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2015
On B cells, specificity is mediated by surface immunoglobulin. On T cells, specificity is mediated by the T-cell receptor (TCR) for antigen. The first indications that T cells recognized antigen through a TCR were derived from functional assays using specific target-cell interactions.
Chris Mody, Howard Ceri
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On B cells, specificity is mediated by surface immunoglobulin. On T cells, specificity is mediated by the T-cell receptor (TCR) for antigen. The first indications that T cells recognized antigen through a TCR were derived from functional assays using specific target-cell interactions.
Chris Mody, Howard Ceri
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2008
The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
John G. Monroe, Randall J. Brezski
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The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
John G. Monroe, Randall J. Brezski
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Cytotherapy, 2003
Artificial T-cell receptors are generated by joining an Ag-recognizing domain (ectodomain) to the transmembrane and intracellular portion of a signaling molecule (endodomain). The ectodomain is most often derived from Ab variable chains, but may also be generated from T-cell receptor variable chains, as well as from other molecules. Various alternative
Alastair David Griffiths Lawson +2 more
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Artificial T-cell receptors are generated by joining an Ag-recognizing domain (ectodomain) to the transmembrane and intracellular portion of a signaling molecule (endodomain). The ectodomain is most often derived from Ab variable chains, but may also be generated from T-cell receptor variable chains, as well as from other molecules. Various alternative
Alastair David Griffiths Lawson +2 more
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Unplugging the T cell receptor [PDF]
Nature Immunology, 2003 Certain infectious diseases, autoimmune disorders and cancers are associated with T cell receptor ζ chain down-regulation. Interferon-γ production by T helper type 1 cells seems to be pivotal in this process.
POLI , GUIDO, BORDIGNON , CLAUDIO
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New England Journal of Medicine, 1977
Intercellular transfer of information is frequently accomplished through receptors that recognize specific chemical signals such as hormones or neurotransmitters and respond to their presence by in...
Steven Jacobs, Pedro Cuatrecasas
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Intercellular transfer of information is frequently accomplished through receptors that recognize specific chemical signals such as hormones or neurotransmitters and respond to their presence by in...
Steven Jacobs, Pedro Cuatrecasas
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Journal of Cell Science, 2001
Upon engagement of the TCR by antigen presented on major histocompatibility complex (MHC) molecules, the Src family kinase Lck is activated and proceeds to phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the e, δ, γ and ζ subunits of the TCR.
Arthur Weiss, Joseph Lin
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Upon engagement of the TCR by antigen presented on major histocompatibility complex (MHC) molecules, the Src family kinase Lck is activated and proceeds to phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the e, δ, γ and ζ subunits of the TCR.
Arthur Weiss, Joseph Lin
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Dermatologic Clinics, 2007
Langerhans cells (LC) are a subtype of dendritic cells, which reside in the epidermis. LCs are antigen-presenting cells that originate in bone marrow and enter the epidermis through blood vessels. LCs exhibit a variety of antigen receptors that are able to respond to a wide range of antigens.
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Langerhans cells (LC) are a subtype of dendritic cells, which reside in the epidermis. LCs are antigen-presenting cells that originate in bone marrow and enter the epidermis through blood vessels. LCs exhibit a variety of antigen receptors that are able to respond to a wide range of antigens.
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2012
T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
David M. Kranz +3 more
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T lymphocytes express on their surface a heterodimeric αβ receptor, called the T cell receptor (TCR), which recognizes foreign antigens. Unlike antibodies, the recognition requires both an antigenic peptide epitope and a protein encoded by the major histocompatibility complex (MHC).
David M. Kranz +3 more
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JAMA: The Journal of the American Medical Association, 1988
A VERTEBRATE is an attractive culture medium for viruses, bacteria, fungi, and metazoan parasites. It is therefore understandable that vertebrates have had to develop a body defense mechanism directed toward these pathogens for their emergence and survival. This defense mechanism is the See also pp 1834 and 1837. immune system.
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A VERTEBRATE is an attractive culture medium for viruses, bacteria, fungi, and metazoan parasites. It is therefore understandable that vertebrates have had to develop a body defense mechanism directed toward these pathogens for their emergence and survival. This defense mechanism is the See also pp 1834 and 1837. immune system.
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Cell receptors for paramyxoviruses
Archives of Virology, 1977Treatment of chick embryo fibroblasts, calf kidney and BHK cells for 30 minutes with the enzyme neuraminidase from Vibrio cholerae causes an enhancement of the per cent of attached NDV virions. This enhancement does not depend on the multiplicity of infection.
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