Results 281 to 290 of about 2,701,466 (355)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

B- and T cell receptor sequencing elucidates characteristics of lymphocyte depletion by ocrelizumab. [PDF]

iScience
Schneider-Hohendorf T, Wünsch C, Schulte-Mecklenbeck A, Revie L, Raposo C, Strauli N, Tackenberg B, Lünemann JD, Gross CC, Klotz L, Wiendl H, Schwab N.   +11 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Correction to: SLAMF6 regulates basal T cell receptor signaling and influences invariant natural killer T cell lineage diversity. [PDF]

Int Immunol
europepmc   +1 more source

Circulating T-cell receptor repertoire and clinicopathological correlations in breast cancer patients: immune repertoire analysis from the VGH-TAYLOR study. [PDF]

Breast Cancer Res
Tseng LM, Huang CC, Chen JL, Tsai YF, Chao TC, Wu WC, Lien PJ, Lin YS, Feng CJ, Chen YJ, Lai JI, Chiu JH, Hsu CY, Liu CY.   +13 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Current developments in T-cell receptor therapy for acute myeloid leukemia. [PDF]

Blood Adv
Gore S, Blyth E, Bleakley M, Lee K, Micklethwaite K, Gowrishankar K.   +5 more
europepmc   +1 more source

Reviewer #3 (Public Review): The T Cell Receptor β Chain Repertoire of Tumor Infiltrating Lymphocytes Improves Neoantigen Prediction and Prioritization

Thi Mong Quynh Pham, Thành Nhân Nguyễn, Bui Que Tran Nguyen, Thi Tran, Nguyen My Diem Pham, Hoang Thien Phuc Nguyen, Thi Kim Cuong Ho, Dinh Viet Linh Nguyen, Huu Thinh Nguyen, Duc Huy Tran, Thanh Sang Tran, Truong-Vinh Ngoc Pham, Minh-Triet Le, Vy Nguyen, Minh‐Duy Phan, Hoa Giang, Hoai‐Nghia Nguyen, Le Son Tran   +17 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Identification of specific T-cell response and T-cell receptor targeting shared neoantigen for acute myeloid leukemia. [PDF]

Blood Cancer J
Zhou W, Yu J, Li F, Huang Y, Du J, Wu A, Wang K.   +6 more
europepmc   +1 more source