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Current advances in systems and integrative biology [PDF]
, 2014 Systems biology has gained a tremendous amount of interest in the last few years. This is partly due to the realization that traditional approaches focusing only on a few molecules at a time cannot describe the impact of aberrant or modulated molecular ...
Fernandes, Marco +2 more
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Biophysics and systems biology [PDF]
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2010 Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded
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Systems chemical biology [PDF]
Nature Chemical Biology, 2007 The increasing availability of data related to genes, proteins and their modulation by small molecules has provided a vast amount of biological information leading to the emergence of systems biology and the broad use of simulation tools for data analysis.
Oprea, Tudor I +3 more
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Controlled vocabularies and semantics in systems biology [PDF]
, 2011 The use of computational modeling to describe and analyze biological systems is at the heart of systems biology. Model structures, simulation descriptions and numerical results can be encoded in structured formats, but there is an increasing need to ...
Courtot, Mélanie, Hucka, Michael
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Foundations of Theoretical Approaches in Systems Biology [PDF]
, 2018 AM-S was funded by the German Ministry of Education and Research (BMBF) projects OpHeLiA (0316197) and HOBBIT (031B0363A). RA funded by Generalitat de Catalunya Consolidated Group SGR133 (2017).
Alves, Rui +2 more
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The Biology of the Interferon System [PDF]
Nature Biotechnology, 1983 SCOPUS: ar.j ; info:eu-repo/semantics ...
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Small RNA biology is systems biology
BMB Reports, 2011 During the last decade small regulatory RNA (srRNA) emerged as central players in the regulation of gene expression in all kingdoms of life. Multiple pathways for srRNA biogenesis and diverse mechanisms of gene regulation may indicate that srRNA regulation evolved independently multiple times.
Jost, Daniel +2 more
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Static Analysis for Systems Biology [PDF]
, 2003 This paper shows how static analysis techniques can help understanding biological systems. Based on a simple example will illustrate the outcome of performing three different analyses extracting information of increasing precision.
Nielson, Flemming +3 more
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Erwin Schroedinger, Francis Crick and epigenetic stability [PDF]
, 2008 Schroedinger's book 'What is Life?' is widely credited for having played a crucial role in development of molecular and cellular biology. My essay revisits the issues raised by this book from the modern perspective of epigenetics and systems biology.
Ogryzko, Vasily
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Computational challenges of systems biology [PDF]
, 2004 Progress in the study of biological systems such as the heart, brain, and liver will require computer scientists to work closely with life scientists and mathematicians.
Finkelstein, A. +6 more
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