Chimeric Antigen Receptor-T Cell Therapy
HemaSphere, 2018 . Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR.
Jochen Buechner +4 more
doaj +1 more source
Disentangled Wasserstein Autoencoder for T-Cell Receptor Engineering [PDF]
arXiv, 2022 In protein biophysics, the separation between the functionally important residues (forming the active site or binding surface) and those that create the overall structure (the fold) is a well-established and fundamental concept. Identifying and modifying those functional sites is critical for protein engineering but computationally non-trivial, and ...
arxiv
Chimeric antigen receptor T cell persistence and memory cell formation
Immunology and Cell Biology, 2019 It is now becoming clear that less differentiated naive and memory T cells are superior to effector T cells in the transfer of immunity for adoptive cell therapy.
A. McLellan, S. M. Ali Hosseini Rad
semanticscholar +1 more source
Crossreactivity of the T-cell receptor [PDF]
Immunology Today, 1998 In this issue of Immunology Today, Don Mason argues that T cells should be highly degenerate in order to allow an immune response against any T-cell epitope. Because the number of possible epitopes is indeed much larger than the number of T-cell clonotypes in any immune system, we fully agree that each clonotype should recognize many epitopes ...
Borghans, J.A.M., Boer, R.J. de
openaire +3 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
T-cell abnormalities are present at high frequencies in patients with hypereosinophilic syndrome
Haematologica, 2009 Background A T-cell clone, thought to be the source of eosinophilopoietic cytokines, identified by clonal rearrangement of the T-cell receptor and by the presence of aberrant T-cell immunophenotype in peripheral blood defines lymphocytic variant of ...
Grzegorz Helbig +4 more
doaj +1 more source
CAR‐T‐OPENIA: Chimeric antigen receptor T‐cell therapy‐associated cytopenias
eJHaem, 2022 Chimeric antigen receptor (CAR) T‐cell is the most recent version in the evolution of cellular therapy with promising responses, which has revolutionized the management of some hematological malignancies in the current times.
Alankrita Taneja, Tania Jain
doaj +1 more source
A new approach to understanding T cell development: the isolation and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by subtraction cloning [PDF]
, 1992 During T cell development in the mammalian thymus, immature T cells are observed that lack the cell surface markers CD4, CD8, and CD3. A subtracted cDNA library was constructed to isolate cDNAs that are specific for these immature T cells.
Gese, Elaine, Hood, Leroy, Orr, Sally L.
core
Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment. [PDF]
, 2008 Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site.
B H Belohradsky +7 more
core +1 more source
High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities
Briefings Bioinform., 2017 &NA; T‐cell specificity is determined by the T‐cell receptor, a heterodimeric protein coded for by an extremely diverse set of genes produced by imprecise somatic gene recombination.
J. Heather +3 more
semanticscholar +1 more source