Results 61 to 70 of about 127,629 (199)

Adaptações biomecânicas do osso cortical de camundongos submetidos à três diferentes modalidades de exercício [PDF]

Acta Ortopédica Brasileira, 2013
OBJETIVO: Comparar os efeitos adaptativos de três modalidades de exercício de impacto reduzido nas adaptações mecânicas do osso cortical. MÉTODOS: Vinte e quatro camundongos machos, espécie Balb/c (25±3g), foram divididos aleatoriamente em quatro grupos (
Fernando Tadeu Trevisan Frajacomo, Maurício José Falcai, Cleverson Rodrigues Fernandes, Antonio Carlos Shimano, Sérgio Britto Garcia   +4 more
doaj   +2 more sources

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

EXPERIMENT AND SIMULATION ON MECHANICAL PROPERTIES OF OSTEOPOROTIC MOUSE BONE (MT)

Jixie qiangdu, 2023
The osteoporosis model of mouse tibia was established based on castration, and the effect of osteoporosis on the mechanical properties of tibia was investigated. The two-dimensional sections of mouse tibia were obtained by Micro-CT. The three-dimensional
ZHAO Qing, YIN ZiYang, ZHOU Wen, REN GuanLin, KUANG ChunMei, HU Cong, ZHOU ChangJiang   +6 more
doaj  

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Ankle Fractures Associated With Tibia Shaft Fractures Our Clinical Results and Review of Literature

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2018
Aim:Tibia shaft fracture is a common long bone fracture which might be seen along with tibia plateau, malleol and fibula fractures. It is known that posterior malleol fractures are the most frequent fracture type that accompany tibia shaft fractures.
Mahmut Kalem, Hakan Kocaoğlu, Ercan Șahin, M. Yağız Ayduğan   +3 more
doaj   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Radiographic Assessment of the Safe Zone for Medial Oblique Opening Wedge High Tibial Osteotomy

Journal of Orthopaedic Surgery, 2012
Purpose. To compare different cephalocaudal angles of the X-ray beam in measuring internal rotation of the proximal tibia that best demonstrates the safe zone. Methods. 10 pairs of embalmed, disarticulated knee joints from 10 cadavers were used.
Thana Siripisitsak, Bavornrat Vanadurongwan, Thos Harnroongroj, Thossart Harnroongroj   +3 more
doaj   +1 more source

How Effective is Fibula Pro Tibia Plating in Treatment of Distal Tibial Fractures: A Pilot Study [PDF]

Malaysian Orthopaedic Journal
Introduction: Despite recent advances, management of distal tibial fractures is challenging, with high rate of complications. Fibula pro tibia plating technique fixes fibula and tibia together, via laterally placed fibular plate without disturbing the ...
Jain S, Khare H, Verma K, Kumar U, Ajmera A   +4 more
doaj   +1 more source