Results 91 to 100 of about 2,073,683 (216)

TRain: T-cell receptor automated immunoinformatics

BMC Bioinformatics
Background The scarcity of available structural data makes characterizing the binding of T-cell receptors (TCRs) to peptide-Major Histocompatibility Complexes (pMHCs) very challenging.
Austin Seamann, Maia Bennett-Boehm, Ryan Ehrlich, Anna Gil, Liisa Selin, Dario Ghersi   +5 more
doaj   +1 more source

T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis

Frontiers in Immunology
BackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB).
Fengjiao Du, Yunyun Deng, Ling Deng, Boping Du, Aiying Xing, Hong Tao, Hua Li, Li Xie, Xinyong Zhang, Tao Sun, Tao Sun, Hao Li, Hao Li   +12 more
doaj   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, IAH, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Royal (Dick) School of Veterinary Studies, ILRI, Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +44 more
core   +1 more source

Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites.

, 2006
Protective immune responses against malaria are induced by immunization with radiation-attenuated Plasmodium sporozoites. In contrast, non-viable, heat-killed sporozoites do not induce protection, emphasizing the requirement for live parasites to achieve
Morrot, Alexandre, Rai, Urvashi, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Zavala, Fidel, Urvashi Rai, Dabeiba Bernal-Rubio, Bernal-Rubio, Dabeiba, Julius C. R. Hafalla   +11 more
core   +1 more source

Chimeric antigen receptor T-cell therapy for T-cell acute lymphoblastic leukemia

Haematologica
Chimeric antigen receptor (CAR) T-cell therapy is a new and effective treatment for patients with hematologic malignancies. Clinical responses to CAR T cells in leukemia, lymphoma, and multiple myeloma have provided strong evidence of the antitumor ...
Bernice L.Z. Oh, Natasha Vinanica, Desmond M.H. Wong, Dario Campana   +3 more
doaj   +1 more source

T-cell clones and T-cell receptors [PDF]

Microbiological Reviews, 1986
openaire   +2 more sources

No life without death--apoptosis as prerequisite for T cell activation.

, 2005
The orchestrated death of infected cells is key to our understanding of CD8 T cell activation against pathogens. Most intracellular bacteria including Mycobacterium tuberculosis, the etiologic agent of tuberculosis, remain enclosed in phagosomes of ...
Winau, F, Schaible, UE, Hegasy, Guido, Kaufmann, Stefan H. E., Schaible, Ulrich E., Hegasy, G, Winau, Florian, Kaufmann, SHE   +7 more
core   +1 more source

Chimeric antigen receptor-T cell therapy for T cell-derived hematological malignancies

Experimental Hematology & Oncology
Relapsed/refractory T cell-derived malignancies present with high heterogeneity and poor prognoses. Recently, chimeric antigen receptor (CAR)-T cell therapy has shown remarkable safety and efficacy in the treatment of B cell-derived malignancies. However,
Haiqiong Zheng, Houli Zhao, Shi Han, Delin Kong, Qiqi Zhang, Mingming Zhang, Yijin Chen, Meng Zhang, Yongxian Hu, He Huang   +9 more
doaj   +1 more source

The Human T-Cell Receptor

Annual Review of Immunology, 1984
Meuer, S, Acuto, O, Hercend, T, Schlossman, S, Reinherz, E   +4 more
openaire   +3 more sources

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

, 2007
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E, Rowbotham, NJ, Crompton, T, Dyson, J, Shah, DK, Cebecauer, M, Hager-Theodorides, AL, Outram, SV   +7 more
core