Metabolism of the Fusarium Mycotoxins T-2 Toxin and HT-2 Toxin in Wheat
Journal of Agricultural and Food Chemistry, 2015 To investigate the metabolic fate of HT-2 toxin (HT2) and T-2 toxin (T2) in wheat (Triticum aestivum L.), an untargeted metabolomics study utilizing stable isotopic labeling and liquid chromatography-high resolution mass spectrometry was performed. In total, 11 HT2 and 12 T2 derived in planta biotransformation products were annotated putatively.
Philipp Fruhmann +13 more
openaire +2 more sources
DOSE-RELATED GENOTOXIC EFFECT OF T-2 TOXIN MEASURED BY COMET ASSAY USING PERIPHERAL BLOOD MONONUCLEAR CELLS OF HEALTHY PIGS [PDF]
, 2013 T-2 toxin is the most acutely toxic trichothecene mycotoxin: it inhibits protein, DNA and RNA synthesis. The main goal of this study was to evaluate the rate of DNA damage caused by T-2 toxin in porcine mononuclear cells in increasing concentrations ...
Berta, Gergely +6 more
core +1 more source
Mitochondrial Damage Induced by T-2 Mycotoxin on Human Skin—Fibroblast Hs68 Cell Line
Molecules, 2023 T-2 toxin is produced by different Fusarium species and belongs to the group of type A trichothecene mycotoxins. T-2 toxin contaminates various grains, such as wheat, barley, maize, or rice, thus posing a risk to human and animal health.
Edyta Janik-Karpinska +5 more
doaj +1 more source
Detached leaf in vitro model for masked mycotoxin biosynthesis and subsequent analysis of unknown conjugates [PDF]
, 2014 The manuscript details the development of an in vitro model plant system using detached leaves because there is a need for biosynthetic methods for the production and isolation of masked mycotoxins.
Audenaert, Kris +7 more
core +2 more sources
Structure-function analysis of porcine cytochrome P450 3A29 in the hydroxylation of T-2 toxin as revealed by docking and mutagenesis studies. [PDF]
PLoS ONE, 2014 T-2 toxin, one of the type A trichothecenes, presents a potential hazard to human and animal health. Our previous work demonstrated that porcine cytochrome P450 3A29 (CYP3A29) played an important role in the hydroxylation of T-2 toxin.
Guyue Cheng +8 more
doaj +1 more source
Coexistence of Competing Microbial Strains under Twofold Environmental Variability and Demographic Fluctuations [PDF]
New J. Phys 25, 123010 (2023), 2023 Microbial populations generally evolve in volatile environments, under conditions fluctuating between harsh and mild, e.g. as the result of sudden changes in toxin concentration or nutrient abundance. Environmental variability thus shapes the long-time population dynamics, notably by influencing the ability of different strains of microorganisms to ...
arxiv +1 more source
Journal of Toxicologic Pathology, 2006 T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. This paper reviews the reported data about the development and/or mechanisms of T-2 toxin-induced apoptosis in the hematopoietic, lymphoid and gastrointestinal tissues, dorsal skin and fetal tissues of mice and rats.
Shinya Sehata +2 more
openaire +3 more sources
Toxin-mediated competition in weakly motile bacteria [PDF]
2019, J. Theor. Biol. 480 , 205-217, 2019 Many bacterial species produce toxins that inhibit their competitors. We model this phenomenon by extending classic two-species Lotka-Volterra competition in one spatial dimension to incorporate toxin production by one species. Considering solutions comprising two adjacent single-species colonies, we show how the toxin inhibits the susceptible species ...
arxiv +1 more source
miR449a/SIRT1/PGC-1α Is Necessary for Mitochondrial Biogenesis Induced by T-2 Toxin
Frontiers in Pharmacology, 2018 T-2 toxin is one of the type A trichothecenes produced mainly by the Fusarium genus. Due to its broad distribution and highly toxic nature, it is of great concern as a threat to human health and animal breeding.
Shijie Ma +8 more
doaj +1 more source
T-2 Toxin-Mediated β-Arrestin-1 O-GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation. [PDF]
Adv Sci (Weinh)T‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury.
Li T +6 more
europepmc +2 more sources