Results 201 to 210 of about 2,701,466 (355)

Spatial Proximity of LAG-3 and T Cell Receptor: A New Paradigm for T Cell Suppression. [PDF]

MedComm (2020)
Miao X, Feng X, Zhou F.
europepmc   +1 more source

Clonal rearrangements of T-cell receptor and immunoglobul in genes as sensitive marker for bone marrow involvement in non-Hodgkin's lymphoma [PDF]

, 1986
Martin Krönke, G. Krieger, Michael Kneba, Georg Nagel, Klaus Pfizenmaier   +4 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex. [PDF]

Nat Commun
Notti RQ, Yi F, Heissel S, Bush MW, Molvi Z, Das P, Molina H, Klebanoff CA, Walz T.   +8 more
europepmc   +1 more source

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8⁺T cell responses in nonhuman primates

, 2005
Ulrike Wille-Reece, Barbara J. Flynn, Karin Loré, Richard A. Koup, Ross M. Kedl, Joseph J. Mattapallil, Walter R. Weiss, Mario Roederer, Robert A. Seder   +8 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

ALIGaToR: a tool for the automated annotation of immunoglobulin and T cell receptor genomic loci. [PDF]

Oxf Open Immunol
Schramm CA, Olubo S, Douek DC.
europepmc   +1 more source

T-Cell Receptor [PDF]

, 2020
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

TRAIT: A Comprehensive Database for T-cell Receptor-antigen Interactions. [PDF]

Genomics Proteomics Bioinformatics
Wei M, Wu J, Bai S, Zhou Y, Chen Y, Zhang X, Zhao W, Chi Y, Pan G, Zhu F, Chen S, Zhou Z.   +11 more
europepmc   +1 more source