T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells [PDF]
Journal of Fungi, 2022 T-2 toxin exposure could cause neurotoxicity; however, the precise molecular mechanisms remain unclear. In the present study, we investigated T-2 toxin-induced cytotoxicity and underlying molecular mechanisms using a mouse microglia BV2 cell line.
Tun Sun +4 more
doaj +3 more sources
Inflammation-related pathways involved in damaged articular cartilage of rats exposed to T-2 toxin based on RNA-sequencing analysis [PDF]
Frontiers in Genetics, 2022 Many studies have shown that ingestion of the T-2 toxin is harmful to articular cartilage. However, the mechanisms underlying damaged articular cartilage induced by T-2 toxin have not been elucidated.
Longyan Shi +5 more
doaj +3 more sources
Metabolism of HT-2 Toxin and T-2 Toxin in Oats [PDF]
Toxins, 2016 The Fusarium mycotoxins HT-2 toxin (HT2) and T-2 toxin (T2) are frequent contaminants in oats. These toxins, but also their plant metabolites, may contribute to toxicological effects. This work describes the use of 13C-assisted liquid chromatography–high-
Jacqueline Meng-Reiterer +5 more
doaj +3 more sources
T-2 toxin adsorption by hectorite [PDF]
Journal of the Serbian Chemical Society, 2009 The adsorption of T-2 toxin by the natural smectite mineral – hectorite at pH 3.0, 7.0 and 9.0 was investigated. The results of T-2 toxin adsorption on hectorite showed that the T-2 adsorption capacity decreased with increasing concentration of adsorbent
ALEKSANDRA DAKOVIĆ +5 more
doaj +4 more sources
Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity [PDF]
Frontiers in Nutrition, 2022 BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia +10 more
doaj +2 more sources
T-2 toxin-induced testicular impairment by triggering oxidative stress and ferroptosis
Ecotoxicology and Environmental Safety, 2023 T-2 toxin is a trichothecene mycotoxin of significant danger to humans and animals. Its impact on reproductive toxicity is attributed to oxidative stress, which ultimately leads to cell death.
Jun He +6 more
doaj +2 more sources
Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings [PDF]
Poultry Science, 2023 : T-2 toxin is a dangerous natural pollutant and widely exists in animal feed, often causing toxic damage to poultry, such as slow growth and development, immunosuppression, and death. Although geese are considered the most sensitive poultry to T-2 toxin,
Wang Gu +11 more
doaj +2 more sources
Peroxiredoxin 4 Ameliorates T-2 Toxin-Induced Growth Retardation in GH3 Cells by Inhibiting Oxidative Stress and Apoptosis [PDF]
MoleculesT-2 toxin, a highly toxic type A trichothecene, is a secondary fungal metabolite produced by various Fusarium species. The consumption of food and feed contaminated with T-2 toxin is a major factor contributing to growth retardation, posing significant ...
Qirong Lu +10 more
doaj +2 more sources
Detection of T-2 toxin by an improved radioimmunoassay [PDF]
Applied and Environmental Microbiology, 1983 T-2 toxin in serum, urine, and saline was analyzed by a modified radioimmunoassay procedure. The specimens were added directly to the assay tubes without extraction steps. The reaction between antibody and ligands was optimal at 1 h. Albumin-coated charcoal was used to separate bound from free radioactivity.
P A, Fontelo +3 more
openaire +3 more sources
Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. [PDF]
PLoS ONE, 2013 The trichothecene mycotoxin T-2 toxin is a common contaminant of food and feed and is also present in processed cereal derived products. Cytotoxic effects of T-2 toxin and its main metabolite HT-2 toxin are already well described with apoptosis being a ...
Maria Weidner +5 more
doaj +3 more sources