Results 211 to 220 of about 212,422 (259)

T-Cell Antigens and Epitopes in Schistosomiasis

1990
An ideal vaccine must duplicate the stimulus of natural infection and minimize the side effects that can interfere with its efficiency. New approaches to vaccine development using protein subunits or synthetic polypeptides must consider the problem of designing vaccines in such a way as to obtain optimal T-cell activity.
C, Auriault, I, Wolowczuk, M, Damonneville, F, Velge-Roussel, V, Pancré, H, Grass-Masse, A, Tartar, A, Capron   +7 more
openaire   +2 more sources

Databases for T-Cell Epitopes

2014
Modem immunology and vaccinology incorporate immunoinformatics techniques to give insights into immune systems and accelerate vaccine design. Databases managing epitope data in a structured form with immune-related annotations including sequences, alleles, source organisms, structures, and diseases could be the most crucial part of immunoinformatics ...
openaire   +2 more sources

Activation of T cells through a T cell-specific epitope of CD45

Cellular Immunology, 1992
The 180- and 190-kDa isoforms of CD45 are preferentially expressed on the helper inducer (memory) subset of CD4 cells. In order to generate monoclonal antibodies against the extracellular domains of these isoforms and determine whether they could regulate the function and activation of these cells, we developed a mAb, anti-4H2D, by immunizing Balb/c ...
Y, Torimoto, N H, Dang, M, Streuli, D M, Rothstein, H, Saito, S F, Schlossman, C, Morimoto   +6 more
openaire   +2 more sources

T-Cell Epitope Prediction

2017
An epitope is a part of an immunogenic protein that can be recognized by the immune system. The peptides that can be recognized by the T-cell receptors after a particular antigen has been intracellularly processed, bound to at least one MHC molecule and expressed on the surface of the antigen presenting cell as a MHC-peptide complex, are called a T ...
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T-Cell Epitope Processing (The Epitope Flanking Regions Matter)

2009
Epitopes presented by major histocompatibility complex (MHC) class I molecules for cytotoxic T-lymphocyte (CTL) recognition are derived mainly from cytosolic proteins. Antigen presentation on the cell surface requires correct processing of epitopes by the proteasome, cytosolic and endoplasmic reticulum (ER) aminopeptidases, efficient TAP transport, and
Alejandra Nacarino, Martinez, Stefan, Tenzer, Hansjörg, Schild   +2 more
openaire   +2 more sources

T-Cell Epitopes of Food Allergens

Clinical Reviews in Allergy & Immunology, 2006
During recent years, a great deal of research has focused on the identification of food allergens, their characterization at the molecular level, and the investigation of immunological mechanisms responsible for food hypersensitivity. Allergen-reactive T-helper 2 cells play a central role in the pathophysiology of allergic diseases.
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Bioinformatics Tools for the Prediction of T-Cell Epitopes

2018
T-cell responses are activated by specific peptides, called epitopes, presented on the cell surface by MHC molecules. Binding of peptides to the MHC is the most selective step in T-cell antigen presentation and therefore an essential factor in the selection of potential epitopes.
Andreatta, Massimo, Nielsen, Morten
openaire   +3 more sources

Mapping T cell epitopes by flow cytometry

Methods, 2003
Epitope mapping by flow cytometry is a very modern approach that not only identifies T-cell epitopes but simultaneously allows for detailed analysis of the responding T-cell subsets including lineage, activation marker expression, and other markers of interest.
Bodo, Hoffmeister, Felix, Kiecker, Lydia, Tesfa, Hans-Dieter, Volk, Louis J, Picker, Florian, Kern   +5 more
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Use of T Cell Epitopes for Vaccine Development

Current Drug Target -Infectious Disorders, 2001
T lymphocytes play a major role in the recognition and subsequent elimination of tumors and intracellular pathogens. Induction of epitope-specific T cell responses can help in the clearance of diseases for which no conventional vaccines exist. However, the lack of simple methods to identify relevant T cell epitopes, the high mutation rate of many ...
H, Sbai, A, Mehta, A S, DeGroot
openaire   +2 more sources

T-Cell Epitope Prediction of Chikungunya Virus

2016
There has been a growing demand for vaccines against Chikungunya virus (CHIKV), and epitope-based vaccine is a promising solution. Identification of CHIKV T-cell epitopes is critical to ensure successful trigger of immune response for epitope-based vaccine design.
Christine Loan Ping, Eng, Tin Wee, Tan, Joo Chuan, Tong   +2 more
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