costa JJ, Daley T, Dean D. Metcalfe, Di Lorenzo G, Donker ML, Finkelman FD, Galli SJ, Garcia-Montero AC, Golden DB, González de Olano D, Hans-Peter Horny, Hogan AD, Horny HP, Johansson SG, Jordan JH, Joseph H. Butterfield, Karin Hartmann, Karl Sotlar, Knut Brockow, Lawrence B. Schwartz, Lieberman P, Luis Escribano, Maintz L, Mariana Castells, Massimo Triggiani, Melody C. Carter, Metcalfe DD, Metcalfe DD, Metcalfe DD, Michel Arock, Morel AM, Murphy S, Nedoszytko B, Peavy RD, Peter Valent, Philip Lieberman, Rivera J, Rudolf Valenta, Ruëff F, Samorapoompichit P, Sampson HA, Schwartz LB, Schwartz LB, Schwartz LB, Schwelberger HG, Serafin WE, Sonneck K, Sperr WR, Vadas P, Valent P, Valent P, Valent P, Valent P, Valent P, van der Donk EM, van Toorenenbergen AW, Webb LM, Wolfgang R. Sperr   +73 more
core   +1 more source

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]

, 2018
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura, Giusti, Pietro, Skaper, Stephen D., Zusso, Morena   +3 more
core   +2 more sources