Results 1 to 10 of about 381,920 (235)

T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells. [PDF]

J Fungi (Basel), 2022
T-2 toxin exposure could cause neurotoxicity; however, the precise molecular mechanisms remain unclear. In the present study, we investigated T-2 toxin-induced cytotoxicity and underlying molecular mechanisms using a mouse microglia BV2 cell line.
Sun T, Zhang Q, Li M, Tang S, Dai C.
europepmc   +2 more sources

Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity. [PDF]

Front Nutr, 2022
BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Jia Y, Shi S, Cheng B, Cheng S, Liu L, Meng P, Yang X, Chu X, Wen Y, Zhang F, Guo X.   +10 more
europepmc   +2 more sources

Peroxiredoxin 4 Ameliorates T-2 Toxin-Induced Growth Retardation in GH3 Cells by Inhibiting Oxidative Stress and Apoptosis. [PDF]

Molecules
T-2 toxin, a highly toxic type A trichothecene, is a secondary fungal metabolite produced by various Fusarium species. The consumption of food and feed contaminated with T-2 toxin is a major factor contributing to growth retardation, posing significant ...
Lu Q, Zhu Y, Wang L, Mei M, Qiu Y, Liu Y, Fu S, Xiong J, Guo P, Wu Z, Wang X.   +10 more
europepmc   +2 more sources

Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings. [PDF]

Poult Sci, 2023
: T-2 toxin is a dangerous natural pollutant and widely exists in animal feed, often causing toxic damage to poultry, such as slow growth and development, immunosuppression, and death. Although geese are considered the most sensitive poultry to T-2 toxin,
Gu W, Bao Q, Weng K, Liu J, Luo S, Chen J, Li Z, Cao Z, Zhang Y, Zhang Y, Chen G, Xu Q.   +11 more
europepmc   +2 more sources

Inflammation-related pathways involved in damaged articular cartilage of rats exposed to T-2 toxin based on RNA-sequencing analysis. [PDF]

Front Genet, 2022
Many studies have shown that ingestion of the T-2 toxin is harmful to articular cartilage. However, the mechanisms underlying damaged articular cartilage induced by T-2 toxin have not been elucidated.
Shi L, Liu Q, Yang H, Wang Q, Wang J, Fan Y.   +5 more
europepmc   +2 more sources

Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review. [PDF]

Anim Nutr
T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals.
Wang P, Sun LH, Wang X, Wu Q, Liu A.
europepmc   +2 more sources

T-2 Toxin-The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies. [PDF]

Molecules, 2021
Among trichothecenes, T-2 toxin is the most toxic fungal secondary metabolite produced by different Fusarium species. Moreover, T-2 is the most common cause of poisoning that results from the consumption of contaminated cereal-based food and feed ...
Janik E, Niemcewicz M, Podogrocki M, Ceremuga M, Stela M, Bijak M.   +5 more
europepmc   +2 more sources

Tibial Damage Caused by T-2 Toxin in Goslings: Bone Dysplasia, Poor Bone Quality, Hindered Chondrocyte Differentiation, and Imbalanced Bone Metabolism. [PDF]

Animals (Basel)
T-2 toxin, the most toxic type A trichothecene, is widely present in grain and animal feed, causing growth retardation and tissue damage in poultry. Geese are more sensitive to T-2 toxin than chickens and ducks.
Gu W, Hou L, Bao Q, Xu Q, Chen G.
europepmc   +2 more sources

Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures. [PDF]

Sci Rep
Despite being one of the most common contaminants of poultry feed, the molecular effects of T-2 toxin on the liver of the exposed animals are still not fully elucidated.
Vörösházi J, Mackei M, Sebők C, Tráj P, Márton RA, Horváth DG, Huber K, Neogrády Z, Mátis G.   +8 more
europepmc   +2 more sources

T-2 Toxin-Mediated β-Arrestin-1 O-GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation. [PDF]

Adv Sci (Weinh)
T‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury.
Li T, Sun W, Zhu S, He C, Chang T, Zhang J, Chen Y.   +6 more
europepmc   +2 more sources