Results 91 to 100 of about 25,508,313 (370)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

EcoCyc: fusing model organism databases with systems biology. [PDF]

, 2012
EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E.
Bonavides-Martínez, César, Collado-Vides, Julio, Fulcher, Carol, Gama-Castro, Socorro, Gunsalus, Robert P, Huerta, Araceli M, Karp, Peter D, Keseler, Ingrid M, Kothari, Anamika, Krummenacker, Markus, Latendresse, Mario, Mackie, Amanda, Muñiz-Rascado, Luis, Ong, Quang, Paley, Suzanne, Paulsen, Ian, Peralta-Gil, Martin, Santos-Zavaleta, Alberto, Schröder, Imke, Shearer, Alexander G, Subhraveti, Pallavi, Travers, Mike, Weerasinghe, Deepika, Weiss, Verena   +23 more
core   +1 more source

Systems Biology of Metabolism.

Annual Review of Biochemistry, 2017
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology.
J. Nielsen
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Yeast Systems Biology [PDF]

FEMS Yeast Research, 2008
Systems Biology (SB) is a rapidly developing field, which is expected to have a major impact on the future of biological and medical research. It aims at system-level understanding of biological processes employing mathematical analysis and computational tools to integrate the information content obtained in experimental biology.
Merja Penttilä, Jens Nielsen, Teun Boekhout   +2 more
openaire   +3 more sources

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT [PDF]

, 2016
Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the intrinsic complexity of pathway ...
Boiko, Andrei, Bown, James L., Goltsov, Alexey, Harrison, David J., Mullen, Peter, Robertson, Paul, Shovman, Mark   +6 more
core   +3 more sources

Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach

npj Systems Biology and Applications, 2017
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and ...
O. Iborra-Egea, C. Gálvez-Montón, S. Roura, I. Perea-Gil, C. Prat-Vidal, C. Soler-Botija, A. Bayés‐Genís   +6 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Small RNA biology is systems biology

BMB Reports, 2011
During the last decade small regulatory RNA (srRNA) emerged as central players in the regulation of gene expression in all kingdoms of life. Multiple pathways for srRNA biogenesis and diverse mechanisms of gene regulation may indicate that srRNA regulation evolved independently multiple times.
Jost, Daniel, Nowojewski, Andrzej, Levine, Erel   +2 more
openaire   +5 more sources

Advances on plant–pathogen interactions from molecular toward systems biology perspectives

The Plant Journal, 2017
Summary In the past 2 decades, progress in molecular analyses of the plant immune system has revealed key elements of a complex response network. Current paradigms depict the interaction of pathogen‐secreted molecules with host target molecules leading ...
Rémi Peyraud, Ullrich Dubiella, Adelin Barbacci, S. Genin, S. Raffaele, D. Roby   +5 more
semanticscholar   +1 more source