Results 201 to 210 of about 176,443 (228)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

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Reduced regulatory T lymphocytes in migraine patients

Neurological Research, 2021
Objectives: Migraine is a primary headache disorder with unknown pathophysiology. Recently, many studies have suggested the role of immune dysfunction in the pathophysiology of this disorder. In this study, we investigated the percentage of regulatory T cells (Treg cells) in different migraine categories.Methods: Peripheral blood samples of 40 newly ...
Fardin Faraji, Mana Shojapour, Iman Farahani, Ali Ganji, Ghasem Mosayebi   +4 more
openaire   +2 more sources

Regulatory T lymphocytes as a therapy for ischemic stroke

Seminars in Immunopathology, 2022
Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4+CD25+Foxp3+ regulatory T (Treg) cells play important immunosuppressive roles to curtail inflammatory responses and regain immune homeostasis after stroke.
Miao Wang, Angus W. Thomson, Fang Yu, Rimi Hazra, Aditi Junagade, Xiaoming Hu   +5 more
openaire   +2 more sources

Regulatory function of human CD4+ cytolytic T lymphocytes

Transplant Immunology, 1999
Allograft rejection is mediated by both CD4+ and CD8+ T cells. The lytic function of the classic CD8+ cytolytic T lymphocytes (CTL) occurs through recognition of allogeneic major histocompatibility complex (MHC) class I on the surface of the graft. CD4+ CTL recognize MHC class II through a direct recognition pathway or an indirect pathway where MHC ...
N J, Poindexter, M A, Smith, A E, Haynes, T, Mohanakumar   +3 more
openaire   +2 more sources

Murine CD8+ regulatory T lymphocytes: The new era

Human Immunology, 2008
Regulatory T lymphocytes unequivocally play a major role in the maintenance of immunologic homeostasis. The first descriptions of regulatory T lymphocytes concerned CD8(+) cells, but this field was brought into discredit when some of its central tenets turned out to be erroneous. CD4(+) regulatory T cells took over and, with the help of newly developed
Céline, Pomié, Ingrid, Ménager-Marcq, Joost P M, van Meerwijk   +2 more
openaire   +2 more sources

Regulatory T lymphocytes in traumatic brain injury

Neurochemistry International
Traumatic brain injury (TBI) presents a significant global health challenge with no effective therapies developed to date. Regulatory T lymphocytes (Tregs) have recently emerged as a potential therapy due to their critical roles in maintaining immune homeostasis, reducing inflammation, and promoting brain repair.
Jiajing Shan, Ruyu Shi, Rimi Hazra, Xiaoming Hu   +3 more
openaire   +2 more sources

Regulatory Role of T Lymphocytes in Atopic Dermatitis

2008
Eczema does not occur in the absence of T cells. Here we provide an overview on the regulatory impact which T cells have on the establishment and maintenance of atopic dermatitis. Particularly, we outline the role of different T-helper cell subsets (i.e.
T, Werfel, M, Wittmann
openaire   +2 more sources

Development of Thymic Regulatory T Lymphocytes

2019
A healthy immune system should maintain a balance between the ability to respond to infectious agents and tumor cells at the same time that sustains self-tolerance. For this purpose, the immune system must be capable of restraining foreign antigens, stopping the immune response after the resolution of a problem and blocking autoreactivity of immune ...
Larissa Vasconcelos-Fontes, Rafaella Ferreira-Reis, João Ramalho Ortigão-Farias, Arnon Dias Jurberg, Vinicius Cotta-de-Almeida   +4 more
openaire   +1 more source

Lag3+ regulatory T lymphocytes in critical carotid artery stenosis

Clinical and Experimental Medicine, 2019
The aim of this study was to evaluate CD25+ and Lag3+ T regulatory subpopulations in patients with critical carotid artery stenosis (CAS) and Stanford-A acute aortic dissection (AAD). CD25+ and Lag3+ were measured in 36 patients affected by CAS and 24 patients with Stanford type A AAD.
Del Porto F., Cifani N., Proietta M., Dezi T., Tritapepe L., Raffa S., Micaloni A., Taurino M.   +7 more
openaire   +3 more sources