Results 71 to 80 of about 779,188 (287)

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment

iScience
Summary: Motivationally significant events, such as rewards and threats, modify neural representations of the environment where they occur. The medial prefrontal cortex (mPFC) forms map-like representations anchored to these events.
Yangzi Chen, Gaqi Tu, Lizhe Zhang, Kaori Takehara-Nishiuchi   +3 more
doaj   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Sparse memory ensembles set brain-wide network states to sustain learned associations

iScience
Summary: The ability to recall spatial memories and adapt behavior to changing conditions underlies efficient navigation. These processes are thought to rely on sparse populations of neurons, embedded within distributed brain networks. Here, we sought to
Josué Haubrich, Gabriele Russo, Denise Manahan-Vaughan   +2 more
doaj   +1 more source

Efficient transfer entropy analysis of non-stationary neural time series

, 2014
Information theory allows us to investigate information processing in neural systems in terms of information transfer, storage and modification. Especially the measure of information transfer, transfer entropy, has seen a dramatic surge of interest in ...
Díaz-Pernas, Francisco J., Martínez-Zarzuela, Mario, Vicente, Raul, Wibral, Michael, Wollstadt, Patricia   +4 more
core   +3 more sources

Affect regulation: a systems neuroscience perspective [PDF]

Neuropsychiatric Disease and Treatment, 2005
TO INTEGRATE: (1) the neuroanatomical model of affect regulation; (2) a functional model of affect regulation; and (3) the evolving picture of affect dysregulation as exemplified by bipolar disorder.A computerized search for articles on related topics was augmented by additional selected studies.Subdivision between the orbitofrontal cortex (OFC) and ...
Mani N, Pavuluri, Ellen S, Herbener, John A, Sweeney   +2 more
openaire   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments [PDF]

, 2016
Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience.
Badura, A.M. (Aleksandra), Clopath, C. (Claudia), Schonewille, M. (Martijn), Zeeuw, C.I. (Chris) de   +3 more
core   +1 more source

Systems Neuroscience of Touch

Scholarpedia, 2015
Systems neuroscience attempts to understand the realization of brain-related functions at the level of organization that can be captured by logico-mathematical models (Von Bertalanffy, British Journal for the Philosophy of Science. 1: 134–165, 1950), such as those describing man-made systems.
Sebastian Haidarliu, Namrata Shinde, Ehud Ahissar   +2 more
openaire   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source