Results 21 to 30 of about 1,674,118 (394)

Sine scleroderma, limited cutaneous, and diffused cutaneous systemic sclerosis survival and predictors of mortality

Arthritis Research & Therapy, 2021
Highlights • Male sex, cardiac involvement, DLCO 5 mg/l are strong predictors of mortality in systemic sclerosis. • This study shows the survival of subtypes and in particular sine scleroderma. • Sine scleroderma subtype has better survival than diffuse
Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue, Gregory Pugnet   +13 more
doaj   +1 more source

Systemic sclerosis

The Lancet, 2017
Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy. Although systemic sclerosis is uncommon, it has a high morbidity and mortality. Improved understanding of systemic sclerosis has allowed better management of the disease, including ...
Denton, CP, Khanna, D
openaire   +5 more sources

Systemic sclerosis and risk of bronchiectasis: a nationwide longitudinal cohort study

Arthritis Research & Therapy, 2023
Background The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare the risk of bronchiectasis between individuals with systemic sclerosis and those without using a nationwide longitudinal ...
Bumhee Yang, Bo-Guen Kim, Kyungdo Han, Jin-Hyung Jung, Ji Hyoun Kim, Dong Won Park, Sang-Heon Kim, Eung-Gook Kim, Jang Won Sohn, Ho Joo Yoon, Hayoung Choi, Hyun Lee   +11 more
doaj   +1 more source

Living with Systemic Sclerosis: A Patient and Physician Perspective

Rheumatology and Therapy, 2023
The fears associated with being diagnosed with a disease unfamiliar to many, systemic sclerosis, is described by a patient living with systemic sclerosis.
Arissa Young, Brittany Rudy, Elizabeth R Volkmann   +2 more
doaj   +1 more source

French recommendations for the management of systemic sclerosis

Orphanet Journal of Rare Diseases, 2021
Systemic sclerosis (SSc) is a generalized disease of the connective tissue, arterioles, and microvessels, characterized by the appearance of fibrosis and vascular obliteration.
E. Hachulla, C. Agard, Y. Allanore, J. Avouac, B. Bader-Meunier, A. Belot, A. Bérézné, A. Bouthors, G. Condette-Wojtasik, J. Constans, P. De Groote, E. Diot, F. Dumas, P. Jego, F. Joly, D. Launay, V. le Guern, J. Le Quintrec, G. Lescaille, C. Meune, B. Moulin, C. Nguyen, Nadine Omeish, F. Pène, M. Richard, J. Rochefort, A. Roren, O. Sitbon, V. Sobanski, M. Truchetet, L. Mouthon, Marc Emmanuel Sabine Julia Yoram Benjamin Vincent Bruno Bayen Bergot Berthier Bosco Bouhnik Chaigne Cottin, M. Bayen, E. Bergot, S. Berthier, J. Bosco, Y. Bouhnik, B. Chaigne, V. Cottin, B. Crestani, C. Deligny, V. Descroix, D. Farge, D. Godard, B. Granel, P. Guilpain, B. Imbert, A. le Quellec, C. Lega, C. Lok, H. Maillard, T. Martin, G. Pugnet, V. Queyrel, L. Raffray, F. Rilliard, M. Romier, Lauren Schuller, A. Servettaz   +58 more
semanticscholar   +1 more source

Systemic sclerosis

British Journal of Hospital Medicine, 2019
Systemic sclerosis is a complex autoimmune connective tissue disease which carries a significant burden of disease-related morbidity including potentially life-threatening complications. Systemic sclerosis can affect all the major organs and therefore, although the disease is uncommon, many hospital-based specialists are involved in patient care ...
Hughes, Michael, Herrick, Ariane L
openaire   +7 more sources

Pulmonary hypertension phenotypes in patients with systemic sclerosis

European Respiratory Review, 2021
Pulmonary hypertension (PH) commonly affects patients with systemic sclerosis (SSc) and is associated with significant morbidity and increased mortality.
A. Haque, D. Kiely, G. Kovacs, A. Thompson, R. Condliffe   +4 more
semanticscholar   +1 more source

Pathogenesis of Systemic Sclerosis [PDF]

Frontiers in Immunology, 2015
Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities ...
Debendra ePattanaik, Debendra ePattanaik, Monica eBrown, Bradley C. Postlethwaite, Arnold E Postlethwaite, Arnold E Postlethwaite   +5 more
openaire   +4 more sources

Expansion of Fcγ Receptor IIIa–Positive Macrophages, Ficolin 1–Positive Monocyte‐Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis

Arthritis & Rheumatology, 2021
In this study, we sought a comprehensive understanding of myeloid cell types driving fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) skin.
D. Xue, T. Tabib, C. Morse, Yi Yang, R. Domsic, D. Khanna, R. Lafyatis   +6 more
semanticscholar   +1 more source

α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis

Life, 2022
Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
Yosuke Kanno, En Shu
doaj   +1 more source