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Frontiers in Genetics, 2015 The marine environment accounts for an important part of the earth biodiversity, featuring several types of (even extreme) ecosystems, and is at the origin of life. Marine prokaryotic and eukaryotic organisms are very diverse, and are sometimes, in particular for the latter, the result of intricate evolutionary history. This biodiversity, encounters in
Thierry eTonon, Damien eEveillard
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Frontiers in Plant Science, 2014 The understanding of biological complexity has been greatly facilitated by cross-disciplinary, holistic approaches that allow insights into the function and regulation of biological processes that cannot be captured by dissecting them into their individual components. In addition, the development of novel tools has dramatically increased our ability to
Wolfgang eSchmidt
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Systems engineering to systems biology
Molecular Systems Biology, 2008 Mol Syst Biol. 4: 185 The ‘bottom‐up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top‐down’ fashion, using a variety of network reverse engineering methods, data‐driven modeling and
Muhammed A Yıldırım, Marc Vidal
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AutoAnalyze in Systems Biology [PDF]
Bioinformatics and Biology Insights, 2019 AutoAnalyze is a highly customizable framework for the visualization and analysis of large-scale model graphs. Originally developed for use in the automotive domain, it also supports efficient computation within molecular networks represented by reaction
Christian Saad +3 more
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Systems immunology: When systems biology meets immunology [PDF]
Frontiers in ImmunologyThe immune system is an intricate network of cells, proteins, and signaling pathways that coordinate protective responses and, when dysregulated, drive immune−related diseases.
Lucía Alfonso-González +3 more
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Systems biology reveals biology of systems [PDF]
Complexity, 2010 AbstractIn the last decades, genomic and postgenomic technologies obtained a great amount of information on molecular bases of cell physiology and organization. In spite of this, the knowledge of cells and living organisms in their entirety, is far from being achieved.
Marta Bertolaso +2 more
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Systems biology at the Institute for Systems Biology [PDF]
Briefings in Functional Genomics and Proteomics, 2008 Systems biology represents an experimental approach to biology that attempts to study biological systems in a holistic rather than an atomistic manner. Ideally this involves gathering dynamic and global data sets as well as phenotypic data from different levels of the biological information hierarchy, integrating them and modeling them graphically and ...
Leroy, Hood +3 more
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Pioneer factors in development and cancer
iScience, 2021 Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
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iScience, 2021 Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha +7 more
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