Results 11 to 20 of about 314,078 (352)

Systemic sclerosis

The Journal of Dermatology, 2017
AbstractSystemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic and epidemiological studies have demonstrated that SSc onset is determined by the accumulation of predisposing factors related to environmental influences, while genetic ...
Denton, CP, Khanna, D
exaly   +7 more sources

Nintedanib for systemic sclerosis–associated interstitial lung disease [PDF]

New England Journal of Medicine, 2019
BackgroundInterstitial lung disease (ILD) is a common manifestation of systemic sclerosis and a leading cause of systemic sclerosis-related death. Nintedanib, a tyrosine kinase inhibitor, has been shown to have antifibrotic and antiinflammatory effects ...
Alves, Margarida, Azuma, Arata, Clerisme-Beaty, Emmanuelle, Distler, Oliver, Fischer, Aryeh, Gahlemann, Martina, Girard, Mannaig, Highland, Kristin B., Kuwana, Masataka, Maher, Toby M., Mayes, Maureen D., Raghu, Ganesh, Sauter, Wiebke, SENSCIS Trial Investigator, for the, Smith, Vanessa, Stowasser, Susanne, Tetzlaff, Kay   +16 more
core   +5 more sources

Systemic sclerosis and risk of bronchiectasis: a nationwide longitudinal cohort study

Arthritis Research & Therapy, 2023
Background The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare the risk of bronchiectasis between individuals with systemic sclerosis and those without using a nationwide longitudinal ...
Bumhee Yang, Bo-Guen Kim, Kyungdo Han, Jin-Hyung Jung, Ji Hyoun Kim, Dong Won Park, Sang-Heon Kim, Eung-Gook Kim, Jang Won Sohn, Ho Joo Yoon, Hayoung Choi, Hyun Lee   +11 more
doaj   +1 more source

Sine scleroderma, limited cutaneous, and diffused cutaneous systemic sclerosis survival and predictors of mortality

Arthritis Research & Therapy, 2021
Highlights • Male sex, cardiac involvement, DLCO 5 mg/l are strong predictors of mortality in systemic sclerosis. • This study shows the survival of subtypes and in particular sine scleroderma. • Sine scleroderma subtype has better survival than diffuse
Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue, Gregory Pugnet   +13 more
doaj   +1 more source

Living with Systemic Sclerosis: A Patient and Physician Perspective

Rheumatology and Therapy, 2023
The fears associated with being diagnosed with a disease unfamiliar to many, systemic sclerosis, is described by a patient living with systemic sclerosis.
Arissa Young, Brittany Rudy, Elizabeth R Volkmann   +2 more
doaj   +1 more source

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

A Case Report of Systemic Sclerosis Complicated by Biventricular Heart Failure, Pulmonary Hypertension and Review of Literature [PDF]

, 2017
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder whose aetiology is not fully understood. Skin fibrosis and visceral organs involvement are the hallmarks, and the heart could be disproportionately or subtly involved ...
Akinboro AO, Akinlade M, Akintunde AA, Audu MB   +3 more
core   +1 more source

Evaluation of right ventricular function performed by 3d-echocardiography in scleroderma patients [PDF]

, 2015
The impairment of the right ventricle (RV) in systemic sclerosis (SSc) is usually related to pulmonary arterial hypertension (PAH). New echocardiographic techniques, such as 3-dimensional echocardiography (3DE) and 2-dimensional speckle tracking (2DSTE),
Badano, Luigi, Bourji, KHALIL IBRAHIM, Cozzi, Franco, Miatton, P., Peluso, DILETTA MARIA, Pigatto, Erika, Polito, Pamela, Punzi, Leonardo, Zanatta, E.   +8 more
core   +5 more sources

α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis

Life, 2022
Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
Yosuke Kanno, En Shu
doaj   +1 more source

Smoking in Systemic Sclerosis: a Longitudinal European Scleroderma Trials and Research Group Study [PDF]

, 2018
Data on the role of tobacco exposure in systemic sclerosis (SSc) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations in the EUSTAR ...
Airó, Paolo, Alegre-Sancho, Juan J, Allanore, Yannick, Caimmi, Cristian, Carreira, Patricia E, Cozzi, Franco, Czirják, Laszlo, De Langhe, Ellen, Del Galdo, Francesco, Denton, Christopher P, Distler, Oliver, EUSTAR coauthors, Hachulla, Eric, Henes, Jörg, Houssiau, Frédéric, Jaeger, Veronika K, Matucci-Cerinic, Marco, Müller-Ladner, Ulf, Rednic, Simona, Riccieri, Valeria, Rosato, Edoardo, Siegert, Elise, Smith, Vanessa, Ullman, Susanne, Valentini, Gabriele, Walker, Ulrich A   +25 more
core   +5 more sources