Results 61 to 70 of about 1,282,511 (265)

Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosis

Blood Advances, 2022
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A. Reiter, J. Schwaab, D. DeAngelo, J. Gotlib, M. Deininger, K. Pettit, I. Alvarez-Twose, A. Vannucchi, J. Panse, U. Platzbecker, O. Hermine, I. Dybedal, Hui-Min Lin, S. Rylova, K. Ehlert, S. Dimitrijević, D. Radia   +16 more
semanticscholar   +1 more source

Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment

Dermatology Practical & Conceptual, 2016
Background: Mastocytosis is either cutaneous (with skin-limited proliferation of mast cells) or systemic (with mast cells in extracutaneous sites). The onset of solitary mastocytoma in an adult is rare.
Philip R. Cohen
doaj   +1 more source

Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis [PDF]

, 2013
Mastocytosis is a rare disease with reported high interleukin-6 (IL6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode IL6 and its receptor (IL6R) in relation to mastocytosis development in a ...
Aladzsity István, Csomor Judit, Falus András, Hidvégi Bernadett, Kokai Márta, Lange M, Lautner-Csorba Orsolya, Marschalkó Márta, Nedoszytko B, Niedoszytko M, Rausz Eszter Zsófia, Szakonyi József, Szilágyi Ágnes, Valent P, Várkonyi Judit   +14 more
core   +1 more source

NCCN Guidelines® Insights: Systemic Mastocytosis, Version 3.2024.

The Journal of the National Comprehensive Cancer Network
Mastocytosis is a heterogeneous group of disorders comprising cutaneous mastocytosis, systemic mastocytosis, and mast cell sarcoma. It is associated with a variety of symptoms related to the release of mast cell mediators and mast cell tissue ...
J. Gotlib, A. Gerds, Peter Abdelmessieh, H. Ali, M. Castells, Andrew Dunbar, Ruth Fein Revell, Tracy I. George, Steven Green, Krishna Gundabolu, Elizabeth O Hexner, Tania Jain, C. Jamieson, P. Kaesberg, Andrew T Kuykendall, Y. Madanat, Naveen Manchanda, L. Masarova, Jori May, Brandon McMahon, Sanjay R Mohan, Kalyan V Nadiminti, Stephen Oh, Jeanne Palmer, Ami Patel, Anand A Patel, Nikolai Podoltsev, Lindsay A M Rein, R. Salit, Moshe Talpaz, M. Wadleigh, Sarah Wall, Mary Anne Bergman, Cindy Hochstetler   +33 more
semanticscholar   +1 more source

Systemic Mastocytosis: Multidisciplinary Approach

Mediterranean Journal of Hematology and Infectious Diseases, 2021
Systemic mastocytosis (SM) is a heterogeneous group of diseases that affect almost exclusively adults and are defined by the proliferation and accumulation of clonal mast cells (MC) in various tissues.
R. Zanotti, I. Tanasi, L. Crosera, M. Bonifacio, D. Schena, G. Orsolini, Francesca Mastropaolo, M. Tebaldi, E. Olivieri, P. Bonadonna   +9 more
semanticscholar   +1 more source

The Basophil Activation Test Is Not a Useful Screening Tool for Hymenoptera Venom-Related Anaphylaxis in Patients with Systemic Mastocytosis [PDF]

, 2016
Background: Systemic mastocytosis (SM) patients are at a high risk for anaphylaxis, with Hymenoptera as the main culprit. A screening instrument to identify which patients are sensitized to Hymenoptera before they experience anaphylaxis would therefore ...
Daele, P.L.A. (Paul) van, Gerth van Wijk, R. (Roy), Hermans, M.A.W. (Maud A.W.), Rietveld, M.J.A. (Mark J.A.), Schreurs, M.W.J. (Marco)   +4 more
core   +1 more source

An intriguing coexistence of cutaneous and systemic mastocytosis with atypical chronic myeloid leukemia: An associated hematologic neoplasm (SM-AHN)

Journal of Applied Hematology, 2021
Systemic mastocytosis (SM) characterized by focal or diffuse infiltrates of neoplastic mast cells can range from indolent cutaneous disease to aggressive systemic disease.
B R Rajalakshmi, Vijaya Basavaraj
doaj   +1 more source

Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) in a phase 2 clinical study

Orphanet Journal of Rare Diseases, 2021
Background Indolent systemic mastocytosis (ISM) is a rare, clonal mast cell neoplasm characterized by severe, unpredictable symptoms. The Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) items compose a Total Symptom Score (TSS ...
B. Padilla, A. Shields, F. Taylor, Xiaoran Li, J. Mcdonald, T. Green, A. Boral, Hui-Min Lin, C. Akin, F. Siebenhaar, B. Mar   +10 more
semanticscholar   +1 more source

Prolonged IL‐33 Exposure Switches the Secreted Mast Cell Cytokine Profile From Pro‐Inflammatory to Pro‐Tolerant

Allergy, EarlyView.
This study investigates the effect of IL‐33 and Hymenoptera venom on mast cell cytokine profiles under venom immunotherapy (VIT)‐like conditions. Our in vitro model of VIT‐like mast cell stimulation demonstrates a modulatory effect of IL‐33 on the secreted mast cell cytokine profile.
Andrea R. Teufelberger, Carolin Költgen, Magda Babina, Peter Wolf   +3 more
wiley   +1 more source

Regulation of mast cell function and survival in health and disease [PDF]

, 2016
Mast cells are sentinels of danger but they are also the major effector cells in allergic disease causing the well-known allergic symptoms caused by their mediators such as histamine and prostaglandin D2 that are released upon activation. Mastocytosis is
Lyberg, Katarina
core   +1 more source