Results 41 to 50 of about 451,182 (276)

The Cell-Cycle Regulatory Protein p21CIP1/WAF1 Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis. [PDF]

, 2020
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB.
Boesze-Battaglia, Kathleen, Shenker, Bruce J, Walker, Lisa M, Weiss, Robert H, Zekavat, Ali   +4 more
core   +2 more sources

A gene regulatory network armature for T lymphocyte specification [PDF]

Proceedings of the National Academy of Sciences, 2008
Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process, we have used high-resolution analysis of regulatory gene expression ...
Georgescu, Constantin, Longabaugh, William J. R., Scripture-Adams, Dierdre D., David-Fung, Elizabeth-Sharon, Yui, Mary A., Zarnegar, Mark A., Bolouri, Hamid, Rothenberg, Ellen V.   +7 more
openaire   +3 more sources

CD8+ T Lymphocytes: Crucial Players in Sjögren’s Syndrome

Frontiers in Immunology, 2021
Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands.
Huimin Zhou, Huimin Zhou, Jun Yang, Jie Tian, Shengjun Wang, Shengjun Wang   +5 more
doaj   +1 more source

Immune regulation in Chandipura virus infection: characterization of CD4+ T regulatory cells from infected mice

Virology Journal, 2011
Back ground Chandipura virus produces acute infection in mice. During infection drastic reduction of CD4+, CD8+ and CD19 + cell was noticed. Depletion of lymphocytes also noticed in spleen.
Shahir Prajakta, Anukumar Balakrishnan
doaj   +1 more source

Predictors of Immunosuppressive Regulatory T Lymphocytes in Healthy Women [PDF]

Journal of Cancer Epidemiology, 2012
Immunosuppressive regulatory T (Treg) cells play an important role in antitumor immunity, self-tolerance, transplantation tolerance, and attenuation of allergic response. Higher proportion of Treg cells has been observed in peripheral blood of cancer cases compared to controls.
Hampras, Shalaka S., Nesline, Mary, Wallace, Paul K., Odunsi, Kunle, Furlani, Nicholas, Davis, Warren, Moysich, Kirsten B.   +6 more
openaire   +2 more sources

Dynamic assessment of T-lymphocytes and humoral immunity in patients with acute coronary syndrome, with and without COVID-19, depending on the content of CD3⁺CD8⁺T-lymphocytes

Медицинский вестник Юга России
Objective: to evaluate the dynamics of the T- and B-cell immunity in patients with acute coronary syndrome (ACS) who have and have not had COVID-19, depending on the number of CD3+CD8+T-lymphocytes.Materials and methods: 65 men with ACS who underwent ...
E. A. Safronova, L. V. Ryabova, A. V. Zurochka, M. A. Dobrynina, E. V. Zadorina   +4 more
doaj   +1 more source

Cyclin kinase inhibitor p21: a mediator of immune tolerance: direct and indirect evidence [PDF]

, 2009
*Background:* Uncontrolled proliferation of T-cells is considered a barrier to the induction of transplantation tolerance by T regulatory cells. Therefore, cyclin kinase inhibitor p21, one of the most potent inhibitors of cell proliferation, may exert an
Ashwani Khanna
core   +1 more source

Tumor-Infiltrating γδ T Cells Suppress T and Dendritic Cell Function via Mechanisms Controlled by a Unique Toll-like Receptor Signaling Pathway [PDF]

, 2007
Summaryγδ T cells are important contributors to innate immunity against cancer, but their regulatory role in controlling immune responses remains largely unknown.
Guangyong Peng, Helen Y. Wang, Weiyi Peng, Yukiko Kiniwa, Kook Heon Seo, Rong-Fu Wang, Akira, Bauer, Boismenu, Brenner, Bukowski, Choudhary, Constant, Crellin, Curiel, Diefenbach, Dunn, Eberl, Girardi, Groh, Groh, Havran, Hayday, Hayday, Huang, Huang, Jameson, Jameson, Jurk, Kabelitz, Liu, Liyanage, Modlin, Okita, Pasare, Peng, Pennington, Pennington, Qin, Rosenberg, Sakaguchi, Sato, Sato, Shevach, Shin, Sutmuller, Sutmuller, Wan, Wang, Wang, Wang, Wang, Wang, Woo   +53 more
core   +6 more sources

CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation

Seminars in Immunology, 2006
Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens.
Joffre, Olivier, van Meerwijk, Joost
openaire   +3 more sources

The Influence of the Regulatory T Lymphocytes on Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Atherosclerosis is complex inflammatory disease of the arterial wall, in which T lymphocytes play a significant role.1 Since the recognition that T lymphocytes are present in human atherosclerotic plaque nearly 2 decades ago,2 research has focused on the functional importance of these cells in the atherosclerotic process.
Israel, Gotsman, Rajat, Gupta, Andrew H, Lichtman   +2 more
openaire   +2 more sources