Results 71 to 80 of about 16,833,685 (312)
Вестник трансплантологии и искусственных органов, 2016 Immunological allograft rejection is based on the process of recognition of donor antigens by T-cell receptors. Antigens are generally represented by molecules of major hystocompatibility complex (MHC), expressed by the donor organ tissue cells.
A. S. Berkos, G. V. Nikolaev
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
Studies on the affinity control of T cell development [PDF]
, 2004 Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad +9 more
wiley +1 more source
Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]
, 1996 To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E. +2 more
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Chimeric Antigen Receptor-T Cell Therapy
HemaSphere, 2018 . Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR.
Jochen Buechner +4 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi +9 more
wiley +1 more source
Modulatory effects of T-cadherin on cell behavior and growth factor receptor activity in carcinoma cells [PDF]
, 2014 Cancer is a major health problem. Epidermal growth factor receptor (EGFR) pathway plays an important role in cancer progression. EGFR-targeted anti-cancer drugs are being developed to improve anti-cancer therapy.
Maslova, Kseniya
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola +4 more
wiley +1 more source
Novel chimeric antigen receptor T cells based on T-cell receptor-like antibodies
Blood Science, 2019 . The need for novel therapeutics against human cancers such as leukemias and solid tumors is well recognized. Human T cells are poised to make a fundamental change in the therapeutic approach. T-cell interaction with a tumor cell is a critical event and
Qi Zhao
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