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Enhanced Operational Semantics in Systems Biology [PDF]
We are faced with a great challenge: the cross-fertilization between the fields of formal methods for concurrency, in the computer science domain, and systems biology in the biological ...
A. Dovier+11 more
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Systems Biology, Integrative Biology, Predictive Biology [PDF]
The pursuit of science is based on empiricism enabled by advancing technologies. Theories then emerge that unify our understanding of natural order. The trinity of experimentation, theory, and technology that underlies the scientific method cannot be placed into a hierarchy of importance.
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Genome-scale networks can now be reconstructed based on high-throughput data sets. Mathematical analyses of these networks are used to compute their candidate functional or phenotypic states. Analysis of functional states of networks shows that the activity of biochemical reactions can be highly correlated in physiological states, forming so-called co ...
Jamshidi, Neema, Palsson, Bernhard Ø
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Stochastic Physics, Complex Systems and Biology [PDF]
In complex systems, the interplay between nonlinear and stochastic dynamics, e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in Darwinian sense, in terms of discrete jumps among attractors, with punctuated equilibrium ...
A Lasota+45 more
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SYSTEMS BIOLOGY. Systems biology (un)certainties.
How can modelers restore confidence in systems and computational biology?
Kirk, PDW, Babtie, AC, Stumpf, MPH
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Imaging in Systems Biology [PDF]
Most systems biology approaches involve determining the structure of biological circuits using genomewide "-omic" analyses. Yet imaging offers the unique advantage of watching biological circuits function over time at single-cell resolution in the intact animal.
Megason, Sean G., Fraser, Scott E.
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Borges Dilemma, Fundamental Laws, and Systems Biology [PDF]
I reason here that the known folk law in biology that there is no general law in biology because of exceptions is false. The (quantitative) systems biology offers the potential to solve the Borges Dilemma, by transcending it.
Ao, P
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Systems biology versus molecular biology [PDF]
Molecular biology and systems biology provide answers to the same questions, but the answers are quite different for the two approaches and are, on the surface, unrelated. The molecular biological answers are arguably more fundamental and are unique, but alternative systems biology answers are possible – consider the two systems-level answers to the ...
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Systems engineering to systems biology
Mol Syst Biol. 4: 185 The ‘bottom‐up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top‐down’ fashion, using a variety of network reverse engineering methods, data‐driven modeling and
Yıldırım, Muhammed A, Vidal, Marc
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Planetary Systems Biology [PDF]
Combining paleogenetics, protein engineering, synthetic biology, and metabolic modeling, a planetary biology perspective is brought to bear on adaptive evolutionary events in ancient bacteria.
Department of Chemistry, University of Florida, Gainesville, FL 32611 USA ( host institution )+2 more
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