Results 31 to 40 of about 25,508,313 (370)
Systems Biology in Periodontitis
Frontiers in Dental Medicine, 2022 Systems biology is a promising scientific discipline that allows an integrated investigation of host factors, microbial composition, biomarkers, immune response and inflammatory mediators in many conditions such as chronic diseases, cancer, neurological ...
Davi Neto de Araújo Silva +2 more
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An oscillating reaction network with an exact closed form solution in the time domain
BMC Bioinformatics, 2023 Background Oscillatory behavior is critical to many life sustaining processes such as cell cycles, circadian rhythms, and notch signaling. Important biological functions depend on the characteristics of these oscillations (hereafter, oscillation ...
Joseph Hellerstein
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SBML models and MathSBML [PDF]
, 2008 MathSBML is an open-source, freely-downloadable Mathematica package that facilitates working with Systems Biology Markup Language (SBML) models. SBML is a toolneutral,computer-readable format for representing models of biochemical reaction networks ...
Shapiro, B.E. +9 more
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Pioneer factors in development and cancer
iScience, 2021 Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
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Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community
Metabolites, 2019 The use of multiple omics techniques (i.e., genomics, transcriptomics, proteomics, and metabolomics) is becoming increasingly popular in all facets of life science.
F. Pinu +6 more
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iScience, 2021 Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha +7 more
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Systems biology informed deep learning for inferring parameters and hidden dynamics
bioRxiv, 2019 Mathematical models of biological reactions at the system-level lead to a set of ordinary differential equations with many unknown parameters that need to be inferred using relatively few experimental measurements.
A. Yazdani +3 more
semanticscholar +1 more source
Molecular Systems Biology, 2006 Genome-scale networks can now be reconstructed based on high-throughput data sets. Mathematical analyses of these networks are used to compute their candidate functional or phenotypic states. Analysis of functional states of networks shows that the activity of biochemical reactions can be highly correlated in physiological states, forming so-called co ...
Jamshidi, Neema, Palsson, Bernhard Ø
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Yeast Systems Biology: Model Organism and Cell Factory
Biotechnology Journal, 2019 For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a cell factory for the production of bread, beer, and wine. In more recent years, this yeast has also served as a cell factory for producing many different fuels ...
J. Nielsen
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Imaging in Systems Biology [PDF]
Cell, 2007 Most systems biology approaches involve determining the structure of biological circuits using genomewide "-omic" analyses. Yet imaging offers the unique advantage of watching biological circuits function over time at single-cell resolution in the intact animal.
Megason, Sean G., Fraser, Scott E.
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