Results 301 to 310 of about 2,701,466 (355)
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2008
The T-cell antigen receptor complex (TCR/CD3) is a cell surface structure that defines the T lymphocyte lineage, where it fulfills two basic functions, namely antigen recognition and triggering of signals needed to mount adequate responses to foreign aggression and/or to undergo differentiation.
Jose M, Rojo +2 more
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The T-cell antigen receptor complex (TCR/CD3) is a cell surface structure that defines the T lymphocyte lineage, where it fulfills two basic functions, namely antigen recognition and triggering of signals needed to mount adequate responses to foreign aggression and/or to undergo differentiation.
Jose M, Rojo +2 more
openaire +3 more sources
Journal of Cell Science, 2001
Upon engagement of the TCR by antigen presented on major histocompatibility complex (MHC) molecules, the Src family kinase Lck is activated and proceeds to phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the e, δ, γ and ζ subunits of the TCR.
J, Lin, A, Weiss
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Upon engagement of the TCR by antigen presented on major histocompatibility complex (MHC) molecules, the Src family kinase Lck is activated and proceeds to phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the e, δ, γ and ζ subunits of the TCR.
J, Lin, A, Weiss
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Dermatologic Clinics, 1990
We have reviewed the knowledge of the human TCR and its implications in dermatology. The TCR has been shown to be the molecule responsible for specific cellular immunity in the same way that immunoglobulins confer humoral immunity. Much has been learned about the complex genomic organization of the TCR chains and how the great diversity of TCR proteins
K, Degitz, S W, Caughman
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We have reviewed the knowledge of the human TCR and its implications in dermatology. The TCR has been shown to be the molecule responsible for specific cellular immunity in the same way that immunoglobulins confer humoral immunity. Much has been learned about the complex genomic organization of the TCR chains and how the great diversity of TCR proteins
K, Degitz, S W, Caughman
openaire +2 more sources
Cytotherapy, 2003
Artificial T-cell receptors are generated by joining an Ag-recognizing domain (ectodomain) to the transmembrane and intracellular portion of a signaling molecule (endodomain). The ectodomain is most often derived from Ab variable chains, but may also be generated from T-cell receptor variable chains, as well as from other molecules. Various alternative
M, Pule, H, Finney, A, Lawson
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Artificial T-cell receptors are generated by joining an Ag-recognizing domain (ectodomain) to the transmembrane and intracellular portion of a signaling molecule (endodomain). The ectodomain is most often derived from Ab variable chains, but may also be generated from T-cell receptor variable chains, as well as from other molecules. Various alternative
M, Pule, H, Finney, A, Lawson
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T Cell Receptors and T Cell Development
1996Birds provide a valuable model system for the study of early development. Studies of immune system development and function in chickens have contributed to some of the central tenets in immunology. These include:(1) allorecognition by lymphocytes in graft-vs-host (GVH) reactions (Simonsen 1985), (2) clonal reactivity of immunocompetent lymphocytes ...
C H, Chen +6 more
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New England Journal of Medicine, 1985
During the past 25 years, we have gradually come to comprehend the underlying order of the complex family of lymphocytes.
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During the past 25 years, we have gradually come to comprehend the underlying order of the complex family of lymphocytes.
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Designer T cells by T cell receptor replacement
European Journal of Immunology, 2006AbstractT cell receptor (TCR) gene transfer is a convenient method to produce antigen‐specific T cells for adoptive therapy. However, the expression of two TCR in T cells could impair their function or cause unwanted effects by mixed TCR heterodimers. With five different TCR and four different T cells, either mouse or human, we show that some TCR are ...
Daniel, Sommermeyer +11 more
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T-Cell Receptor–Transduced T Cells
The Cancer Journal, 2015The large number of T-cell epitopes that have been found to be processed and presented on human tumors, now numbering in the hundreds, provides a rich source of targets for therapeutic interventions aimed at inducing durable tumor regression. Vaccination strategies aimed at inducing responses to these antigens have been largely ineffective, and it has ...
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2012
T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
Jennifer D, Stone +3 more
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T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
Jennifer D, Stone +3 more
openaire +2 more sources
1989
Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
P. Marrack +7 more
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Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
P. Marrack +7 more
openaire +1 more source