Results 11 to 20 of about 2,195,217 (380)

Systemic sclerosis

The Lancet, 2022
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Once considered an untreatable and unpredictable condition, research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment armamentarium.
E. Volkmann, K. Andréasson, V. Smith
semanticscholar   +5 more sources

Systemic sclerosis

Indian Journal of Dental Research, 2007
Systemic sclerosis (scleroderma) is a rare generalized disorder of connective tissue origin. This condition is predominantly a clinical diagnosis, based on the clinical signs and symptoms.
Ahathya R, Deepalakshmi D, Emmadi Pamela
doaj   +3 more sources

Treatment of systemic sclerosis. [PDF]

Rheumatic Disease Clinics of North America, 1991
Proper classification of patients into diffuse cutaneous and limited cutaneous subsets and the anticipation of complications are the keys to the management of individuals with systemic sclerosis (scleroderma). Patients with early diffuse disease and rapidly progressive skin thickening are at highest risk to develop serious internal organ involvement ...
Thomas A. Medsger
  +15 more sources

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

Tocilizumab Prevents Progression of Early Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis & Rheumatology, 2021
Tocilizumab (TCZ) has demonstrated lung function preservation in 2 randomized controlled trials in early systemic sclerosis (SSc). This effect has yet to be characterized in terms of radiographically evident quantitative lung involvement.
D. Roofeh, Celia J. F. Lin, J. Goldin, G. Kim, D. Furst, C. Denton, Suiyuan Huang, D. Khanna   +7 more
semanticscholar   +1 more source

The burden of systemic sclerosis in Switzerland – the Swiss systemic sclerosis EUSTAR cohort

Swiss Medical Weekly, 2021
OBJECTIVES Characteristics of Swiss patients with systemic sclerosis have not been described so far. The aim of the current study was to identify unmet needs in comparison with other European countries that could inform specific interventions
Jasmin Hernández, Suzana Jordan, Rucsandra Dobrota, Michele Iudici, Paul Hasler, Camillo Ribi, Peter Villiger, Panayiotis Vlachoyiannopoulos, Alessandra Vacca, Ludmila Garzanova, Alessandro Giollo, Edoardo Rosato, Ina Kötter, Patricia E. Carreira, Andrea Doria, Jörg Henes, Ulf Müller-Ladner, Vanessa Smith, Jörg Distler, Armando Gabrielli, Anna-Maria Hoffman-Vold, Ulrich Walker, Oliver Distler, the EUSTAR collaborators   +23 more
doaj   +1 more source

Current Concepts on the Pathogenesis of Systemic Sclerosis

Clinical reviews in allergy and immunology, 2021
From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical presentation and course are highly heterogenous and life expectancy
M. Truchetet, N. Brembilla, C. Chizzolini   +2 more
semanticscholar   +1 more source

French recommendations for the management of systemic sclerosis

Orphanet Journal of Rare Diseases, 2021
Systemic sclerosis (SSc) is a generalized disease of the connective tissue, arterioles, and microvessels, characterized by the appearance of fibrosis and vascular obliteration.
E. Hachulla, C. Agard, Y. Allanore, J. Avouac, B. Bader-Meunier, A. Belot, A. Bérézné, A. Bouthors, G. Condette-Wojtasik, J. Constans, P. De Groote, E. Diot, F. Dumas, P. Jego, F. Joly, D. Launay, V. le Guern, J. Le Quintrec, G. Lescaille, C. Meune, B. Moulin, C. Nguyen, Nadine Omeish, F. Pène, M. Richard, J. Rochefort, A. Roren, O. Sitbon, V. Sobanski, M. Truchetet, L. Mouthon, Marc Emmanuel Sabine Julia Yoram Benjamin Vincent Bruno Bayen Bergot Berthier Bosco Bouhnik Chaigne Cottin, M. Bayen, E. Bergot, S. Berthier, J. Bosco, Y. Bouhnik, B. Chaigne, V. Cottin, B. Crestani, C. Deligny, V. Descroix, D. Farge, D. Godard, B. Granel, P. Guilpain, B. Imbert, A. le Quellec, C. Lega, C. Lok, H. Maillard, T. Martin, G. Pugnet, V. Queyrel, L. Raffray, F. Rilliard, M. Romier, Lauren Schuller, A. Servettaz   +58 more
semanticscholar   +1 more source

Pathogenesis of Systemic Sclerosis [PDF]

Frontiers in Immunology, 2015
Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities ...
Debendra ePattanaik, Debendra ePattanaik, Monica eBrown, Bradley C. Postlethwaite, Arnold E Postlethwaite, Arnold E Postlethwaite   +5 more
openaire   +4 more sources

Sine scleroderma, limited cutaneous, and diffused cutaneous systemic sclerosis survival and predictors of mortality

Arthritis Research & Therapy, 2021
Highlights • Male sex, cardiac involvement, DLCO 5 mg/l are strong predictors of mortality in systemic sclerosis. • This study shows the survival of subtypes and in particular sine scleroderma. • Sine scleroderma subtype has better survival than diffuse
Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue, Gregory Pugnet   +13 more
doaj   +1 more source