Results 31 to 40 of about 2,202,845 (238)

Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis

Arthritis & Rheumatology, 2020
Expression of dipeptidylpeptidase 4 (DPP‐4) identifies a dermal fibroblast lineage involved in scarring during wound healing. The role of DDP‐4 in tissue fibrosis is, however, unknown.
A. Soare, Hermina A. Györfi, A. Matei, C. Dees, S. Rauber, T. Wohlfahrt, Chih-Wei Chen, I. Ludolph, R. Horch, T. Bäuerle, S. Hörsten, C. Mihai, O. Distler, A. Ramming, G. Schett, J. Distler   +15 more
semanticscholar   +1 more source

Depression in systemic sclerosis: Review of the neuro-immunologic link and pharmacological management

Medical Journal of Dr. D.Y. Patil University, 2016
Depression is a common neuropsychiatric condition associated with systemic sclerosis. The association of depression and systemic sclerosis is the result of multiple mechanisms such as autoimmune, significant morbidity due to multi-system involvement ...
Aditya Somani, Sujita Kumar Kar, Jyoti Ranjan Parida   +2 more
doaj   +1 more source

Case report of systemic sclerosis: Uncommon manifestation of nephrotic syndrome post-renal crisis

SAGE Open Medical Case Reports, 2023
Kidney involvement in systemic sclerosis occurs in about 20% of cases, with scleroderma renal crisis as a significant complication. However, cases of glomerular disease with massive proteinuria are rare.
Ai Fujii, Takaya Kondo, Yasutaka Katsura, Sho Kumano, Serina Kita, Kazutoshi Nomura, Tomohisa Yabe, Norifumi Hayashi, Keiji Fujimoto, Hitoshi Yokoyama, Kengo Furuichi   +10 more
doaj   +1 more source

Safety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo‐Controlled Trial in Adults With Systemic Sclerosis

Arthritis & Rheumatology, 2020
To assess the safety and efficacy of lenabasum in diffuse cutaneous systemic sclerosis (dcSSc).
R. Spiera, L. Hummers, L. Chung, T. Frech, R. Domsic, V. Hsu, D. Furst, J. Gordon, M. Mayes, R. Simms, R. Lafyatis, V. Martyanov, Tammara A. Wood, M. Whitfield, S. Constantine, Elizabeth Lee, N. Dgetluck, B. White   +17 more
semanticscholar   +1 more source

A chemotaxis reaction-diffusion model for Multiple Sclerosis with Allee effect [PDF]

arXiv, 2023
In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75, 373--417]. In particular, we hypothesize a minimal amount of macrophages to be able to start and sustain the inflammatory ...
arxiv  

Autologous stem cell transplantation for progressive systemic sclerosis: a prospective non-interventional study from the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party

Haematologica, 2020
Three randomized controlled trials in early severe systemic sclerosis demonstrated that autologous hematopoietic stem cell transplantation was superior to standard cyclophosphamide therapy.
J. Henes, M. Oliveira, M. Labopin, M. Badoglio, H. Scherer, N. Del Papa, T. Daikeler, M. Schmalzing, R. Schroers, T. Martin, G. Pugnet, B. Simões, D. Michonneau, E. Marijt, B. Lioure, J. Bay, J. Snowden, M. Rovira, A. Huynh, F. Onida, L. Kanz, Z. Marjanovic, D. Farge   +22 more
semanticscholar   +1 more source

On a chemotaxis model with nonlinear diffusion modelling multiple sclerosis [PDF]

arXiv, 2023
We investigated existence of global weak solutions for a system of chemotaxis type with nonlinear degenerate diffusion, arising in modelling Multiple Sclerosis disease. The model consists of three equations describing the evolution of macrophages ($m$), cytokine ($c$) and apoptotic oligodendrocytes ($d$). The main novelty in our work is the presence of
arxiv  

Osteopetrosis in a Patient of Systemic Sclerosis Sine Scleroderma: A Rare Association

Indian Journal of Radiology and Imaging, 2021
Systemic sclerosis is a connective tissue disorder of unknown etiology. Although it is a multisystemic disorder, skin thickening is considered as a hallmark of the disease.
Saroj K. Pati, Praveen Raja, Ajoy K. Behera, T.G. Ranganath, Narendra K. Bodhey   +4 more
doaj   +1 more source

Pathogenesis of systemic sclerosis associated interstitial lung disease

Journal of Scleroderma and Related Disorders, 2020
Systemic sclerosis is an autoimmune disease leading to vasculopathy and fibrosis of skin and internal organs. Despite likely shared pathogenic mechanisms, the patterns of skin and lung fibrosis differ.
S. Nihtyanova, C. Denton
semanticscholar   +1 more source

Single cell analysis in systemic sclerosis – A systematic review

Immunological Medicine
In recent years, rapid advances in research methods have made single cell analysis possible. Systemic sclerosis (SSc), a disease characterized by the triad of immune abnormalities, fibrosis, and vasculopathy, has also been the subject of various analyses.
Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Atsushi Enomoto, Takashi Yamashita, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki   +6 more
doaj   +1 more source