Results 31 to 40 of about 1,188,505 (261)
SYSTEMS BIOLOGY. Systems biology (un)certainties.
Science (New York, N.Y.), 2015 How can modelers restore confidence in systems and computational biology? Systems biology, some have claimed ( 1 ), attempts the impossible and is doomed to fail. Possible definitions abound, but systems biology is widely understood to be an approach for studying the behavior of systems of interacting biological components that combines experiments ...
Kirk, PDW, Babtie, AC, Stumpf, MPH
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IET Systems Biology, 2011 Advances in systems biology are increasingly dependent upon the integration of various types of data and different methodologies to reconstruct how cells work at the systemic level. Thus, teams with a varied array of expertise and people with interdisciplinary training are needed.
R, Alves, E, Vilaprinyo, A, Sorribas
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An oscillating reaction network with an exact closed form solution in the time domain
BMC Bioinformatics, 2023 Background Oscillatory behavior is critical to many life sustaining processes such as cell cycles, circadian rhythms, and notch signaling. Important biological functions depend on the characteristics of these oscillations (hereafter, oscillation ...
Joseph Hellerstein
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iScience, 2021 Summary: Recent findings indicate that changes underlying cancer onset and progression are not only attributable to changes in DNA structure and expression of individual genes but to changes in interactions among these genes as well.
Zainab Arshad, John F. McDonald
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Journal of The Royal Society Interface, 2017 Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades.
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Systems biology at the Institute for Systems Biology [PDF]
Briefings in Functional Genomics and Proteomics, 2008 Systems biology represents an experimental approach to biology that attempts to study biological systems in a holistic rather than an atomistic manner. Ideally this involves gathering dynamic and global data sets as well as phenotypic data from different levels of the biological information hierarchy, integrating them and modeling them graphically and ...
Leroy, Hood +3 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij +11 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
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Development of OX40 agonists for canine cancer immunotherapy
iScience, 2022 Summary: Recent breakthroughs in cancer immunotherapy have provided unprecedented clinical benefits to human cancer patients. Cancer is also one of the most common causes of death in pet dogs.
Damien Ruiz +10 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda +15 more
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