Results 61 to 70 of about 1,058,962 (296)

OVERVIEW OF AUTOMATION METHODS OF SMALL AND MEDIUM ENGINEERING ENTERPRISES BASED ON CALS-TECHNOLOGIES AND SYSTEMS ENGINEERING APPROACH

Вестник Донского государственного технического университета, 2018
The design techniques of integrated information systems development aimed at the life cycle support are reviewed. Cases of the CALS-technologies and systems engineering for building some typical models are considered. These models can be used for typical
Dmitry V. DUDKIN
doaj  

An Analytical Framework for Determining the Minimum Size of Highly Miniaturized Satellites: PlanarSats

Aerospace
This paper introduces a power-driven systems engineering methodology for the early-phase design of highly miniaturized satellites: PlanarSats. We derive an analytical framework linking power requirements, contingency policies, solar-cell performance, and
Mehmet Şevket Uludağ, Alim Rüstem Aslan   +1 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Power Contingency/Margin Methodology and Operational Envelope Analysis for PlanarSats

Aerospace
This paper presents a power-centric systems-engineering approach for PlanarSats and for atto-, and femto-class spacecraft where surface-limited power dominates design.
Mehmet Şevket Uludağ, Alim Rüstem Aslan   +1 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Semantic Priority Navigation for Energy-Aware Mining Robots

Systems
Autonomous navigation in subterranean mines is hindered by deformable terrain, dust-laden visibility, and densely packed, safety-critical machinery. We propose a systems-oriented navigation framework that embeds semantic priorities into reactive planning
Claudio Urrea, Kevin Valencia-Aragón, John Kern   +2 more
doaj   +1 more source

Knowledge Phenomenology Research on Disruptive Innovative Design of Future Industries [PDF]

中国工程科学
Innovative design serves as both a precursor and a foundational component in advancing future industries. It is also a key driver in fostering new quality productive forces.
Jiang Xu, Haoxiang Qu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Interfaces And Models In Interdisciplinary Integrative Product Creation

Proceedings of the Conference on Production Systems and Logistics
There is a shift from mechanical to mechatronic or cyber-physical products. Product development is also facing shorter product life cycles. The development of mechatronic or cyber-physical products requires interdisciplinary systems engineering that ...
Disselkamp, Jan-Philipp, Schütte, Ben, Lick, Jonas, Westphal, Svenja, Hoveman, Aschot, Dumitrescu, Roman   +5 more
doaj   +1 more source