Results 81 to 90 of about 14,413,699 (306)

Differential narrow focusing of immunodominant human immunodeficiency virus Gag-specific cytotoxic T-Lymphocyte responses in infected African and Caucasoid adults and children [PDF]

, 2000
Cytotoxic T-lymphocyte (CTL) activity plays a central role in control of viral replication and in determining outcome in cases of human immunodeficiency virus type 1 (HIV-1) infection.
Ogg, GS, Coovadia, HM, O'Callaghan, CA, Kalams, SA, Mngqundaniso, N., Altfeld, M.A., Hammond, M., He, S, He, S., O'Callaghan, C.A., Tang, Y, Burchett, S.A., Walker, B.D., Rosenberg, ES, Burchett, SA, Pelton, SI, McIntosh, K, Annamalai, K, Annamalai, K., Cao, H, Walker, BD, Bunce, M, McIntosh, K., Coovadia, H.M., Kalams, S.A., Rosenberg, E.S., Govender, U., Brander, C, Goulder, P.J.R., Brander, C., Goulder, PJ, Hammond, M, O'Callaghan, Christopher, Mngqundaniso, N, Cao, H., Altfeld, MA, Ogg, G.S., Hartman, K.E., Pelton, S.I., Govender, U, Hartman, KE, Tang, Y., Bunce, M.   +42 more
core   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Identification of a human cyclin D1-derived peptide that induces human cytotoxic CD4 T cells. [PDF]

PLoS ONE, 2009
Cyclin D1 is over-expressed in various human tumors and therefore can be a potential oncogenic target antigen. However, only a limited number of T cell epitopes has been characterized. We aimed at identifying human cyclin D1-derived peptides that include
Tao Dao, Tatyana Korontsvit, Victoria Zakhaleva, Kurtis Haro, Jonathan Packin, David A Scheinberg   +5 more
doaj   +1 more source

Induction of cytolytic T lymphocytes directed towards the V3 loop of the human immunodeficiency virus type 1 external glycoprotein gp120 by p55gag/V3 chimeric vaccinia viruses [PDF]

, 1993
T cell-mediated cytotoxicity may play an important role in controlling infection by human immunodeficiency virus (HIV). In order to study the ability of rationally designed antigens to induce cytolytic T lymphocytes (CTLs) we replaced stretches of 30 to ...
Deml, Ludwig, Böltz, T., Wagner, Ralf, Modrow, Susanne, Wolf, Hans J.   +4 more
core   +1 more source

Prediction of T and B Cell Epitopes in the Proteome of SARS-CoV-2 for Potential Use in Diagnostics and Vaccine Design [PDF]

, 2020
The world is currently battling the Covid-19 pandemic for which there is no therapy available. Prophylactic measures like vaccines can effectively thwart the disease burden.
Parvez, Slathia, Preeti Sharma, (8701554), Parvez Slathia (8701551), Preeti, Sharma,   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Computational assembly of a human Cytomegalovirus vaccine upon experimental epitope legacy

BMC Bioinformatics, 2019
Background Human Cytomegalovirus (HCMV) is a ubiquitous herpesvirus affecting approximately 90% of the world population. HCMV causes disease in immunologically naive and immunosuppressed patients.
Monica J. Quinzo, Esther M. Lafuente, Pilar Zuluaga, Darren R. Flower, Pedro A. Reche   +4 more
doaj   +1 more source

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes [PDF]

, 2009
Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and ...
Patel, Ah, Ball Jonathan K., Nicasio Mancini, Nicola Clementi, Sautto, G, Clementi, N., Ball, J.K., Diotti, R.A., Burioni, R., Mario Perotti, Arvind H Patel, Nitti Giovanni, Diotti, Ra, Clementi Massimo, CLEMENTI, NICOLA, BURIONI, ROBERTO, Sautto, G., CLEMENTI, MASSIMO, Perotti, M., Jonathan K Ball, Massimo Clementi, Nitti, G, Giovanni Nitti, Patel, A.H., Clementi, M., Perotti Mario, Ball, Jk, Perotti, M, Patel Arvind H., Roberta A Diotti, Giuseppe Sautto, Mancini Nicasio, Diotti Roberta A., Mancini, N., Roberto Burioni, Sautto Giuseppe, MANCINI, NICASIO, Clementi Nicola, Burioni Roberto, Nitti, G.   +39 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source