Results 41 to 50 of about 2,957,126 (345)
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
iScience, 2021 Summary: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of kidney cancer and has high heterogeneity. Stratification of ccRCC is important since distinct subtypes differ in prognosis and treatment.
Xiangyu Li +12 more
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Borges Dilemma, Fundamental Laws, and Systems Biology [PDF]
, 2007 I reason here that the known folk law in biology that there is no general law in biology because of exceptions is false. The (quantitative) systems biology offers the potential to solve the Borges Dilemma, by transcending it.
Ao, P
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iScience, 2021 Summary: Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Mutual exclusivity has been an empirically useful signal for identifying activating mutations that respond to single agent ...
Haider Inam +8 more
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Systems Biology, Integrative Biology, Predictive Biology [PDF]
Cell, 2005 The pursuit of science is based on empiricism enabled by advancing technologies. Theories then emerge that unify our understanding of natural order. The trinity of experimentation, theory, and technology that underlies the scientific method cannot be placed into a hierarchy of importance.
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Developments in the tools and methodologies of synthetic biology. [PDF]
, 2014 Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to ...
Freemont, P +3 more
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Universally Sloppy Parameter Sensitivities in Systems Biology [PDF]
, 2007 Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring \emph{in vivo}
Adam P Arkin +6 more
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, 2013 This is a contribution to the encyclopedia of systems biology on ...
Hüttemann, Andreas, Kaiser, Marie I.
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SBML models and MathSBML [PDF]
, 2008 MathSBML is an open-source, freely-downloadable Mathematica package that facilitates working with Systems Biology Markup Language (SBML) models. SBML is a toolneutral,computer-readable format for representing models of biochemical reaction networks ...
Shapiro, B.E. +9 more
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Cells, 2013 Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived
Bor-Sen Chen, Chia-Chou Wu
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Systems biology: The reincarnation of systems theory applied in biology? [PDF]
Briefings in Bioinformatics, 2001 With the availability of quantitative data on the transcriptome and proteome level, there is an increasing interest in formal mathematical models of gene expression and regulation. International conferences, research institutes and research groups concerned with systems biology have appeared in recent years and systems theory, the study of organisation
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