Results 51 to 60 of about 25,134,561 (338)

Digital Twinning From Vehicle Usage Statistics for Customer-Centric Automotive Systems Engineering

IEEE Open Journal of Intelligent Transportation Systems, 2023
Towards customer-centric automotive systems engineering, it is essential to incorporate physical models and vehicle usage behavior into decision support systems (DSSs).
Kunxiong Ling
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Site systems engineering: Systems engineering management plan [PDF]

, 1996
The Site Systems Engineering Management Plan (SEMP) is the Westinghouse Hanford Company (WHC) implementation document for the Hanford Site Systems Engineering Policy, (RLPD 430.1) and Systems Engineering Criteria Document and Implementing Directive, (RLID 430.1).
openaire   +2 more sources

On Systems of Systems Engineering: A Requirements Engineering Perspective and Research Agenda

IEEE International Requirements Engineering Conference, 2018
The emergence of Systems of Systems (SoSs) and Systems of Systems Engineering (SoSE) is largely driven by global societal needs including energy-water-food nexus, population demographics, global climate, integrated transport, security and social activity.
Cornelius Ncube, Soo Ling Lim
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

VISUAL MODELS OF SYSTEMS ENGINEERING OF ADDITIVE MANUFACTURING PROCESSES

Надежность и качество сложных систем
Background. The paper discusses methods for using visual systems engineering tools using the example of additive manufacturing processes. Materials and methods.
A.I. Vlasov, G.A. Volkov, K.V. Selivanov
doaj   +1 more source

Risk Analysis of Artificial Intelligence in Medicine with a Multilayer Concept of System Order

Systems
Artificial intelligence (AI) is advancing across technology domains including healthcare, commerce, the economy, the environment, cybersecurity, transportation, etc. AI will transform healthcare systems, bringing profound changes to diagnosis, treatment,
Negin Moghadasi, Rupa S. Valdez, Misagh Piran, Negar Moghaddasi, Igor Linkov, Thomas L. Polmateer, Davis C. Loose, James H. Lambert   +7 more
doaj   +1 more source

Modeling and Simulation-Based Systems Engineering Handbook

, 2018
NASA Centers. Aerospace Companies, and Modeling and Simulation Tool Providers Survey of Model Based Systems Engineering Methodologies (6), (7). – e.g. INCOSE (16) INCOSE Systems Engineering Handbook, v. 3.2.2, October.
D. Gianni, A. D’Ambrogio, A. Tolk
semanticscholar   +1 more source