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Frontiers in Genetics, 2015 The marine environment accounts for an important part of the earth biodiversity, featuring several types of (even extreme) ecosystems, and is at the origin of life. Marine prokaryotic and eukaryotic organisms are very diverse, and are sometimes, in particular for the latter, the result of intricate evolutionary history. This biodiversity, encounters in
Thierry eTonon, Damien eEveillard
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Frontiers in Plant Science, 2014 The understanding of biological complexity has been greatly facilitated by cross-disciplinary, holistic approaches that allow insights into the function and regulation of biological processes that cannot be captured by dissecting them into their individual components. In addition, the development of novel tools has dramatically increased our ability to
Wolfgang eSchmidt
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Computational Systems Biology [PDF]
The Scientific World Journal, 2013 The complex biological systems consist of distinct molecules that exert their functions by interacting with each other, which makes it a big challenge to understand how the cellular machinery works. Recently, the accumulation of a large amount of multiscale omics data, such as next-generation sequencing data and protein interaction data, provides ...
Xing-Ming Zhao +3 more
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Systems immunology: When systems biology meets immunology [PDF]
Frontiers in ImmunologyThe immune system is an intricate network of cells, proteins, and signaling pathways that coordinate protective responses and, when dysregulated, drive immune−related diseases.
Lucía Alfonso-González +3 more
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Systems engineering to systems biology
Molecular Systems Biology, 2008 Mol Syst Biol. 4: 185 The ‘bottom‐up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top‐down’ fashion, using a variety of network reverse engineering methods, data‐driven modeling and
Muhammed A Yıldırım, Marc Vidal
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Journal of The Royal Society Interface, 2017 Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades.
Avi Ma’ayan
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Systems biology for crop improvement
The Plant Genome, 2021 In recent years, generation of large‐scale data from genome, transcriptome, proteome, metabolome, epigenome, and others, has become routine in several plant species.
Lekha T Pazhamala +4 more
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PEtab—Interoperable specification of parameter estimation problems in systems biology [PDF]
PLoS Comput. Biol., 2020 Reproducibility and reusability of the results of data-based modeling studies are essential. Yet, there has been—so far—no broadly supported format for the specification of parameter estimation problems in systems biology.
Leonard Schmiester +57 more
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Pioneer factors in development and cancer
iScience, 2021 Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
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