Results 51 to 60 of about 1,150,837 (304)
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Application of Gene Shaving and Mixture Models to Cluster Microarray Gene Expression Data
Cancer Informatics, 2007 Researchers are frequently faced with the analysis of microarray data of a relatively large number of genes using a small number of tissue samples. We examine the application of two statistical methods for clustering such microarray expression data ...
S. Wen, R. Bean, G.J. McLachlan, K-A. Do
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Cloning of DNA oligo pools for in vitro expression
STAR Protocols, 2022 Summary: Oligo library pools are powerful tools for systematic investigation of genetic and transcriptomic machinery such as promoter function and gene regulation, non-coding RNAs, or RNA modifications.
Anna Uzonyi, Ronit Nir, Schraga Schwartz
doaj +1 more source
The Meaning of Systems Biology [PDF]
Cell, 2005 With the new excitement about systems biology, there is understandable interest in a definition. This has proven somewhat difficult. Scientific fields, like species, arise by descent with modification, so in their earliest forms even the founders of great dynasties are only marginally different than their sister fields and species.
openaire +3 more sources
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic +2 more
wiley +1 more source
Cancer Informatics, 2007 The biological interpretation of gene expression microarray results is a daunting challenge. For complex diseases such as cancer, wherein the body of published research is extensive, the incorporation of expert knowledge provides a useful analytical ...
Jason H. Moore +2 more
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Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
iScience, 2021 Summary: Many players regulating the CD4+ T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing.
Christophe M. Capelle +6 more
doaj +1 more source
Systems chemical biology [PDF]
Nature Chemical Biology, 2007 The increasing availability of data related to genes, proteins and their modulation by small molecules has provided a vast amount of biological information leading to the emergence of systems biology and the broad use of simulation tools for data analysis.
Oprea, Tudor I +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Perturbation of Interaction Networks for Application to Cancer Therapy
Cancer Informatics, 2007 We present a computational approach for studying the effect of potential drug combinations on the protein networks associated with tumor cells.
Steven J. M. Jones +2 more
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