Results 91 to 100 of about 13,171,622 (345)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]

, 2018
The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel, Leal Noval, Manuel, Ruiz-Mateos Carmona, Ezequiel, Tarancon Diez, Laura   +3 more
core   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Inflammatory and immune variables as predictors of survival in dogs with myxomatous mitral valve disease

BMC Veterinary Research
Background We aimed to investigate the association between selected inflammatory and immune variables and survival of dogs with myxomatous mitral valve disease (MMVD).
Martina Cimerman, Natalia Druzhaeva, Alenka Nemec Svete, Melita Hajdinjak, Katka Pohar, Alojz Ihan, Aleksandra Domanjko Petrič   +6 more
doaj   +1 more source

The issues of assessing reference ranges for the main subpopulations of blood lymphocytes in children at different ages

Медицинская иммунология
The age-related dynamics of main subsets of blood lymphocytes in children has been studied quite well, but the issue of the limits of reference values, especially at an early age, remains actual and important. The paper analyzes results of a direct study
E. L. Semikina, A. P. Toptygina, E. A. Kopyltsova, S. V. Petrichuk, S. S. Akulova, O. V. Kurbatova, A. V. Nozdracheva   +6 more
doaj   +1 more source

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.

Cell Stem Cell, 2018
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the adaptive immune system in PD.
Annika Sommer, F. Marxreiter, F. Krach, Tanja Fadler, Janina Grosch, Michele Maroni, Daniela Graef, E. Eberhardt, M. Riemenschneider, Gene W. Yeo, Z. Kohl, W. Xiang, F. Gage, J. Winkler, Iryna Prots, B. Winner   +15 more
semanticscholar   +1 more source

Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes [PDF]

, 2009
Background Congaplex® and Immuplex® are dietary supplements that have been traditionally used to support immune system function. The purpose of these experiments was to determine whether Congaplex® and Immuplex® affect immune function using primary and ...
Paul R Hanlon, Melissa G Robbins, Chris Scholl, David M Barnes, P Scott, HK Ziegler, RK Katial, L Borish, A Bose, E Gigi, BJ Moynihan, H Barth, A Corthay, WP Zeng, L Guo, J Pene, G Bouma, F Chamian, GS Firestein, S Kaminogawa, PS Haddad, S Clement-Kruzelweka, HY Shin, HJ Jeong, S Matsuba, Y Xi Bao, C Wang, YN Zhang, Y-K Yim, U Lindequist, P Alvarez, BT Metzger, NL Nisly, RS Schulof, TB Schwartz, BH Garcia, MW Pfaffl, SY Lyu, QT Gao, P Morazzoni, H Lu, P Devan, TP Tsao, P Anderson, J Nakagawa, S Hao, JS Lee, SL Chang, I Lampronti, M Kawamura   +49 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Impacts of tacrolimus and glucocorticoids on peripheral blood T and B lymphocyte subsets in myasthenia gravis

Frontiers in Immunology
BackgroundThis study aimed to investigate the impact of tacrolimus on peripheral T and B lymphocyte subsets in myasthenia gravis (MG) patients compared to glucocorticoid treatment.MethodsThis study retrospectively included MG patients at the First ...
Xuan Wu, Xuan Wu, Wei Chen, Wei Chen, Huanhuan Song, Guorong Xu, Guorong Xu   +6 more
doaj   +1 more source