Results 31 to 40 of about 724,385 (326)

In vitro Generation of Cytotoxic T Cells With Potential for Adoptive Tumor Immunotherapy of Multiple Myeloma

Frontiers in Immunology, 2019
Multiple myeloma is a life-threatening hematological malignancy, which is rarely curable by conventional therapies. Immunotherapy, using tumor antigen-specific, cytotoxic T-lymphocytes, may represent an alternative or additional treatment for multiple ...
Wafaa S. Khalaf, Wafaa S. Khalaf, Mamta Garg, Yehia S. Mohamed, Yehia S. Mohamed, Cordula M. Stover, Michael J. Browning, Michael J. Browning   +7 more
doaj   +1 more source

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

Journal of Experimental Medicine, 1998
Dendritic cells, but not macrophages, efficiently phagocytose apoptotic cells and cross-present viral, tumor, and self-antigens to CD8+ T cells. This in vitro pathway corresponds to the in vivo phenomena of cross-priming and cross-tolerance.
M. Albert, S. Pearce, Loise M. Francisco, B. Sauter, P. Roy, R. Silverstein, N. Bhardwaj   +6 more
semanticscholar   +1 more source

Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

Cell Death and Disease, 2017
Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells.
P. Bhat, G. Leggatt, N. Waterhouse, I. Frazer   +3 more
semanticscholar   +1 more source

HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]

, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula, Braga, Sofia, Cabral, M. Guadalupe, Jacinto, António, Saraiva, Diana P.   +4 more
core   +2 more sources

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma [PDF]

, 2000
Immune surveillance by cytotoxic lymphocytes against cancer has been postulated for decades, but direct evidence for the role of cytotoxic lymphocytes in protecting against spontaneous malignancy has been lacking.
Godfrey, DI, MacGregor, D, Smyth, MJ, Street, SEA, Thia, KYT, Trapani, JA   +5 more
core   +2 more sources

Transcriptional Reprogramming of Mature CD4+ T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes

Nature Immunology, 2013
TCRαβ thymocytes differentiate into either CD8αβ+ cytotoxic T lymphocytes or CD4+ helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic ...
D. Mucida, M. M. Husain, Sawako Muroi, Femke van Wijk, Ryo Shinnakasu, Y. Naoe, B. Reis, Yujun Huang, F. Lambolez, Michael Docherty, A. Attinger, J. Shui, Gisen Kim, C. Lena, S. Sakaguchi, Chizuko Miyamoto, Peng Wang, K. Atarashi, Yunji Park, T. Nakayama, K. Honda, W. Ellmeier, M. Kronenberg, I. Taniuchi, H. Cheroutre   +24 more
semanticscholar   +1 more source

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Cellular & Molecular Immunology, 2020
In December 2019, a novel coronavirus was first reported in Wuhan, China. It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is responsible for coronavirus disease 2019 (COVID-19).
M. Zheng, Yong Gao, Gang Wang, Guobin Song, Siyu Liu, Dandan Sun, Yuanhong Xu, Z. Tian   +7 more
semanticscholar   +1 more source

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.

PLoS Pathogens, 2020
Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan, Shuang Li, Jan Meeldijk, Bernadet Blijenberg, Astrid Hendriks, Karlijn J W M van Boxtel, Sara P H van den Berg, Ian J Groves, Martin Potts, Adriana Svrlanska, Thomas Stamminger, Mark R Wills, Niels Bovenschen   +12 more
doaj   +1 more source

Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives [PDF]

, 2003
While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant.
Biagi, Ettore, Bollard, Catherine, Brenner, Malcolm, Rousseau, Raphael   +3 more
core   +11 more sources

Cytotoxic T lymphocytes in regional lymph nodes in colon cancer

Acta Biomedica Scientifica
Background. The study of the subpopulation composition of cytotoxic T lymphocytes and the expression of co-inhibitory proteins on their surface in regional lymph nodes is necessary for the development of new methods of targeted therapy for colorectal ...
V. V. Kryukova, V. L. Tsepelev, P. P. Tereshkov   +2 more
doaj   +1 more source