Results 21 to 30 of about 269,589 (144)

REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2012
Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL).
Giovanni D’Arena, Giovanni Rossi, Barbara Vannata, Silvia Deaglio, Giovanna Mansueto, Fiorella D’Auria, Teodora Statuto, Vittorio Simeon, DE MARTINO, LAURA, Aurelio Marandino, Giovanni Del Poeta, DE FEO, Vincenzo, Pellegrino Musto   +12 more
openaire   +9 more sources

The Role of Cluster of Differentiation 39 (CD39) and Purinergic Signaling Pathway in Viral Infections

Pathogens, 2023
CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73 pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect.
Alaa Elsaghir, Ehsan M. W. El-Sabaa, Abdulrahman K. Ahmed, Sayed F. Abdelwahab, Ibrahim M. Sayed, Mohamed A. El-Mokhtar   +5 more
doaj   +1 more source

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

Neurobiology of Disease, 2012
Activated microglia and infiltrating lymphocytes are neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), a fatal motoneuron disease.
Weihua Zhao, David R. Beers, Bing Liao, Jenny S. Henkel, Stanley H. Appel   +4 more
doaj   +1 more source

Neutrophil-Regulatory Tn Lymphocytes [PDF]

Immunologic Research, 2006
The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells.
Ley, Klaus, Smith, Emily, Stark, Matthew
openaire   +3 more sources

FEATURES OF THE PHENOTYPE OF REGULATORY T CELLS IN EARLY AND ADVANCED RHEUMATOID ARTHRITIS

Научно-практическая ревматология, 2018
Objective: to analyze the levels of CD3+, CD3+CD4+, CD3+CD8+, and CD3-CD56+ T lymphocytes, FoxP3+ regulatory T cells (Treg), and CD19+ B lymphocytes in patients with early and advanced rheumatoid arthritis (RA). Subjects and methods.
A. S. Avdeeva, Yu. P. Rubtsov, T. V. Popkova, D. T. Dyikanov, A. P. Aleksankin, E. L. Nasonov   +5 more
doaj   +1 more source

Predictors of Immunosuppressive Regulatory T Lymphocytes in Healthy Women [PDF]

Journal of Cancer Epidemiology, 2012
Immunosuppressive regulatory T (Treg) cells play an important role in antitumor immunity, self-tolerance, transplantation tolerance, and attenuation of allergic response. Higher proportion of Treg cells has been observed in peripheral blood of cancer cases compared to controls.
Warren Davis, Kirsten B. Moysich, Kunle Odunsi, Shalaka S. Hampras, Nicholas Furlani, Paul K. Wallace, Mary Nesline   +6 more
openaire   +2 more sources

Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4

Frontiers in Immunology, 2021
Although the human immune response to cancer is naturally potent, it can be severely disrupted as a result of an immunosuppressive tumor microenvironment.
Tobias Burkard, Caroline Dreis, Martina Herrero San Juan, Meik Huhn, Andreas Weigert, Josef M. Pfeilschifter, Heinfried H. Radeke   +6 more
doaj   +1 more source

Prognostic significance of CD4-positive regulatory T cells in tumor draining lymph nodes from patients with bladder cancer

Heliyon, 2020
Introduction and methods: To clarify the role of CD4+ regulatory T cells in bladder cancer, we investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow ...
Ali Ariafar, Yasmin Vahidi, Maryam Fakhimi, Ardalan Asadollahpour, Nasrollah Erfani, Zahra Faghih   +5 more
doaj   +1 more source

A gene regulatory network armature for T lymphocyte specification [PDF]

Proceedings of the National Academy of Sciences, 2008
Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process, we have used high-resolution analysis of regulatory gene expression trajectories from
Georgescu, Constantin, Longabaugh, William J. R., Scripture-Adams, Dierdre D., David-Fung, Elizabeth-Sharon, Yui, Mary A., Zarnegar, Mark A., Bolouri, Hamid, Rothenberg, Ellen V.   +7 more
openaire   +5 more sources

Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia [PDF]

OncoImmunology, 2016
Chronic lymphocytic leukemia (CLL) is characterized by an abnormal expansion of mature B cells in the bone marrow and their accumulation in blood and secondary lymphoid organs. Tumor CLL cells share expression of various surface molecules with many subsets of B cells and have several common characteristics with regulatory B cells (B regs). However, the
Mohr, Audrey, Renaudineau, Yves, Bagacean, Cristina, Pers, Jacques-Olivier, Jamin, Christophe, Bordron, Anne   +5 more
openaire   +4 more sources