Results 1 to 10 of about 46,168 (99)

Systems Biology in Periodontitis

open access: yesFrontiers in Dental Medicine, 2022
Systems biology is a promising scientific discipline that allows an integrated investigation of host factors, microbial composition, biomarkers, immune response and inflammatory mediators in many conditions such as chronic diseases, cancer, neurological ...
Davi Neto de Araújo Silva   +2 more
doaj   +1 more source

An oscillating reaction network with an exact closed form solution in the time domain

open access: yesBMC Bioinformatics, 2023
Background Oscillatory behavior is critical to many life sustaining processes such as cell cycles, circadian rhythms, and notch signaling. Important biological functions depend on the characteristics of these oscillations (hereafter, oscillation ...
Joseph Hellerstein
doaj   +1 more source

Pioneer factors in development and cancer

open access: yesiScience, 2021
Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
doaj  

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling

open access: yesiScience, 2021
Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha   +7 more
doaj  

A network approach reveals driver genes associated with survival of patients with triple-negative breast cancer

open access: yesiScience, 2021
Summary: We aimed to identify triple-negative breast cancer (TNBC) drivers that regulate survival time as predictive signatures that improve TNBC prognostication.
Courtney D. Dill   +4 more
doaj  

Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers

open access: yesiScience, 2022
Summary: Autoimmune diseases (ADs) are at a significantly higher risk of cancers with unclear mechanism. By searching GWAS catalog database and Medline, susceptible genes for five common ADs, including systemic lupus erythematosus (SLE), rheumatoid ...
Shasha Li   +10 more
doaj  

A metabolic regulatory network for the Caenorhabditis elegans intestine

open access: yesiScience, 2022
Summary: Metabolic perturbations can affect gene expression, for instance to rewire metabolism. While numerous efforts have measured gene expression in response to individual metabolic perturbations, methods that determine all metabolic perturbations ...
Sushila Bhattacharya   +7 more
doaj  

Design considerations for representing systems biology information with the Systems Biology Graphical Notation

open access: yesJournal of Integrative Bioinformatics, 2022
Visual representations are commonly used to explore, analyse, and communicate information and knowledge in systems biology and beyond. Such visualisations not only need to be accurate but should also be aesthetically pleasing and informative.
Schreiber Falk, Czauderna Tobias
doaj   +1 more source

Base editing-coupled survival screening enabled high-sensitive analysis of PAM compatibility and finding of the new possible off-target

open access: yesiScience, 2021
Summary: Base editing (BE) is a promising genome engineering tool for modifying DNA or RNA and has been widely used in various microorganisms as well as eukaryotic cells.
Tianyuan Su   +6 more
doaj  

A yeast chemogenomic screen identifies pathways that modulate adipic acid toxicity

open access: yesiScience, 2021
Summary: Adipic acid production by yeast fermentation is gaining attention as a renewable source of platform chemicals for making nylon products. However, adipic acid toxicity inhibits yeast growth and fermentation.
Eugene Fletcher   +3 more
doaj  

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