Results 51 to 60 of about 4,654,755 (329)

Systems Engineering Leading Indicators Guide, Version 2.0 [PDF]

, 2010
The Systems Engineering Leading Indicators Guide editorial team is pleased to announce the release of Version 2.0. Version 2.0 supersedes Version 1.0, which was released in July 2007 and was the result of a project initiated by the Lean Advancement ...
International Council on Systems Engineering, Lean Advancement Initiative, Practical Software and Systems Measurement, Systems Engineering Advancement Research Initiative   +3 more
core  

occumb: An R package for site occupancy modeling of eDNA metabarcoding data

Population Ecology, EarlyView.
This study introduces a new R package, occumb, for the convenient application of site occupancy modeling using environmental DNA (eDNA) metabarcoding data. We outline a data analysis workflow, including data setup, model fitting, model assessment, and comparison of potential study settings based on model predictions, all of which can be performed using
Keiichi Fukaya, Yuta Hasebe
wiley   +1 more source

Between Droughts and Floods: The Seasonal Response of Freshwater Snails in Artificial Reservoirs in the Brazilian Semiarid Region

Population Ecology, EarlyView.
We investigate the seasonal dynamics of two freshwater snails, Biomphalaria straminea and Melanoides tuberculata, in artificial reservoirs of the Brazilian semiarid region. Despite regulated hydrology, B. straminea exhibited strong seasonal fluctuations associated with dry periods, while M. tuberculata maintained stable populations throughout the year,
Lucas Henrique Sousa da Silva, João Hemerson de Sousa, Adriana Josefa da Rocha, Manuella Feitosa Leal, Lucas Ariel de Sousa Aguiar, Tamaris Gimenez Pinheiro, Edson Lourenço da Silva   +6 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Development of a Functional and Logical Reference System Architecture in Automotive Engineering

Systems
The automobile is evolving from a mechanically dominated to a cyber-physical, software-defined system. Future complex functionalities, such as autonomous driving, require multidisciplinary, interconnected systems.
Jonas Krog, Caner Akbas, Bastian Nolte, Thomas Vietor   +3 more
doaj   +1 more source

Engineering Crowdsourced Stream Processing Systems [PDF]

, 2014
A crowdsourced stream processing system (CSP) is a system that incorporates crowdsourced tasks in the processing of a data stream. This can be seen as enabling crowdsourcing work to be applied on a sample of large-scale data at high speed, or ...
Carlos Castillo, Crp Henri Tudor, Ioanna Lykourentzou, Muhammad Imran, Yannick Naudet   +4 more
core  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Introducing systems engineering to industrial design engineering students with hands-on experience [PDF]

, 2005
The article presents an innovative educational project to introduce systems engineering to third year students in industrial design engineering at the University of Twente. In a short period the students are confronted with new technology, namely sensors
Bonnema, G. Maarten, Houten, Fred J.A.M. van, Lutters-Weustink, Ilanit F.   +2 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source