Results 31 to 40 of about 564,677 (319)

THE ROLE OF SUBPOPULATIONS OF CD8+ T LYMPHOCYTES IN THE DEVELOPMENT OF PREGNANCY

open access: yesМедицинская иммунология, 2018
At the present time, a broad spectrum of CD8+ T lymphocyte subsets is revealed, including naïve cells, memory cells and regulatory subpopulations. Along with cells with high cytolytic activity, some subsets with marked regulatory activity were found ...
O. I. Stepanova   +5 more
doaj   +1 more source

Towards Understanding the Lymph Node Response to Skin Infection with Saprophytic Staphylococcus epidermidis

open access: yesBiomedicines, 2022
In individuals with lymphedema, diabetic foot, or other diseases, infections with saprophytes are common. The response of major cell subpopulations in the draining lymph nodes to skin infection with Staphylococcus epidermidis was assessed using the rat ...
Marta Cąkała-Jakimowicz   +1 more
doaj   +1 more source

Inferring HIV escape rates from multi-locus genotype data [PDF]

open access: yesFront. Immunol. 4:252. 2013, 2013
Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells. Virus variants whose protein fragments are not efficiently presented on infected cells or whose fragments are ...
arxiv   +1 more source

Cytotoxic CD8+ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2019
Significance CD8+ T lymphocytes, which are typically devoted to eliminate malignant and infected cells, have been described in the central nervous system (CNS) of patients and mice with amyotrophic lateral sclerosis (ALS).
Emmanuelle Coque   +20 more
semanticscholar   +1 more source

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

open access: yesМедицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova   +5 more
doaj   +1 more source

Selective miRNA inhibition in CD8+ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses

open access: yesFrontiers in Immunology, 2022
miRNAs dictate relevant virus-host interactions, offering new avenues for interventions to achieve an HIV remission. We aimed to enhance HIV-specific cytotoxic responses—a hallmark of natural HIV control— by miRNA modulation in T cells.
Nadia Madrid-Elena   +23 more
doaj   +1 more source

Immune networks: multi-tasking capabilities near saturation [PDF]

open access: yesJournal of Physics A 46, 415003 (2013). (IOP Select: Highlights-2013), 2013
Pattern-diluted associative networks were introduced recently as models for the immune system, with nodes representing T-lymphocytes and stored patterns representing signalling protocols between T- and B-lymphocytes. It was shown earlier that in the regime of extreme pattern dilution, a system with $N_T$ T-lymphocytes can manage a number $N_B!=!\order ...
arxiv   +1 more source

Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations

open access: yesHaematologica, 2013
Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies.
Maciej Machaczka   +7 more
doaj   +1 more source

Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema

open access: yesRespiratory Research, 2007
Background It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity.
Parent Julie   +2 more
doaj   +1 more source

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

open access: yesJournal of Experimental Medicine, 1998
Dendritic cells, but not macrophages, efficiently phagocytose apoptotic cells and cross-present viral, tumor, and self-antigens to CD8+ T cells. This in vitro pathway corresponds to the in vivo phenomena of cross-priming and cross-tolerance.
M. Albert   +6 more
semanticscholar   +1 more source

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