Results 61 to 70 of about 1,150,837 (304)

Systems cell biology [PDF]

Journal of Cell Biology, 2014
Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling to understand many critical processes that contribute to cellular organization and dynamics. Recently, there have been several advances in technology and in the application of modeling approaches that enable the exploration of the dynamic properties of ...
John D. Aitchison, John D. Aitchison, Fred D. Mast, Alexander V. Ratushny, Alexander V. Ratushny   +4 more
openaire   +4 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Protocol for an agent-based model of recombination in bacteria playing a public goods game

STAR Protocols, 2023
Summary: Agent-based models are composed of individual agents coded for traits, such as cooperation and cheating, that interact in a virtual world based on defined rules.
Isaiah Paolo A. Lee, Omar Tonsi Eldakar, J. Peter Gogarten, Cheryl P. Andam   +3 more
doaj   +1 more source

Yeast Systems Biology [PDF]

FEMS Yeast Research, 2008
Systems Biology (SB) is a rapidly developing field, which is expected to have a major impact on the future of biological and medical research. It aims at system-level understanding of biological processes employing mathematical analysis and computational tools to integrate the information content obtained in experimental biology.
Merja Penttilä, Jens Nielsen, Teun Boekhout   +2 more
openaire   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics

iScience, 2020
Summary: Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to ...
Munisha Smalley, Michelle Przedborski, Saravanan Thiyagarajan, Moriah Pellowe, Amit Verma, Nilesh Brijwani, Debika Datta, Misti Jain, Basavaraja U. Shanthappa, Vidushi Kapoor, Kodaganur S. Gopinath, D.C. Doval, K.S. Sabitha, Gaspar Taroncher-Oldenburg, Biswanath Majumder, Pradip Majumder, Mohammad Kohandel, Aaron Goldman   +17 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Deciphering sphingolipid biosynthesis dynamics in Arabidopsis thaliana cell cultures: Quantitative analysis amid data variability

iScience
Summary: Sphingolipids are pivotal for plant development and stress responses. Growing interest has been directed toward fully comprehending the regulatory mechanisms of the sphingolipid pathway.
Abraham Osinuga, Ariadna González Solís, Rebecca E. Cahoon, Adil Alsiyabi, Edgar B. Cahoon, Rajib Saha   +5 more
doaj   +1 more source

Small RNA biology is systems biology

BMB Reports, 2011
During the last decade small regulatory RNA (srRNA) emerged as central players in the regulation of gene expression in all kingdoms of life. Multiple pathways for srRNA biogenesis and diverse mechanisms of gene regulation may indicate that srRNA regulation evolved independently multiple times.
Jost, Daniel, Nowojewski, Andrzej, Levine, Erel   +2 more
openaire   +5 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source