Results 11 to 20 of about 1,105,547 (207)

Systemic Sclerosis

open access: yesEuropean Medical Journal Rheumatology, 2020
Systemic sclerosis (SSc) is a complex autoimmune rheumatic disease that is characterised by widespread skin and internal organ fibrosis, immune system dysregulation, and vasculopathy.
Michael Hughes   +3 more
doaj   +1 more source

Sine scleroderma, limited cutaneous, and diffused cutaneous systemic sclerosis survival and predictors of mortality

open access: yesArthritis Research & Therapy, 2021
Highlights • Male sex, cardiac involvement, DLCO 5 mg/l are strong predictors of mortality in systemic sclerosis. • This study shows the survival of subtypes and in particular sine scleroderma. • Sine scleroderma subtype has better survival than diffuse
Sébastien De Almeida Chaves   +13 more
doaj   +1 more source

Systemic sclerosis and risk of bronchiectasis: a nationwide longitudinal cohort study

open access: yesArthritis Research & Therapy, 2023
Background The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare the risk of bronchiectasis between individuals with systemic sclerosis and those without using a nationwide longitudinal ...
Bumhee Yang   +11 more
doaj   +1 more source

Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis. [PDF]

open access: yes, 2015
Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment.
Christopher P Denton   +21 more
core   +1 more source

Living with Systemic Sclerosis: A Patient and Physician Perspective

open access: yesRheumatology and Therapy, 2023
The fears associated with being diagnosed with a disease unfamiliar to many, systemic sclerosis, is described by a patient living with systemic sclerosis.
Arissa Young   +2 more
doaj   +1 more source

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis [PDF]

open access: yes, 2013
Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory ...
Schuerwegh, A. J.   +217 more
core   +1 more source

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis [PDF]

open access: yes, 2011
Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease, with a largely unknown pathogenesis ...
P. Amouyel   +245 more
core   +2 more sources

α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis

open access: yesLife, 2022
Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
Yosuke Kanno, En Shu
doaj   +1 more source

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy [PDF]

open access: yes, 2011
The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc).
Kreuter, A   +618 more
core   +1 more source

Spinal anesthesia for cesarean section in a patient with systemic sclerosis associated interstitial lung disease: a case report [PDF]

open access: yesKorean Journal of Anesthesiology, 2016
Systemic sclerosis or scleroderma is a rare autoimmune disorder characterized by excessive fibrosis and, vasculopathy, with multiorgan involvement. Anesthetic considerations in patients with systemic sclerosis must take into account the degree of organ ...
Guie Yong Lee, Sooyoung Cho
doaj   +1 more source

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