Results 41 to 50 of about 25,134,561 (338)

Tutorial for Using Control Systems Engineering to Optimize Adaptive Mobile Health Interventions

Journal of Medical Internet Research, 2018
Background Adaptive behavioral interventions are individualized interventions that vary support based on a person's evolving needs. Digital technologies enable these adaptive interventions to function at scale.
E. Hekler, D. Rivera, César A. Martín, Sayali S. Phatak, Mohammad T. Freigoun, E. Korinek, P. Klasnja, M. Adams, M. Buman   +8 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Enhancing Strategic Planning of Projects: Selecting the Right Product Development Methodology

Information, 2023
The selection of an appropriate development methodology is a critical strategic decision when managing a New Product Development (NPD) project. However, accurately estimating project duration based on the chosen methodology remains a challenge.
Itai Lishner, Avraham Shtub
doaj   +1 more source

Circular systems engineering

Software and Systems Modeling
The perception of the value and propriety of modern engineered systems is changing. In addition to their functional and extra-functional properties, nowadays' systems are also evaluated by their sustainability properties. The next generation of systems will be characterized by an overall elevated sustainability -- including their post-life, driven by ...
Istvan David, Dominik Bork, Gerti Kappel
openaire   +2 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Software Architecture Modeling of AUTOSAR-Based Multi-Core Mixed-Critical Electric Powertrain Controller

Modelling, 2021
In this paper, we present a transition journey of automotive software architecture design from using legacy approaches and toolchains to employing new modeling capabilities in the recent releases of Matlab/Simulink (M/S). We present the seamless approach
Sakthivel Manikandan Sundharam, Padma Iyenghar, Elke Pulvermueller   +2 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Systematic Design Approach for Functional Integration of Vehicular Wireless Power Transfers Modules

Computers, 2021
This paper presents a systematic design approach to the development of functionally integrated mechanical-electrical lightweight systems. The development of these systems requires the end-to-end consideration of all product domains involved, aspects of ...
Steve Zimmer, Martin Helwig, Peter Lucas, Anja Winkler, Niels Modler   +4 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Development of a Functional and Logical Reference System Architecture in Automotive Engineering

Systems
The automobile is evolving from a mechanically dominated to a cyber-physical, software-defined system. Future complex functionalities, such as autonomous driving, require multidisciplinary, interconnected systems.
Jonas Krog, Caner Akbas, Bastian Nolte, Thomas Vietor   +3 more
doaj   +1 more source