Results 31 to 40 of about 235,846 (125)

Formation of regulatory modules by local sequence duplication [PDF]

, 2011
Turnover of regulatory sequence and function is an important part of molecular evolution. But what are the modes of sequence evolution leading to rapid formation and loss of regulatory sites? Here, we show that a large fraction of neighboring transcription factor binding sites in the fly genome have formed from a common sequence origin by local ...
arxiv   +1 more source

Ação dos linfócitos T regulatórios em transplantes T regulatory lymphocytes action in transplants

Revista Brasileira de Hematologia e Hemoterapia, 2008
O sistema imunológico humano possui um significado comum de proteção contra antígenos estranhos com potencialidade patogênica ou não, ativando uma ação coletiva e coordenada entre células e moléculas. Embora sendo um sistema benéfico, deve ser controlado
Bruno A. Faria, Simone M. Silva, Maria Theresa C. L. Abreu, Marcelo H. Napimoga   +3 more
doaj   +1 more source

Investigating age-related dynamics and transcriptional signatures of CD8⁺HLA-DR⁺ regulatory T lymphocytes: perspectives in understanding immune system aging

Медицинская иммунология
The ability of the CD8+HLA-DR+ regulatory T lymphocytes population to regulate the immune response was first described several years ago. It is known that the suppressive effects of these cells depend on intercellular interactions and are mediated by the
K. S. Matveeva, S. A. Rybtsov, D. V. Shevyrev   +2 more
doaj   +1 more source

Loss of chromosome Y in regulatory T cells

BMC Genomics
Background Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer.
Jonas Mattisson, Jonatan Halvardson, Hanna Davies, Bożena Bruhn-Olszewska, Paweł Olszewski, Marcus Danielsson, Josefin Bjurling, Amanda Lindberg, Ammar Zaghlool, Edyta Rychlicka-Buniowska, Jan P. Dumanski, Lars A. Forsberg   +11 more
doaj   +1 more source

RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.

PLoS Biology, 2022
Within the immune system, microRNAs (miRNAs) exert key regulatory functions. However, what are the mRNA targets regulated by miRNAs and how miRNAs are transcriptionally regulated themselves remain for the most part unknown. We found that in primary human
Michele Chirichella, Niccolò Bianchi, Emina Džafo, Elena Foli, Francesco Gualdrini, Amy Kenyon, Gioacchino Natoli, Silvia Monticelli   +7 more
doaj   +1 more source

Regulatory Dynamics on Random Networks: Asymptotic Periodicity and Modularity [PDF]

, 2007
We study the dynamics of discrete-time regulatory networks on random digraphs. For this we define ensembles of deterministic orbits of random regulatory networks, and introduce some statistical indicators related to the long-term dynamics of the system.
arxiv   +1 more source

Clinical and prognostic significance of T-regulatory cells and CD28 expression on T-lymphocytes in patients with immune thrombocytopenia

Онкогематология
Background. The leading role in the control of the immune response and peripheral tolerance is played by T-regulatory cells, as well as costimulatory molecules C28 on T-lymphocytes, which are necessary for effective activation.
Yu. Yu. Chuksina, S. G. Zakharov, T. A. Mitina, A. N. Khmelevskaya   +3 more
doaj   +1 more source

Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival

EMBO Molecular Medicine, 2012
In amyotrophic lateral sclerosis (ALS) mice, regulatory T‐lymphocytes (Tregs) are neuroprotective, slowing disease progression. To address whether Tregs and FoxP3, a transcription factor required for Treg function, similarly influence progression rates ...
Jenny S. Henkel, David R. Beers, Shixiang Wen, Andreana L. Rivera, Karen M. Toennis, Joan E. Appel, Weihua Zhao, Dan H. Moore, Suzanne Z. Powell, Stanley H. Appel   +9 more
doaj   +1 more source

The changes of CD4+CD25+/CD4+ proportion in spleen of tumor-bearing BALB/c mice

Journal of Translational Medicine, 2005
CD4+CD25+ regulatory T lymphocytes (TR) constitute 5–10% of peripheral CD4+ T cells in naive mice and humans, and play an important role in controlling immune responses.
Peng Rui-Qing, Ding Ya, Zhang Xiao-Shi, Liu Ji-Yan, Cheng Xia, Zhang Nian-Hua, Xia Jian-Chuan, Zeng Yi-Xin   +7 more
doaj   +1 more source

Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis

Molecular Autism, 2021
Background Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients ...
Pierre Ellul, Michelle Rosenzwajg, Hugo Peyre, Gwladys Fourcade, Encarnita Mariotti-Ferrandiz, Vincent Trebossen, David Klatzmann, Richard Delorme   +7 more
doaj   +1 more source