Results 31 to 40 of about 2,211,371 (282)

Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator‐Initiated, Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Trial

open access: yesArthritis & Rheumatology, 2020
T cells play a key role in the pathogenesis of early systemic sclerosis. This study was undertaken to assess the safety and efficacy of abatacept in patients with diffuse cutaneous systemic sclerosis (dcSSc).
D. Khanna   +38 more
semanticscholar   +1 more source

The immunopathology of systemic sclerosis [PDF]

open access: yesSeminars in Immunopathology, 2015
This article is a contribution to the Special Issue on Immunopathology of systemic sclerosis – Guest Editors: Jacob M.
van Laar, Jacob M., Varga, John
openaire   +4 more sources

Spinal anesthesia for cesarean section in a patient with systemic sclerosis associated interstitial lung disease: a case report [PDF]

open access: yesKorean Journal of Anesthesiology, 2016
Systemic sclerosis or scleroderma is a rare autoimmune disorder characterized by excessive fibrosis and, vasculopathy, with multiorgan involvement. Anesthetic considerations in patients with systemic sclerosis must take into account the degree of organ ...
Guie Yong Lee, Sooyoung Cho
doaj   +1 more source

Systemic Sclerosis and Cancer [PDF]

open access: yesInternational Journal of Immunopathology and Pharmacology, 2009
To review recent advances and current controversies on the association between systemic sclerosis (SSc) and cancer, PUBMED was searched from 1966 to the present using the terms: systemic sclerosis, cancer, morphoea, sclerotic diseases. Malignancies, mainly in lung and breast, coexist with idiopathic SSc or with SSc-like disorders, but not with ...
Laura Belloli   +3 more
openaire   +4 more sources

The prevalence of median neuropathy at wrist in systemic sclerosis patients at Srinagarind Hospital

open access: yesJournal of the Scientific Society, 2015
Objectives: To determine the prevalence and factor related with median neuropathy at wrist (MNW) in systemic sclerosis patients. Study Design: Cross-sectional study. Setting: Srinagarind Hospital, Khon Kaen, Thailand.
Thanaporn Nimitbancha   +3 more
doaj   +1 more source

Case report of systemic sclerosis: Uncommon manifestation of nephrotic syndrome post-renal crisis

open access: yesSAGE Open Medical Case Reports, 2023
Kidney involvement in systemic sclerosis occurs in about 20% of cases, with scleroderma renal crisis as a significant complication. However, cases of glomerular disease with massive proteinuria are rare.
Ai Fujii   +10 more
doaj   +1 more source

Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis.

open access: yesJournal of Clinical Investigation, 2020
Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of thirty-five untreated patients with early diffuse ...
T. Maehara   +15 more
semanticscholar   +1 more source

Quantification of mitochondrial DNA damage and copy number in circulating blood of patients with systemic sclerosis by a qPCR-based assay, [PDF]

open access: yesAnais Brasileiros de Dermatologia, 2020
Background: Although not fully understood, oxidative stress has been implicated in the pathogenesis of different autoimmune diseases such as systemic sclerosis.
Shafieh Movassaghi   +5 more
doaj   +1 more source

Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis

open access: yesArthritis & Rheumatology, 2020
Expression of dipeptidylpeptidase 4 (DPP‐4) identifies a dermal fibroblast lineage involved in scarring during wound healing. The role of DDP‐4 in tissue fibrosis is, however, unknown.
A. Soare   +15 more
semanticscholar   +1 more source

Depression in systemic sclerosis: Review of the neuro-immunologic link and pharmacological management

open access: yesMedical Journal of Dr. D.Y. Patil University, 2016
Depression is a common neuropsychiatric condition associated with systemic sclerosis. The association of depression and systemic sclerosis is the result of multiple mechanisms such as autoimmune, significant morbidity due to multi-system involvement ...
Aditya Somani   +2 more
doaj   +1 more source

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