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T-Cell Epitopes of Food Allergens
Clinical Reviews in Allergy & Immunology, 2006During recent years, a great deal of research has focused on the identification of food allergens, their characterization at the molecular level, and the investigation of immunological mechanisms responsible for food hypersensitivity. Allergen-reactive T-helper 2 cells play a central role in the pathophysiology of allergic diseases.
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Bioinformatics Tools for the Prediction of T-Cell Epitopes
2018T-cell responses are activated by specific peptides, called epitopes, presented on the cell surface by MHC molecules. Binding of peptides to the MHC is the most selective step in T-cell antigen presentation and therefore an essential factor in the selection of potential epitopes.
Andreatta, Massimo, Nielsen, Morten
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Mapping T cell epitopes by flow cytometry
Methods, 2003Epitope mapping by flow cytometry is a very modern approach that not only identifies T-cell epitopes but simultaneously allows for detailed analysis of the responding T-cell subsets including lineage, activation marker expression, and other markers of interest.
Bodo, Hoffmeister +5 more
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Use of T Cell Epitopes for Vaccine Development
Current Drug Target -Infectious Disorders, 2001T lymphocytes play a major role in the recognition and subsequent elimination of tumors and intracellular pathogens. Induction of epitope-specific T cell responses can help in the clearance of diseases for which no conventional vaccines exist. However, the lack of simple methods to identify relevant T cell epitopes, the high mutation rate of many ...
H, Sbai, A, Mehta, A S, DeGroot
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T-Cell Epitope Prediction of Chikungunya Virus
2016There has been a growing demand for vaccines against Chikungunya virus (CHIKV), and epitope-based vaccine is a promising solution. Identification of CHIKV T-cell epitopes is critical to ensure successful trigger of immune response for epitope-based vaccine design.
Christine Loan Ping, Eng +2 more
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SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors
Immunity, 2020Dmitry Kiryukhin +2 more
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Immunoinformatic Analysis of T- and B-Cell Epitopes for SARS-CoV-2 Vaccine Design
Vaccines, 2020Naidong Wang, Yang Zhan, Yi Yang
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