Results 1 to 10 of about 2,995,224 (299)
iScience, 2022 Summary: Autoimmune diseases (ADs) are at a significantly higher risk of cancers with unclear mechanism. By searching GWAS catalog database and Medline, susceptible genes for five common ADs, including systemic lupus erythematosus (SLE), rheumatoid ...
Shasha Li +10 more
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A metabolic regulatory network for the Caenorhabditis elegans intestine
iScience, 2022 Summary: Metabolic perturbations can affect gene expression, for instance to rewire metabolism. While numerous efforts have measured gene expression in response to individual metabolic perturbations, methods that determine all metabolic perturbations ...
Sushila Bhattacharya +7 more
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iScience, 2021 Summary: Whether arterial-venous differences of primary endothelial cells commonly used for vascular research are preserved in vitro remains under debate.
Fabian Vega-Tapia +2 more
doaj +1 more source
iScience, 2021 Summary: Base editing (BE) is a promising genome engineering tool for modifying DNA or RNA and has been widely used in various microorganisms as well as eukaryotic cells.
Tianyuan Su +6 more
doaj +1 more source
A yeast chemogenomic screen identifies pathways that modulate adipic acid toxicity
iScience, 2021 Summary: Adipic acid production by yeast fermentation is gaining attention as a renewable source of platform chemicals for making nylon products. However, adipic acid toxicity inhibits yeast growth and fermentation.
Eugene Fletcher +3 more
doaj +1 more source
STAR Protocols, 2023 Summary: RNA-binding proteins (RBPs) can bind and mediate RNA-RNA contacts. However, identifying specific RBP-organized RNA-RNA contacts remains challenging.
Rong Ye, Naijing Hu, Yuanchao Xue
doaj +1 more source
Systems biology in animal sciences [PDF]
, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A. +4 more
core +3 more sources
Metabolomic systems biology of trypanosomes [PDF]
, 2010 Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
BARBARA M. BAKKER +4 more
core +7 more sources
Computational inference in systems biology [PDF]
, 2015 Parameter inference in mathematical models of biological pathways, expressed as coupled ordinary differential equations (ODEs), is a challenging problem. The computational costs associated with repeatedly solving the ODEs are often high.
A. Lotka +9 more
core +1 more source
Systems biology and cancer, [Editorial] [PDF]
, 2011 The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome,
Maini, Philip +3 more
core +2 more sources