Results 61 to 70 of about 449,121 (298)

Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis

Molecular Autism, 2021
Background Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients ...
Pierre Ellul, Michelle Rosenzwajg, Hugo Peyre, Gwladys Fourcade, Encarnita Mariotti-Ferrandiz, Vincent Trebossen, David Klatzmann, Richard Delorme   +7 more
doaj   +1 more source

To respond or not to respond - a personal perspective of intestinal tolerance [PDF]

, 2018
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka, A Goubier, A Iwasaki, A Konrad, A Limmer, A Mortha, A Vaillant, AJ MacPherson, Allan McI. Mowat, AM Mowat, B Cassani, B Dubois, B Jabri, B Johansson-Lindbom, C Asseman, C Berlin, C Siewert, C Varol, CC Bain, CC Bain, CL Scott, CL Scott, CM Sun, CR Mackay, CR Stokes, D Esterhazy, D Fina, D Mucida, D Sichien, DP McGovern, DS Shouval, E Jaensson, E Jaensson-Gyllenback, E Mazzini, E Zigmond, EJ Kunkel, EM Nilsen, EM Nilsen, F Broere, F Ginhoux, F Hauet-Broere, F Powrie, FG Chirdo, G Lack, G Matteoli, G Mayrhofer, G Monteleone, GG MacPherson, H Arentz-Hanson, H Fukaura, H Tlaskalova, HG Wells, HL Klaasen, HL Weiner, HL Weiner, I Vicente-Suarez, ID Iliev, II Ivanov, J Farache, J Farache, JA Mattingly, JA Mattingly, JB Sun, JF Heremans, JH Niess, JL Coombes, JL Gowans, JL Viney, JM Blander, JP Hugot, JR Battisto, JR McDole, K Atarashi, K Atarashi, K Lahl, K Nagatani, K Takeda, KG McDonald, KM Luda, KM Smith, KP Zimmer, KS Kim, L Maiuri, L Maiuri, L Saurer, LA Hanson, LA Reynolds, LA Waaij van der, LM Sollid, M Boucard-Jourdin, M Butler, M Chieppa, M Karlsson, M Murai, M Rescigno, M Rimoldi, M Tsuji, M Yoshida, MH Jang, MH Jang, MO Li, MR Hepworth, MR Karlsson, MW Chase, N Korneychuk, N Satoh-Takayama, N Sudo, O Schulz, P Brandtzaeg, P Morrissey, PA Crabbe, PB Carter, PM Smith, R Bouziat, R Kuhn, R Zeng, R Zeng, RE Araya, RL Owen, RW DePaolo, S Hue, S Husby, S Husby, S Kawamoto, S Strobel, S Strobel, S Veenbergen, S Wilks, SI Hammerschmidt, SK Mazmanian, SV Kim, T Joeris, T Worbs, TB Tomasi Jr, TL Denning, U Hadis, V Cerovic, V Gaboriau-Routhiau, Y Chen, Y Cong, Y Ogura, ZM Falchuk, Ø Molberg   +142 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Self Model and the Conception of Biological Identity in Immunology [PDF]

, 2005
The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal ...
A.A. Freitas, A.I. Tauber, A.I. Tauber, A.I. Tauber, A.M. Silverstein, A.M. Silverstein, C.A. Buscaglia, D. Haig, D. Pardoll, D. Wiggins, D. Wilson, D.C. Douek, D.W. Bianchi, E. Seung, E.D. Carosella, Edgardo D. Carosella, F. Claas, F. Marincola, F.M. Burnet, F.M. Burnet, F.M. Burnet, F.M. Burnet, F.M. Burnet, F.M. Burnet, F.M. Burnet, F.M. Burnet, G. Boniolo, G.W. Leibniz, H. Atlan, H.G. Wells, H.H. Smits, I.R. Cohen, I.R. Cohen, J. Klein, J. Savill, J.B. Murphy, J.F.A.P. Miller, J.W. Kappler, K.C. Garcia, L. Margulis, L.S.K. Walker, L.V. Hooper, M.L. Albert, N. Girones, N. Lila, N. Nanda, N.K. Jerne, P. Ehrlich, P. Godfrey-Smith, P. Matzinger, P.G. Ashton-Rickardt, R. Lewontin, R. Medzhitov, R. Medzhitov, R. Owen, R. Pedotti, R.D. Berg, R.E. Billingham, R.E. Langman, R.M. Zinkernagel, S. Oyama, S. Sakaguchi, S.F. Gilbert, T. Pradeu, T.A. Ferguson, Thomas Pradeu, V.R. Aluvihare, W. Martin, Y. Belkaid, Y. Belkaid   +69 more
core   +3 more sources

Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial. [PDF]

, 2020
BACKGROUND:Zinc deficiency impairs immune function and is common among children in South-East Asia. OBJECTIVES:The effect of zinc supplementation on immune function in young Laotian children was investigated.
Andreini, Anzilotti, Barffour, Beck, Black, Boulay, Brown, Butt, Castillo-Duran, Charles B Stephensen, Chidchamai Kewcharoenwong, Gammoh, Ganjana Lertmemongkolchai, Gertrud U Schuster, Gibson, Guy-Marino Hinnouho, Haase, Hojyo, Honscheid, International Zinc Nutrition Consultative Group, International Zinc Nutrition Consultative Group, Inthira Tussakhon, Janet M Peerson, Jia, K Ryan Wessells, Kenneth H Brown, King, Lu, Maizels, Maxwell A Barffour, Mayo-Wilson, Maywald, Mehta, Prasad, Rajamanickam, Raqib, Ravin, Richter, Rosenkranz, Rosenkranz, Sandstead, Sazawal, Sengchanh Kounnavong, Sheikh, Shi, Sonja Y Hess, Tahan, Tepaamorndech, Walker, Wan, Waraporn Samer, Wessells, Wessells, WHO, Wu   +54 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Ação dos linfócitos T regulatórios em transplantes T regulatory lymphocytes action in transplants

Revista Brasileira de Hematologia e Hemoterapia, 2008
O sistema imunológico humano possui um significado comum de proteção contra antígenos estranhos com potencialidade patogênica ou não, ativando uma ação coletiva e coordenada entre células e moléculas. Embora sendo um sistema benéfico, deve ser controlado
Bruno A. Faria, Simone M. Silva, Maria Theresa C. L. Abreu, Marcelo H. Napimoga   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Regulatory T cells in children with recently diagnosed type 1 diabetes

Indian Journal of Endocrinology and Metabolism, 2012
Background: Regulatory T cells have an important role in the control of immune reactivity against self antigens and probably play a role in pathogenesis of type 1 diabetes (T1D).
Asmaa Mohamed Zahran, Khalid Ibrahem Elsayh, Kotb Abbass Metwalley   +2 more
doaj   +1 more source

RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.

PLoS Biology, 2022
Within the immune system, microRNAs (miRNAs) exert key regulatory functions. However, what are the mRNA targets regulated by miRNAs and how miRNAs are transcriptionally regulated themselves remain for the most part unknown. We found that in primary human
Michele Chirichella, Niccolò Bianchi, Emina Džafo, Elena Foli, Francesco Gualdrini, Amy Kenyon, Gioacchino Natoli, Silvia Monticelli   +7 more
doaj   +1 more source