Results 11 to 20 of about 307,381 (359)
Indian Journal of Dental Research, 2007 Systemic sclerosis (scleroderma) is a rare generalized disorder of connective tissue origin. This condition is predominantly a clinical diagnosis, based on the clinical signs and symptoms.
Ahathya R, Deepalakshmi D, Emmadi Pamela
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The Lancet, 2023 Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Once considered an untreatable and unpredictable condition, research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment armamentarium.
Volkmann, Elizabeth R +2 more
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Nature Reviews Disease Primers, 2015 Systemic sclerosis is a complex autoimmune disease characterized by a chronic and frequently progressive course and by extensive patient-to-patient variability. Like other autoimmune diseases, systemic sclerosis occurs more frequently in women, with a peak of onset in the fifth decade of life.
Yannick, Allanore +6 more
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Journal of the American Academy of DermatologyKlasić, Petra, Kezerić, Lorena
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The Journal of Dermatology, 2017 AbstractSystemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic and epidemiological studies have demonstrated that SSc onset is determined by the accumulation of predisposing factors related to environmental influences, while genetic ...
Denton, CP, Khanna, D
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Connective tissue disease-associated pulmonary arterial hypertension. [PDF]
, 2015 Although rare in its idiopathic form, pulmonary arterial hypertension (PAH) is not uncommon in association with various associated medical conditions, most notably connective tissue disease (CTD).
Condliffe, R., Howard, L.S.
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α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis
Life, 2022 Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
Yosuke Kanno, En Shu
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Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension [PDF]
, 2014 Pulmonary arterial hypertension is a major complication of systemic sclerosis. Although oxidative stress, intima hyperplasia and a progressive vessel occlusion appear to be clearly involved, the fine molecular mechanisms underpinning the onset and ...
Boin, Francesco +8 more
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Pathogenesis of Systemic Sclerosis [PDF]
Frontiers in Immunology, 2015 Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities ...
Debendra ePattanaik +5 more
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The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2023 Gastrointestinal dysmotility in systemic sclerosis occurs as the end result of extensive fibrosis of the gastrointestinal tract. The entire length of the tract from the esophagus to the anorectum could be affected, exerting various gastrointestinal ...
Eka Benhardi Layadi +4 more
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