Results 61 to 70 of about 66,314 (265)

Molecular quantification of tissue disease burden is a new biomarker and independent predictor of survival in mastocytosis

Haematologica, 2020
A high allele burden of the KIT D816V mutation in peripheral blood or bone marrow aspirates indicates multi-lineage hematopoietic involvement and has been associated with an aggressive clinical course of systemic mastocytosis.
Georg Greiner, Michael Gurbisz, Franz Ratzinger, Nadine Witzeneder, Svenja Verena Class, Gregor Eisenwort, Ingrid Simonitsch-Klupp, Harald Esterbauer, Matthias Mayerhofer, Leonhard Müllauer, Wolfgang R. Sperr, Peter Valent, Gregor Hoermann   +12 more
doaj   +1 more source

Comprehensive mastocytosis data analysis from a single center

BMC Cancer, 2023
Mastocytosis is a very rare disorder and is divided into three prognostically distinct variants by World Health Organization: Cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma or localized mast cell (MC) tumors.
Tarık Onur Tiryaki, Sıdıka Gülkan Özkan, Simge Erdem, Aynur Dağlar Aday, İpek Yönal Hindilerden, Aslı Gelincik, Can Baykal, Gülçin Yegen, İbrahim Öner Doğan, Nesimi Büyükbabani, Meliha Nalçacı, Akif Selim Yavuz   +11 more
doaj   +1 more source

French guidelines for the management of nonadvanced mastocytosis in adults

Orphanet Journal of Rare Diseases
Mastocytosis is a rare disease caused by abnormal mast cell accumulation/proliferation in various organs/tissues. Its clinical features exhibit significant variability irrespective of its clinical presentation, classification, global survival or impact ...
Cristina Bulai Livideanu, Stéphane Barete, Ghandi Damaj, Michel Arock, Julien Rossignol, Olivier Hermine   +5 more
doaj   +1 more source

Bullous mastocytosis: a Case Report

Journal of the Egyptian Women’s Dermatologic Society
Mastocytosis is a disorder characterized by abnormal mast cell proliferation. The skin is the most common site of involvement. Extracutaneous involvement occurs in systemic mastocytosis with infiltrations in the gastrointestinal tract, lymph nodes, bone ...
Galal El Enany, Noha Nagui, Hanan Nada, Mona R.E. Abdel-Halim, Iman Sany, Ahmad Nada, Omar El Ghanam, Mona M. Korany   +7 more
doaj   +1 more source

Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report

Case Reports in Medicine, 2010
Mast cell disorders are defined by an abnormal accumulation of tissue mast cells in one or more organ systems. In systemic mastocytosis, at least one extracutaneous organ is involved by definition.
Didem Ozdemir, Selcuk Dagdelen, Tomris Erbas, Kemal Agbaht, Songul Serefhanoglu, Salih Aksu, Sibel Ersoy-Evans   +6 more
doaj   +1 more source

Prolonged IL‐33 Exposure Switches the Secreted Mast Cell Cytokine Profile From Pro‐Inflammatory to Pro‐Tolerant

Allergy, EarlyView.
This study investigates the effect of IL‐33 and Hymenoptera venom on mast cell cytokine profiles under venom immunotherapy (VIT)‐like conditions. Our in vitro model of VIT‐like mast cell stimulation demonstrates a modulatory effect of IL‐33 on the secreted mast cell cytokine profile.
Andrea R. Teufelberger, Carolin Költgen, Magda Babina, Peter Wolf   +3 more
wiley   +1 more source

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway [PDF]

, 2018
Mutations in KIT and TET2 are associated with myeloid malignancies. We show that loss of TET2-induced PI3K activation and -increased proliferation is rescued by targeting the p110α/δ subunits of PI3K.
Gerbaulet, A, Janga, SC, Kapur, R, Mali, RS, Paczesny, S, Palam, LR, Ramdas, B, Roers, A, Srivatsan, SN, Takemoto, CM, Tiu, RV, Vanhaesebroeck, B, Visconte, V, Xu, M   +13 more
core   +1 more source

Diagnosis, management and the burden of symptoms of mastocytosis from the physician's perspective: A nationwide study

British Journal of Haematology, EarlyView.
Summary Mastocytosis is categorized into cutaneous mastocytosis (CM), mast cell sarcoma and systemic mastocytosis (SM). Within SM, indolent SM (ISM) is the more frequent subtype. Adult patients with CM but without an extracutaneous biopsy are classified as having mastocytosis in the skin (MIS), a provisional diagnosis.
Julien Rossignol, Laurence Bouillet, Cristina Bulai‐Livideanu, Stéphane Barete, Julie Bruneau, Clément Gourguechon, Laura Polivka, Angèle Soria, Olivier Lortholary, Trevor Stanbury, Benoit Bouquillon, Cedric Sauvage, Rose Marie Javier, Olivier Hermine, Michel Arock, the CEREMAST Network   +15 more
wiley   +1 more source

An elusive case of systemic mastocytosis [PDF]

Allergy, Asthma & Clinical Immunology, 2010
A 40 year old woman with recurrent “idiopathic” anaphylaxis was referred. Past history revealed a right ovarian mucinous cyst adenoma that was surgically removed. Medications included celebrex and alesse. Six months following the oopherectomy at age 15, she began to experience anaphylaxis every 2 months.
Lee, JK, Vadas, P
openaire   +4 more sources

Assessment of Patients With Beta‐Lactams Positive Provocation Tests by Biomarkers of IgG‐Related Neutrophil Activation

Clinical &Experimental Allergy, EarlyView.
Neutrophil activation in beta‐lactams (BL) immediate hypersensitivity reactions (IHR). Factor component analysis of IHR biomarkers suggests an IgG‐mediated mechanism. We propose Neutrophil Elastase as a biomarker of neutrophil activation in BL IHR. ABSTRACT Background Beta‐lactams (BLs) are the predominant cause of immediate allergic reactions to drugs.
Adrienne Astrid Gallizzi, Rosa‐Maria Guéant‐Rodriguez, Cosmin Boteanu, Jean‐Marc Alberto, Cécile Lakomy, Huguette Louis, Celine Chery, Pauline Renard, Véronique Regnault, Ramia Safar, Almut Heinken, Antonino Romano, Jose‐Julio Laguna, Jean‐Louis Guéant   +13 more
wiley   +1 more source