Results 1 to 10 of about 2,195,068 (238)
European Medical Journal Rheumatology, 2020 Systemic sclerosis (SSc) is a complex autoimmune rheumatic disease that is characterised by widespread skin and internal organ fibrosis, immune system dysregulation, and vasculopathy.
Michael Hughes +3 more
doaj +2 more sources
Epidemiology of systemic sclerosis and systemic sclerosis-associated interstitial lung disease
Clinical Epidemiology, 2019 Aurore Bergamasco,1 Nadine Hartmann,2 Laura Wallace,3 Patrice Verpillat41YolaRx Consultants, Paris, France; 2Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany; 3Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CO, USA ...
Bergamasco A +3 more
doaj +2 more sources
Renal Involvement in Systemic Sclerosis: An Update
Kidney & Blood Pressure Research, 2020 Background: Systemic sclerosis is an immune-mediated rheumatic disease characterized by vascular abnormalities, tissue fibrosis and autoimmune phenomena.
Magdalena Chrabaszcz +6 more
doaj +2 more sources
Systemic sclerosis – multidisciplinary disease: clinical features and treatment
Rheumatology, 2019 Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features.
Piotr Sobolewski +8 more
doaj +2 more sources
Scientific Reports, 2021 Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc
H. Štorkánová +11 more
semanticscholar +1 more source
State-of-the-art evidence in the treatment of systemic sclerosis
Nature Reviews Rheumatology, 2023 Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous SSc (dcSSc) and the use of organ-specific therapies, has improved, as ...
J. Pope +5 more
semanticscholar +1 more source
Diagnostics, 2023 Determination of salivary flow rate and oral status in patients with primary Sjögren’s Syndrome (pSS) and diffuse cutaneous systemic sclerosis (dcSSc) and comparison with control subjects.
Ana Glavina +6 more
doaj +1 more source
Is Th17-Targeted Therapy Effective in Systemic Lupus Erythematosus?
Current Issues in Molecular Biology, 2023 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a broad spectrum of clinical manifestations. The proposed pathophysiological hypotheses of SLE are numerous, involving both innate and adaptive abnormal immune responses.
Marin Petrić, Mislav Radić
doaj +1 more source
Pathophysiology of systemic sclerosis (scleroderma)
Kaohsiung Journal of Medical Sciences, 2022 Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that affects the skin and many other organs. Its pathophysiology is complex and involves an early endothelial damage, an inflammatory infiltrate and a resulting ...
A. Rosendahl, K. Schönborn, T. Krieg
semanticscholar +1 more source
Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
Nature Communications, 2021 Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the modified Rodnan skin score, the most widely used clinical measure of ...
T. Tabib +11 more
semanticscholar +1 more source