Results 71 to 80 of about 2,073,683 (216)

Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]

, 2002
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Nigel John Burroughs, Burroughs, Nigel John, Wülfing, Christoph, Christoph Wülfing   +3 more
core   +1 more source

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M, Allgaier, Rachel, Marcus Altfeld, Feeney, Margaret, Williams, KL, Sivamurthy, R, Pereyra, F, Allgaier, R, Rohini Sivamurthy, Stanley K. Mui, Rosenberg, Eric S, Allen, Todd M, Altfeld, M, Eric S. Rosenberg, Pereyra, Florencia, Rachel Allgaier, Trocha, Alicja, Todd M. Allen, Moza, Beenu, Allen, TM, Eric J. Sundberg, Mui, SK, Bruce D. Walker, Sundberg, EJ, Katie L. Williams, Gandhi, RT, Yu, Xu G, Rachel Allen, Daniel G. Kavanagh, Beenu Moza, Sundberg, Eric J, Alicja Trocha, Gandhi, Rajesh T, Moza, B, Margaret Feeney, Xu G. Yu, Rosenberg, ES, Mui, Stanley K, Mathias Lichterfeld, Florencia Pereyra, Walker, BD, Rajesh T. Gandhi, Sivamurthy, Rohini, Kavanagh, DG, Trocha, A, Lichterfeld, Mathias, Allen, R, Lichterfeld, M, Williams, Katie L, Allen, Rachel, ToshiYuki Miura, Miura, ToshiYuki, Walker, Bruce D, Miura, T, Yu, XG, Kavanagh, Daniel G, Altfeld, Marcus   +56 more
core   +1 more source

Global Manufacturing of CAR T Cell Therapy

Molecular Therapy: Methods & Clinical Development, 2017
Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates in patients with B cell malignancies, and chimeric antigen receptor T cell therapy is now being investigated in several hematologic and solid tumor types.
Bruce L. Levine, James Miskin, Keith Wonnacott, Christopher Keir   +3 more
doaj   +1 more source

Use of monoclonal antibodies to study alloreactivity and T cell development in Xenopus [PDF]

, 1993
This study investigated T-cell surface antigenic changes in the spleen of Xenopus following in vivo and in vitro allergenic challenge, using novel mouse monoclonal antibodies (mAb's) against all T cells (CDS), the putative ɑβ-T cell receptor (TCR), the ...
Paul, Tina
core  

Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia

OncoImmunology, 2018
Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed ...
Takero Shindo, Kazutaka Kitaura, Hiroshi Ureshino, Kazuharu Kamachi, Masaharu Miyahara, Kazuko Doi, Tatsuro Watanabe, Eisaburo Sueoka, Tadasu Shin-I, Ryuji Suzuki, Shinya Kimura   +10 more
doaj   +1 more source

Analysis of the paired TCR α- and β-chains of single human T cells. [PDF]

, 2012
Analysis of the paired i.e. matching TCR α- and β-chain rearrangements of single human T cells is required for a precise investigation of clonal diversity, tissue distribution and specificity of protective and pathologic T-cell mediated immune responses.
Dornmair, K., Besgen, P., Held, K., Bhonsle, L., Vollmer, Sigrid, Song-Min Kim, Jens Nickel, Anna Backes, Held, Kathrin, Vollmer, S., Joerg C Prinz, Backes Anna, Backes, A., Backes, Anna, Bhonsle, Latika, Kim Song-Min, Nickel, Jens, Sigrid Vollmer, Nickel, J., Kim, Song-Min, Klaus Dornmair, Dornmair, Klaus, Kim, S., Besgen Petra, Petra Besgen, Vollmer Sigrid, Prinz, Joerg C., Prinz Joerg C., Latika Bhonsle, Bhonsle Latika, Besgen, Petra, Held Kathrin, Prinz, J., Kathrin Held, Nickel Jens, Dornmair Klaus   +35 more
core   +1 more source

Rare event simulation for probabilistic models of T-cell activation

, 2010
Lipsmeier F. Rare event simulation for probabilistic models of T-cell activation. Bielefeld (Germany): Bielefeld University; 2010.One of the central questions in immunobiology is: How does the immune system reliably distinguish between antigens of our ...
Lipsmeier, Florian
core  

Chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma: opportunities and challenges

, 2019
B-cell non-Hodgkin lymphoma (NHL) is the most frequent hematologic malignancy. Despite the refinement of chemoimmunotherapy, a substantial number of patients experience chemorefractory disease.
Saiko Kurosawa, Katsuaki Imaizumi, Shinichi Makita, Kensei Tobinai   +3 more
core   +1 more source

The T cell antigen receptor [PDF]

Biochemical Journal, 1985
M K, Collins, M J, Owen
openaire   +2 more sources

Studies of suppression using monoclonal regulatory T cells and the importance of co-receptor Lck coupling ratios for negative selection [PDF]

, 2015
Normal physiology is not given without immunological tolerance. Depending on the origin of induction, tolerance can be divided into central and peripheral tolerance.
Gubser, Céline
core   +1 more source