Results 1 to 10 of about 26,012,510 (346)

Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT [PDF]

Cancer Informatics, 2007
Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are of critical importance for cancer
Sean Martin, Le Zhang, Thomas S. Deisboeck   +2 more
doaj   +2 more sources

Software that goes with the flow in systems biology [PDF]

, 2010
A recent article in BMC Bioinformatics describes new advances in workflow systems for computational modeling in systems biology. Such systems can accelerate, and improve the consistency of, modeling through automation not only at the simulation and ...
Michael Hucka, Nicolas Le Novère
openalex   +6 more sources

Systems biology in animal sciences [PDF]

, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
H. Woelders, M.F.W. te Pas, A. Bannink, R.F. Veerkamp, M.A. Smits   +4 more
openalex   +5 more sources

Systems immunology: When systems biology meets immunology [PDF]

Frontiers in Immunology
The immune system is an intricate network of cells, proteins, and signaling pathways that coordinate protective responses and, when dysregulated, drive immune−related diseases.
Lucía Alfonso-González, Lucía Alfonso-González, Francisco J. Fernández, M. Cristina Vega   +3 more
doaj   +2 more sources

Computational Systems Biology [PDF]

The Scientific World Journal, 2013
Xing-Ming Zhao, Weidong Tian, Rui Jiang, Jun Wan   +3 more
doaj   +2 more sources

Systems biology for biologists. [PDF]

PLoS Pathogens, 2015
Rachel A Hillmer
doaj   +3 more sources

PEtab—Interoperable specification of parameter estimation problems in systems biology [PDF]

PLoS Comput. Biol., 2020
Reproducibility and reusability of the results of data-based modeling studies are essential. Yet, there has been—so far—no broadly supported format for the specification of parameter estimation problems in systems biology.
Leonard Schmiester, Yannik Schalte, Frank T. Bergmann, Tacio Camba, E. Dudkin, Janine Egert, F. Frohlich, L. Fuhrmann, Adrian L Hauber, S. Kemmer, Polina Lakrisenko, Carolin Loos, Simon Merkt, Dilan Pathirana, Elba Raim'undez, Lukas Refisch, Marcus Rosenblatt, P. Stapor, P. Stadter, Dantong Wang, Franz-Georg Wieland, J. Banga, J. Timmer, A. F. Villaverde, S. Sahle, C. Kreutz, J. Hasenauer, Daniel Weindl Institute of Computational Biology, H. Z. M. -. G. R. C. F. E. Health, Center for Mathematics, T. U. Munchen, BioQUANTCOS, H. University, D. O. Mathematics, U. Vigo, BioProcess Engineering Group, IIM-CSIC, Faculty of Mathematics, Natural Sciences, U. Bonn, Faculty of Veterinary Medicine, Medical Center, Institute of Medical Biometry, Statistics, F. -. F. C. F. D. Analysis, Modeling, U. Freiburg, Department of Medical Biology, H. School, Institute of Radiation Physics, Ragon Institute of Mgh, Mit, Harvard, Cambridge, Department of Microsystems Engineering, M. I. O. Technology, Signalling Research Centres Bioss, Cibss   +57 more
semanticscholar   +1 more source

Systems biology for crop improvement

The Plant Genome, 2021
In recent years, generation of large‐scale data from genome, transcriptome, proteome, metabolome, epigenome, and others, has become routine in several plant species.
Lekha T Pazhamala, H. Kudapa, W. Weckwerth, A. Harvey Millar, R. Varshney   +4 more
semanticscholar   +1 more source

Pioneer factors in development and cancer

iScience, 2021
Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
doaj   +1 more source

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling

iScience, 2021
Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha, Inês Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M. Gilkes, Paul Macklin   +7 more
doaj   +1 more source