Cytotoxic T Lymphocytes and Vaccine Development [PDF]
Journal of Biomedicine and Biotechnology, 2010 Cytotoxic T-lymphocytes (CTL) are famous for their ability to kill tumor, allogeneic and virus-infected cells. However, an emerging literature has now demonstrated that CTL also possess the ability to directly recognize and kill bacteria, parasites, and ...
Klonowski, Kim +2 more
core +12 more sources
Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells [PDF]
Nature Communications, 2018 A critical determinant of tumor eradication by adoptive immunotherapy is the tumor associated antigen recognized by cytotoxic T lymphocytes. Here the authors generate ex vivo autologous cytotoxic T lymphocytes by exposure to antigens induced by DNA ...
Alexei F. Kirkin +16 more
doaj +4 more sources
Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema [PDF]
Respiratory Research, 2007 Background It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity.
Parent Julie +2 more
doaj +4 more sources
Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations [PDF]
Haematologica, 2013 Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies.
Maciej Machaczka +7 more
doaj +3 more sources
Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. [PDF]
PLoS ONE, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Chi Wang Ip +10 more
doaj +4 more sources
Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner. [PDF]
PLoS Pathogens, 2020 Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan +12 more
doaj +3 more sources
Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation [PDF]
Transplant InternationalXenotransplantation represents a potential solution to the shortage of organs for transplantation. The recent advancements in porcine genetic modification have addressed hyperacute and acute vascular rejection; however, challenges persist with regard to ...
Viktoriia Galdina +2 more
doaj +2 more sources
The metabolism of cells regulates their sensitivity to NK cells depending on p53 status [PDF]
Scientific Reports, 2022 Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymphocytes, which
Sana Belkahla +16 more
doaj +3 more sources
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells [PDF]
eLife, 2017 The differentiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune responses.
Alexandria C Wells +9 more
doaj +3 more sources
Autoimmune destruction of pericytes as the cause of diabetic retinopathy [PDF]
Clinical Ophthalmology, 2008 Duncan D AdamsFaculty of Medicine, University of Otago, Dunedin, New ZealandAbstract: In diabetic retinopathy, collapse of the retinal vasculature is associated with loss of the pericytes.
Duncan D Adams
doaj +3 more sources