Results 61 to 70 of about 2,989,026 (346)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell +14 more
wiley +1 more source
Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics
iScience, 2023 Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto +9 more
doaj +1 more source
Visualizing dimensionality reduction of systems biology data
, 2012 One of the challenges in analyzing high-dimensional expression data is the detection of important biological signals. A common approach is to apply a dimension reduction method, such as principal component analysis. Typically, after application of such a
A Hyvaerinen +31 more
core +1 more source
Systems biology and cancer, [Editorial] [PDF]
, 2011 The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome,
Maini, Philip +3 more
core +2 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Cancer Informatics, 2007 Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are of critical importance for cancer
Sean Martin +2 more
doaj
Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas
iScience, 2021 Summary: Deconstructing tissue-specific effects of genes and variants on proliferation is critical to understanding cellular transformation and systematically selecting cancer therapeutics.
Udit Parekh +8 more
doaj +1 more source
StochKit-FF: Efficient Systems Biology on Multicore Architectures [PDF]
, 2010 The stochastic modelling of biological systems is an informative, and in some cases, very adequate technique, which may however result in being more expensive than other modelling approaches, such as differential equations.
A. Perelson +7 more
core +2 more sources
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 Cell biologists are interested in how complexity arises from the interaction of different molecules. However, cells are many orders of magnitude larger than the protein-binding interfaces. To bridge these vast difference in scales, biologists construct hierarchies of organization of cellular structures.
openaire +3 more sources
Stem cell biology meets systems biology [PDF]
Development, 2009 Stem cells and their descendents are the building blocks of life. How stem cell populations guarantee their maintenance and/or self-renewal, and how individual stem cells decide to transit from one cell stage to another to generate different cell types are long-standing and fascinating questions in the field.
Roeder I, Radtke F.
openaire +1 more source