Results 201 to 210 of about 212,422 (259)
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The Structure of T-Cell Epitopes
Annual Review of Immunology, 1987We have reviewed here studies using synthetic peptides to analyze some of the properties of T-cell epitopes. Several general conclusions can be drawn. First, T-cell epitopes can usually be defined by linear sequences of about seven amino acids. However, the observation that increasing peptide length often results in increased antigenic potency has ...
A M, Livingstone, C G, Fathman
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Annals of Allergy, Asthma & Immunology, 2009
To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology.The PubMed database was searched for articles published from January 1, 1990, through December 31, 2008, for primary and review articles on T-cell epitope mapping. The keywords searched were CD4 T cell, major histocompatibility complex
Raija K S, Ahmed, Markus J, Maeurer
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To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology.The PubMed database was searched for articles published from January 1, 1990, through December 31, 2008, for primary and review articles on T-cell epitope mapping. The keywords searched were CD4 T cell, major histocompatibility complex
Raija K S, Ahmed, Markus J, Maeurer
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Annual Review of Immunology, 2020
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity ...
Peters, Bjoern +2 more
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Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity ...
Peters, Bjoern +2 more
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T-cell epitopes of aeroallergens
Annals of Allergy, Asthma & Immunology, 2009To describe the current knowledge of the T-cell epitopes of common aeroallergens, how they were discovered, and implications for future therapy.PubMed search of English-language articles without date limits pertaining to T-cell epitopes of aeroallergens included on a standard skin test panel.A total of 127 articles were screened based on the results of
Adrian G, Letz, Christopher W, Calabria
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The credentials of a T-cell epitope
Immunology Today, 1995Abstract The molecular events that culminate in the generation of T-cell effector function against an antigenic peptide were reviewed at a recent meeting *
R, Lechler, M, Pla
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The validity of predicted T-cell epitopes
Trends in Biotechnology, 2006High-performing MHC class I binding predictions have been available for more than a decade; however, their value in terms of actual epitope finding has only now been estimated in a large-scale investigation undertaken by the group of Sette. This work underlines the importance of bioinformatics as a resource-saving tool in the field of epitope discovery.
Claus, Lundegaard +2 more
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T-cell epitope discovery technologies
Human Immunology, 2014Despite tremendous potential utility in clinical medicine and research, the discovery and characterization of T-cell antigens has lagged behind most other areas of health research in joining the high-throughput '-omics' revolution. Partially responsible for this is the complex nature of the interactions between effector T cells and antigen-presenting ...
Govinda, Sharma, Robert A, Holt
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Current Opinion in Immunology, 1996
Synthetic approaches to T-cell epitope determination have recently been developed that complement the search for natural T-cell epitopes and the investigation of the preferences of the different MHC alleles for particular motifs in cognate peptide sequences. The combination of these different strategies opens new possibilities for basic, as well as for
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Synthetic approaches to T-cell epitope determination have recently been developed that complement the search for natural T-cell epitopes and the investigation of the preferences of the different MHC alleles for particular motifs in cognate peptide sequences. The combination of these different strategies opens new possibilities for basic, as well as for
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Identification of Epitope-Specific T Cells in T-Cell Receptor Repertoires
2020Recognition of cancer epitopes by T cells is fundamental for the activation of targeted antitumor responses. As such, the identification and study of epitope-specific T cells has been instrumental in our understanding of cancer immunology and the development of personalized immunotherapies.
Gielis, Sofie +6 more
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2003
The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen-presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules ...
A A, Delvig, J H, Robinson
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The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen-presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules ...
A A, Delvig, J H, Robinson
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